LOCUS NP_872607 176 aa linear PRI 22-OCT-2008
DEFINITION ubiquitin-conjugating enzyme E2E 1 isoform 2 [Homo sapiens].
ACCESSION NP_872607
VERSION NP_872607.1 GI:33359691
DBSOURCE REFSEQ: accession NM_182666.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 176)
AUTHORS Lee,S., Hong,S. and Kang,S.
TITLE The ubiquitin-conjugating enzyme UbcH6 regulates the
transcriptional repression activity of the SCA1 gene product
ataxin-1
JOURNAL Biochem. Biophys. Res. Commun. 372 (4), 735-740 (2008)
PUBMED 18519031
REMARK GeneRIF: UbcH6 modulates the transcriptional repression activity of
ataxin-1 by modulating the degradation of ataxin-1.
REFERENCE 2 (residues 1 to 176)
AUTHORS Hong,S., Lee,S., Cho,S.G. and Kang,S.
TITLE UbcH6 interacts with and ubiquitinates the SCA1 gene product
ataxin-1
JOURNAL Biochem. Biophys. Res. Commun. 371 (2), 256-260 (2008)
PUBMED 18439907
REMARK GeneRIF: UbcH6 and ataxin-1 are E2-substrate cognate pairs in the
ubiquitin-proteasome system.
REFERENCE 3 (residues 1 to 176)
AUTHORS Takeuchi,T., Iwahara,S., Saeki,Y., Sasajima,H. and Yokosawa,H.
TITLE Link between the Ubiquitin Conjugation System and the ISG15
Conjugation System: ISG15 Conjugation to the UbcH6 Ubiquitin E2
Enzyme
JOURNAL J. Biochem. 138 (6), 711-719 (2005)
PUBMED 16428300
REFERENCE 4 (residues 1 to 176)
AUTHORS Listovsky,T., Oren,Y.S., Yudkovsky,Y., Mahbubani,H.M., Weiss,A.M.,
Lebendiker,M. and Brandeis,M.
TITLE Mammalian Cdh1/Fzr mediates its own degradation
JOURNAL EMBO J. 23 (7), 1619-1626 (2004)
PUBMED 15029244
REFERENCE 5 (residues 1 to 176)
AUTHORS Lehner,B., Semple,J.I., Brown,S.E., Counsell,D., Campbell,R.D. and
Sanderson,C.M.
TITLE Analysis of a high-throughput yeast two-hybrid system and its use
to predict the function of intracellular proteins encoded within
the human MHC class III region
JOURNAL Genomics 83 (1), 153-167 (2004)
PUBMED 14667819
REFERENCE 6 (residues 1 to 176)
AUTHORS Kramer,E.R., Scheuringer,N., Podtelejnikov,A.V., Mann,M. and
Peters,J.M.
TITLE Mitotic regulation of the APC activator proteins CDC20 and CDH1
JOURNAL Mol. Biol. Cell 11 (5), 1555-1569 (2000)
PUBMED 10793135
REFERENCE 7 (residues 1 to 176)
AUTHORS Lukas,C., Sorensen,C.S., Kramer,E., Santoni-Rugiu,E., Lindeneg,C.,
Peters,J.M., Bartek,J. and Lukas,J.
TITLE Accumulation of cyclin B1 requires E2F and cyclin-A-dependent
rearrangement of the anaphase-promoting complex
JOURNAL Nature 401 (6755), 815-818 (1999)
PUBMED 10548110
REFERENCE 8 (residues 1 to 176)
AUTHORS Anan,T., Nagata,Y., Koga,H., Honda,Y., Yabuki,N., Miyamoto,C.,
Kuwano,A., Matsuda,I., Endo,F., Saya,H. and Nakao,M.
TITLE Human ubiquitin-protein ligase Nedd4: expression, subcellular
localization and selective interaction with ubiquitin-conjugating
enzymes
JOURNAL Genes Cells 3 (11), 751-763 (1998)
PUBMED 9990509
REFERENCE 9 (residues 1 to 176)
AUTHORS Nuber,U., Schwarz,S., Kaiser,P., Schneider,R. and Scheffner,M.
TITLE Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7
(E2-F1) and characterization of their interaction with E6-AP and
RSP5
JOURNAL J. Biol. Chem. 271 (5), 2795-2800 (1996)
PUBMED 8576257
REFERENCE 10 (residues 1 to 176)
AUTHORS Chen,P., Johnson,P., Sommer,T., Jentsch,S. and Hochstrasser,M.
TITLE Multiple ubiquitin-conjugating enzymes participate in the in vivo
degradation of the yeast MAT alpha 2 repressor
JOURNAL Cell 74 (2), 357-369 (1993)
PUBMED 8393731
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC009139.1, BF698653.1 and
BI223271.1.
Summary: The modification of proteins with ubiquitin is an
important cellular mechanism for targeting abnormal or short-lived
proteins for degradation. Ubiquitination involves at least three
classes of enzymes: ubiquitin-activating enzymes, or E1s,
ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein
ligases, or E3s. This gene encodes a member of the E2
ubiquitin-conjugating enzyme family. Two alternatively spliced
transcript variants encoding distinct isoforms have been found for
this gene. [provided by RefSeq].
Transcript Variant: This variant (2) lacks an in-frame exon and
thus encodes a shorter isoform (2), as compared to variant 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..176
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="3"
/map="3p24.2"
Protein 1..176
/product="ubiquitin-conjugating enzyme E2E 1 isoform 2"
/EC_number="6.3.2.19"
/note="ubiquitin-conjugating enzyme E2E 1 (homologous to
yeast UBC4/5); ubiquitin-protein ligase E1; ubiquitin
carrier protein E1"
/calculated_mol_wt=19368
CDS 1..176
/gene="UBE2E1"
/gene_synonym="UBCH6"
/coded_by="NM_182666.1:175..705"
/note="isoform 2 is encoded by transcript variant 2"
/db_xref="CCDS:CCDS2639.1"
/db_xref="GeneID:7324"
/db_xref="HGNC:12477"
/db_xref="MIM:602916"
ORIGIN
1 msdddsrast ssssssssnq qteketntpk kkeskvsmsk nskllstsak sagpkgdniy
61 ewrstilgpp gsvyeggvff lditftpeyp fkppkvtfrt riyhcninsq gvicldilkd
121 nwspaltisk vllsicsllt dcnpadplvg siatqymtnr aehdrmarqw tkryat
//