LOCUS NP_857634 170 aa linear PRI 23-NOV-2008
DEFINITION peroxiredoxin 5 isoform b precursor [Homo sapiens].
ACCESSION NP_857634
VERSION NP_857634.1 GI:32455260
DBSOURCE REFSEQ: accession NM_181651.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 170)
AUTHORS Starr,J.M., Shiels,P.G., Harris,S.E., Pattie,A., Pearce,M.S.,
Relton,C.L. and Deary,I.J.
TITLE Oxidative stress, telomere length and biomarkers of physical aging
in a cohort aged 79 years from the 1932 Scottish Mental Survey
JOURNAL Mech. Ageing Dev. (2008) In press
PUBMED 18977241
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
Publication Status: Available-Online prior to print
REFERENCE 2 (residues 1 to 170)
AUTHORS Smeets,A., Marchand,C., Linard,D., Knoops,B. and Declercq,J.P.
TITLE The crystal structures of oxidized forms of human peroxiredoxin 5
with an intramolecular disulfide bond confirm the proposed
enzymatic mechanism for atypical 2-Cys peroxiredoxins
JOURNAL Arch. Biochem. Biophys. 477 (1), 98-104 (2008)
PUBMED 18489898
REMARK GeneRIF: report here three crystal forms in which this
intramolecular disulfide bond is indeed observed. The structures
are characterized by the expected local unfolding of the
peroxidatic loop, but also by the unfolding of the resolving loop
REFERENCE 3 (residues 1 to 170)
AUTHORS Jurkunas,U.V., Rawe,I., Bitar,M.S., Zhu,C., Harris,D.L., Colby,K.
and Joyce,N.C.
TITLE Decreased expression of peroxiredoxins in Fuchs' endothelial
dystrophy
JOURNAL Invest. Ophthalmol. Vis. Sci. 49 (7), 2956-2963 (2008)
PUBMED 18378575
REMARK GeneRIF: Significantly decreased expression of Prx-2, -3, and -5 in
FED may suggest an alteration in the ability of endothelial cells
to withstand oxidant-induced damage and may be closely related to
the pathogenesis of this disease.
REFERENCE 4 (residues 1 to 170)
AUTHORS De Simoni,S., Goemaere,J. and Knoops,B.
TITLE Silencing of peroxiredoxin 3 and peroxiredoxin 5 reveals the role
of mitochondrial peroxiredoxins in the protection of human
neuroblastoma SH-SY5Y cells toward MPP+
JOURNAL Neurosci. Lett. 433 (3), 219-224 (2008)
PUBMED 18262354
REMARK GeneRIF: Our results show that mitochondrial PRDX-depleted cells
are more prone to oxidative damages and apoptosis induced by
MPP(+), a complex I inhibitor which provides an experimental
paradigm of Parkinson's disease.
REFERENCE 5 (residues 1 to 170)
AUTHORS Avila,P.C., Kropotov,A.V., Krutilina,R., Krasnodembskay,A.,
Tomilin,N.V. and Serikov,V.B.
TITLE Peroxiredoxin V contributes to antioxidant defense of lung
epithelial cells
JOURNAL Lung 186 (2), 103-114 (2008)
PUBMED 18219526
REMARK GeneRIF: Peroxiredoxin V (PRXV) is an important antioxidant protein
of lung epithelial cells. Its expression in the human lung
increases in inflammation.
REFERENCE 6 (residues 1 to 170)
AUTHORS Knoops,B., Clippe,A., Bogard,C., Arsalane,K., Wattiez,R.,
Hermans,C., Duconseille,E., Falmagne,P. and Bernard,A.
TITLE Cloning and characterization of AOEB166, a novel mammalian
antioxidant enzyme of the peroxiredoxin family
JOURNAL J. Biol. Chem. 274 (43), 30451-30458 (1999)
PUBMED 10521424
REFERENCE 7 (residues 1 to 170)
AUTHORS Yamashita,H., Avraham,S., Jiang,S., London,R., Van Veldhoven,P.P.,
Subramani,S., Rogers,R.A. and Avraham,H.
TITLE Characterization of human and murine PMP20 peroxisomal proteins
that exhibit antioxidant activity in vitro
JOURNAL J. Biol. Chem. 274 (42), 29897-29904 (1999)
PUBMED 10514471
REFERENCE 8 (residues 1 to 170)
AUTHORS Wattiez,R., Hermans,C., Bernard,A., Lesur,O. and Falmagne,P.
TITLE Human bronchoalveolar lavage fluid: two-dimensional gel
electrophoresis, amino acid microsequencing and identification of
major proteins
JOURNAL Electrophoresis 20 (7), 1634-1645 (1999)
PUBMED 10424490
REFERENCE 9 (residues 1 to 170)
AUTHORS Kropotov,A., Sedova,V., Ivanov,V., Sazeeva,N., Tomilin,A.,
Krutilina,R., Oei,S.L., Griesenbeck,J., Buchlow,G. and Tomilin,N.
TITLE A novel human DNA-binding protein with sequence similarity to a
subfamily of redox proteins which is able to repress
RNA-polymerase-III-driven transcription of the Alu-family
retroposons in vitro
JOURNAL Eur. J. Biochem. 260 (2), 336-346 (1999)
PUBMED 10095767
REFERENCE 10 (residues 1 to 170)
AUTHORS Hochstrasser,D.F., Frutiger,S., Paquet,N., Bairoch,A., Ravier,F.,
Pasquali,C., Sanchez,J.C., Tissot,J.D., Bjellqvist,B., Vargas,R. et
al.
TITLE Human liver protein map: a reference database established by
microsequencing and gel comparison
JOURNAL Electrophoresis 13 (12), 992-1001 (1992)
PUBMED 1286669
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AF242525.1 and BU598032.1.
Summary: This gene encodes a member of the peroxiredoxin family of
antioxidant enzymes, which reduce hydrogen peroxide and alkyl
hydroperoxides. The encoded protein may play an antioxidant
protective role in different tissues under normal conditions and
during inflammatory processes. This protein interacts with
peroxisome receptor 1. The crystal structure of this protein in its
reduced form has been resolved to 1.5 angstrom resolution. This
gene uses alternate in-frame translation initiation sites to
generate mitochondrial or peroxisomal/cytoplasmic forms. Three
transcript variants encoding distinct isoforms have been identified
for this gene. [provided by RefSeq].
Transcript Variant: This variant (2) lacks a segment in the coding
region, which leads to a frameshift, compared to variant 1. The
resulting isoform (b) contains a shorter and distinct C-terminus
compared to isoform a.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..170
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q13"
Protein 1..170
/product="peroxiredoxin 5 isoform b precursor"
/EC_number="1.11.1.15"
/note="antioxidant enzyme B166; thioredoxin peroxidase
PMP20; peroxisomal antioxidant enzyme; TPx type VI; liver
tissue 2D-page spot 71B; Alu co-repressor 1"
/calculated_mol_wt=17263
Region 1..170
/region_name="alternative start site"
/note="cytoplasmic/peroxisomal protein"
CDS 1..170
/gene="PRDX5"
/gene_synonym="PLP"
/gene_synonym="ACR1"
/gene_synonym="B166"
/gene_synonym="PRXV"
/gene_synonym="PMP20"
/gene_synonym="PRDX6"
/gene_synonym="SBBI10"
/gene_synonym="AOEB166"
/gene_synonym="MGC117264"
/gene_synonym="MGC142283"
/gene_synonym="MGC142285"
/coded_by="NM_181651.1:120..632"
/note="isoform b precursor is encoded by transcript
variant 2"
/db_xref="CCDS:CCDS8070.1"
/db_xref="GeneID:25824"
/db_xref="HGNC:9355"
/db_xref="MIM:606583"
ORIGIN
1 mglagvcalr rsagyilvgg aggqsaaaaa rrcsegewas ggvrsfsraa aamapikvgd
61 aipavevfeg epgnkvnlae lfkgkkgvlf gvpgaftpgc skvrlladpt gafgketdll
121 lddslvsifg nrrlkrfsmv vqdgivkaln vepdgtgltc slapniisql
//