LOCUS       NP_854431                294 aa            linear   BCT 21-JUL-2008
DEFINITION  3-hydroxyisobutyrate dehydrogenase MmsB [Mycobacterium bovis
            AF2122/97].
ACCESSION   NP_854431
VERSION     NP_854431.1  GI:31791938
DBSOURCE    REFSEQ: accession NC_002945.3
KEYWORDS    complete genome.
SOURCE      Mycobacterium bovis AF2122/97
  ORGANISM  Mycobacterium bovis AF2122/97
            Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
            Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium
            tuberculosis complex.
REFERENCE   1  (residues 1 to 294)
  AUTHORS   Garnier,T., Eiglmeier,K., Camus,J.C., Medina,N., Mansoor,H.,
            Pryor,M., Duthoy,S., Grondin,S., Lacroix,C., Monsempe,C., Simon,S.,
            Harris,B., Atkin,R., Doggett,J., Mayes,R., Keating,L.,
            Wheeler,P.R., Parkhill,J., Barrell,B.G., Cole,S.T., Gordon,S.V. and
            Hewinson,R.G.
  TITLE     The complete genome sequence of Mycobacterium bovis
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 100 (13), 7877-7882 (2003)
   PUBMED   12788972
REFERENCE   2  (residues 1 to 294)
  AUTHORS   Garnier,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAR-2003) Unite de Genetique Moleculaire Bacterienne
            Institut Pasteur, 28 rue du Docteur Roux, Paris Cedex 15 75724,
            France
  REMARK    TB Research Group, Veterinary Laboratories, Agency Weybridge,
            Woodham Lane, New Haw,Addlestone,   Surrey KT15 3NB, UK, Sanger
            Centre, Wellcome Trust Genome Campus, Hinxton,Cambridge CB10 1SA,
            UK, Genopole, Institut Pasteur, 28 Rue du Docteur Roux, 75724 Paris
            Cedex 15, France.
REFERENCE   3  (residues 1 to 294)
  CONSRTM   NCBI Microbial Genomes Annotation Project
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAR-2003) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   4  (residues 1 to 294)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (08-APR-2002) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CAD93635.
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..294
                     /organism="Mycobacterium bovis AF2122/97"
                     /strain="AF2122/97"
                     /db_xref="taxon:233413"
     Protein         1..294
                     /product="3-hydroxyisobutyrate dehydrogenase MmsB"
                     /EC_number="1.1.1.31"
                     /calculated_mol_wt=29548
     CDS             1..294
                     /gene="mmsB"
                     /locus_tag="Mb0773c"
                     /coded_by="complement(NC_002945.3:844537..845421)"
                     /note="Mb0773c, mmsB, len: 294 aa. Equivalent to Rv0751c,
                     len: 294 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 294 aa overlap). Probable mmsB,
                     3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31), highly
                     similar to others e.g. NP_102847.1|NC_002678
                     3-hydroxyisobutyrate dehydrogenase from Mesorhizobium loti
                     (294 aa); NP_420167.1|NC_002696 3-hydroxyisobutyrate
                     dehydrogenase from Caulobacter crescentus (298 aa); A32867
                     3-hydroxyisobutyrate dehydrogenase from Rattus norvegicus
                     (346 aa); etc. Also similar to methylmalonate semialdehyde
                     dehydrogenases e.g. M84911|PSE MMSRAB_3 methylmalonate
                     semialdehyde dehydrogenase from Pseudomonas aeruginosa
                     (298 aa), FASTA scores: opt: 786, E(): 0, (45.8% identity
                     in 297 aa overlap). Also similar to 6-phosphogluconate
                     dehydrogenases from Mycobacterium tuberculosis e.g. Rv1122
                     and Rv1844c. Contains PS00895 3-hydroxyisobutyrate
                     dehydrogenase signature. BELONGS TO THE
                     3-HYDROXYISOBUTYRATE DEHYDROGENASE FAMILY."
                     /transl_table=11
                     /db_xref="GeneID:1092416"
ORIGIN      
        1 mttiaflglg nmgapmsanl vgaghvvrgf dpaptaasga aahgvavfrs apeavaeadv
       61 vitmlptgev vrrcytdvla aarpatlfid sstisvtdar evhalaeshg mlqldapvsg
      121 gvkgaaaatl afmvggdest lrrarpvlep magkiihcga agagqaakvc nnmvlavqqi
      181 aiaeafvlae klglsaqslf dvitgatgnc wavhtncpvp gpvptspann dfkpgfstal
      241 mnkdlglamd avaatgatap lgshaadiya kfaadhadld fsavihtlra rada
//