LOCUS       NP_777195                197 aa            linear   MAM 22-OCT-2008
DEFINITION  glutathione peroxidase 4 [Bos taurus].
ACCESSION   NP_777195
VERSION     NP_777195.1  GI:27807491
DBSOURCE    REFSEQ: accession NM_174770.3
KEYWORDS    .
SOURCE      Bos taurus (cattle)
  ORGANISM  Bos taurus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
            Pecora; Bovidae; Bovinae; Bos.
REFERENCE   1  (residues 1 to 197)
  AUTHORS   Lapointe,J., Kimmins,S., Maclaren,L.A. and Bilodeau,J.F.
  TITLE     Estrogen selectively up-regulates the phospholipid hydroperoxide
            glutathione peroxidase in the oviducts
  JOURNAL   Endocrinology 146 (6), 2583-2592 (2005)
   PUBMED   15746255
  REMARK    GeneRIF: GPx-4 has an important role in the physiological control
            of peroxide tone in the bordering cells of the oviductal lumen
REFERENCE   2  (residues 1 to 197)
  AUTHORS   Ishiwata,H., Katsuma,S., Kizaki,K., Patel,O.V., Nakano,H.,
            Takahashi,T., Imai,K., Hirasawa,A., Shiojima,S., Ikawa,H.,
            Suzuki,Y., Tsujimoto,G., Izaike,Y., Todoroki,J. and Hashizume,K.
  TITLE     Characterization of gene expression profiles in early bovine
            pregnancy using a custom cDNA microarray
  JOURNAL   Mol. Reprod. Dev. 65 (1), 9-18 (2003)
   PUBMED   12658628
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DT853625.1, AB017534.1 and DV828741.1.
FEATURES             Location/Qualifiers
     source          1..197
                     /organism="Bos taurus"
                     /db_xref="taxon:9913"
                     /chromosome="7"
                     /map="7"
                     /breed="Hereford"
     Protein         1..197
                     /product="glutathione peroxidase 4"
                     /EC_number="1.11.1.12"
                     /note="phospholipid hydroperoxide glutathione peroxidase"
                     /calculated_mol_wt=22109
     CDS             1..197
                     /gene="GPX4"
                     /gene_synonym="PHGPx"
                     /coded_by="NM_174770.3:91..684"
                     /selenocysteine
                     /db_xref="GeneID:286809"
ORIGIN      
        1 msfsrlyrll kpallcgala apglastmca srddwrcars mhefsakdid grmvnldkyr
       61 ghvcivtnva squgktdvny tqlvdlhary aecglrilaf pcnqfgrqep gsnaeikefa
      121 agynvkfdlf skicvngdda hplwkwmkvq pkgrgmlgna ikwnftkfli dkngcvvkry
      181 gpmeeplvie kdlpcyl
//