LOCUS       NP_776931                455 aa            linear   MAM 22-OCT-2008
DEFINITION  branched chain keto acid dehydrogenase E1, alpha polypeptide [Bos
            taurus].
ACCESSION   NP_776931
VERSION     NP_776931.1  GI:27806229
DBSOURCE    REFSEQ: accession NM_174506.1
KEYWORDS    .
SOURCE      Bos taurus (cattle)
  ORGANISM  Bos taurus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
            Pecora; Bovidae; Bovinae; Bos.
REFERENCE   1  (residues 1 to 455)
  AUTHORS   Hu,C.W., Lau,K.S., Griffin,T.A., Chuang,J.L., Fisher,C.W., Cox,R.P.
            and Chuang,D.T.
  TITLE     Isolation and sequencing of a cDNA encoding the decarboxylase
            (E1)alpha precursor of bovine branched-chain alpha-keto acid
            dehydrogenase complex. Expression of E1 alpha mRNA and subunit in
            maple-syrup-urine-disease and 3T3-L1 cells
  JOURNAL   J. Biol. Chem. 263 (18), 9007-9014 (1988)
   PUBMED   3379058
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J03759.1.
FEATURES             Location/Qualifiers
     source          1..455
                     /organism="Bos taurus"
                     /db_xref="taxon:9913"
                     /chromosome="18"
                     /map="18"
     Protein         1..455
                     /product="branched chain keto acid dehydrogenase E1, alpha
                     polypeptide"
                     /EC_number="1.2.4.4"
                     /note="branched chain keto acid dehydrogenase E1, alpha
                     polypeptide (maple syrup urine disease)"
     sig_peptide     1..55
                     /note="alpha-keto acid dehydrogenase signal peptide"
                     /calculated_mol_wt=6174
     mat_peptide     56..455
                     /product="alpha-keto acid dehydrogenase"
                     /calculated_mol_wt=45522
     CDS             1..455
                     /gene="BCKDHA"
                     /coded_by="NM_174506.1:101..1468"
                     /db_xref="GeneID:282149"
ORIGIN      
        1 mqgsakmama vavavarvwr psrglgrtgl pllrllgarg larfhphrwq qqqhfssldd
       61 kpqfpgasae fidklefiqp nvisgipiyr vmdrqgqiin psedphlpqe kvlkfyksmt
      121 llntmdrily esqrqgrisf ymtnygeegt hvgsaaaldd tdlvfgqyre agvlmyrdyp
      181 lelfmaqcyg nvsdlgkgrq mpvhygcrer hfvtisspla tqipqavgaa yaakrananr
      241 vvicyfgega asegdahagf nfaatlecpi iffcrnngya istptseqyr gdgiaargpg
      301 ygilsirvdg ndvfavynat kearrravae nqpflieamt yrighhstsd dssayrsvde
      361 vnywdkqdhp isrlrhhlqs rgwwddeqek awrkqsrkkv meafeqaerk lkpnpslifs
      421 dvyqempaql rkqqeslarh lqtygehypl dhfek
//