LOCUS       NP_776501                205 aa            linear   MAM 22-OCT-2008
DEFINITION  glutathione peroxidase 1 [Bos taurus].
ACCESSION   NP_776501
VERSION     NP_776501.1  GI:27806591
DBSOURCE    REFSEQ: accession NM_174076.3
KEYWORDS    .
SOURCE      Bos taurus (cattle)
  ORGANISM  Bos taurus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
            Pecora; Bovidae; Bovinae; Bos.
REFERENCE   1  (residues 1 to 205)
  AUTHORS   Handy,D.E., Hang,G., Scolaro,J., Metes,N., Razaq,N., Yang,Y. and
            Loscalzo,J.
  TITLE     Aminoglycosides decrease glutathione peroxidase-1 activity by
            interfering with selenocysteine incorporation
  JOURNAL   J. Biol. Chem. 281 (6), 3382-3388 (2006)
   PUBMED   16354666
  REMARK    GeneRIF: glutathione peroxidase-1 activity is decreased by
            aminoglycosides through interference with selenocysteine
            incorporation
REFERENCE   2  (residues 1 to 205)
  AUTHORS   Handy,D.E., Zhang,Y. and Loscalzo,J.
  TITLE     Homocysteine down-regulates cellular glutathione peroxidase (GPx1)
            by decreasing translation
  JOURNAL   J. Biol. Chem. 280 (16), 15518-15525 (2005)
   PUBMED   15734734
  REMARK    GeneRIF: homocysteine decreases GPx1 activity by altering the
            translational mechanism
REFERENCE   3  (residues 1 to 205)
  AUTHORS   Ishiwata,H., Katsuma,S., Kizaki,K., Patel,O.V., Nakano,H.,
            Takahashi,T., Imai,K., Hirasawa,A., Shiojima,S., Ikawa,H.,
            Suzuki,Y., Tsujimoto,G., Izaike,Y., Todoroki,J. and Hashizume,K.
  TITLE     Characterization of gene expression profiles in early bovine
            pregnancy using a custom cDNA microarray
  JOURNAL   Mol. Reprod. Dev. 65 (1), 9-18 (2003)
   PUBMED   12658628
REFERENCE   4  (residues 1 to 205)
  AUTHORS   Mullenbach,G.T., Tabrizi,A., Irvine,B.D., Bell,G.I., Tainer,J.A.
            and Hallewell,R.A.
  TITLE     Selenocysteine's mechanism of incorporation and evolution revealed
            in cDNAs of three glutathione peroxidases
  JOURNAL   Protein Eng. 2 (3), 239-246 (1988)
   PUBMED   2976939
REFERENCE   5  (residues 1 to 205)
  AUTHORS   Gunzler,W.A., Steffens,G.J., Grossmann,A., Kim,S.M., Otting,F.,
            Wendel,A. and Flohe,L.
  TITLE     The amino-acid sequence of bovine glutathione peroxidase
  JOURNAL   Hoppe-Seyler's Z. Physiol. Chem. 365 (2), 195-212 (1984)
   PUBMED   6714945
REFERENCE   6  (residues 1 to 205)
  AUTHORS   Epp,O., Ladenstein,R. and Wendel,A.
  TITLE     The refined structure of the selenoenzyme glutathione peroxidase at
            0.2-nm resolution
  JOURNAL   Eur. J. Biochem. 133 (1), 51-69 (1983)
   PUBMED   6852035
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EE243568.1, X13684.1 and CK969193.1.
FEATURES             Location/Qualifiers
     source          1..205
                     /organism="Bos taurus"
                     /db_xref="taxon:9913"
                     /chromosome="22"
                     /map="22"
     Protein         1..205
                     /product="glutathione peroxidase 1"
                     /EC_number="1.11.1.9"
                     /calculated_mol_wt=22528
     CDS             1..205
                     /gene="GPX1"
                     /coded_by="NM_174076.3:89..706"
                     /selenocysteine
                     /db_xref="GeneID:281209"
ORIGIN      
        1 mcaaqrsaaa laaaaprtvy afsarplagg epfnlsslrg kvllienvas lugttvrdyt
       61 qmndlqrrlg prglvvlgfp cnqfghqena kneeilnclk yvrpgggfep nfmlfekcev
      121 ngekahplfa flrevlptps ddatalmtdp kfitwspvcr ndvswnfekf lvgpdgvpvr
      181 rysrrfltid iepdietlls qgasa
//