LOCUS       NP_776368               1086 aa            linear   MAM 22-OCT-2008
DEFINITION  nicotinamide nucleotide transhydrogenase [Bos taurus].
ACCESSION   NP_776368 XP_593627
VERSION     NP_776368.1  GI:27806831
DBSOURCE    REFSEQ: accession NM_173943.2
KEYWORDS    .
SOURCE      Bos taurus (cattle)
  ORGANISM  Bos taurus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
            Pecora; Bovidae; Bovinae; Bos.
REFERENCE   1  (residues 1 to 1086)
  AUTHORS   Prasad,G.S., Sridhar,V., Yamaguchi,M., Hatefi,Y. and Stout,C.D.
  TITLE     Crystal structure of transhydrogenase domain III at 1.2 A
            resolution
  JOURNAL   Nat. Struct. Biol. 6 (12), 1126-1131 (1999)
   PUBMED   10581554
REFERENCE   2  (residues 1 to 1086)
  AUTHORS   Holmberg,E., Olausson,T., Hultman,T., Rydstrom,J., Ahmad,S.,
            Glavas,N.A. and Bragg,P.D.
  TITLE     Prediction and site-specific mutagenesis of residues in
            transmembrane alpha-helices of proton-pumping nicotinamide
            nucleotide transhydrogenases from Escherichia coli and bovine heart
            mitochondria
  JOURNAL   Biochemistry 33 (24), 7691-7700 (1994)
   PUBMED   8011636
REFERENCE   3  (residues 1 to 1086)
  AUTHORS   Yamaguchi,M. and Hatefi,Y.
  TITLE     Mitochondrial energy-linked nicotinamide nucleotide
            transhydrogenase. Membrane topography of the bovine enzyme
  JOURNAL   J. Biol. Chem. 266 (9), 5728-5735 (1991)
   PUBMED   2005110
REFERENCE   4  (residues 1 to 1086)
  AUTHORS   Yamaguchi,M., Hatefi,Y., Trach,K. and Hoch,J.A.
  TITLE     Amino acid sequence of the signal peptide of mitochondrial
            nicotinamide nucleotide transhydrogenase as determined from the
            sequence of its messenger RNA
  JOURNAL   Biochem. Biophys. Res. Commun. 157 (1), 24-29 (1988)
   PUBMED   3196335
REFERENCE   5  (residues 1 to 1086)
  AUTHORS   Yamaguchi,M., Hatefi,Y., Trach,K. and Hoch,J.A.
  TITLE     The primary structure of the mitochondrial energy-linked
            nicotinamide nucleotide transhydrogenase deduced from the sequence
            of cDNA clones
  JOURNAL   J. Biol. Chem. 263 (6), 2761-2767 (1988)
   PUBMED   3277960
REFERENCE   6  (residues 1 to 1086)
  AUTHORS   Wakabayashi,S. and Hatefi,Y.
  TITLE     Characterization of the substrate-binding sites of the
            mitochondrial nicotinamide nucleotide transhydrogenase
  JOURNAL   Biochem. Int. 15 (5), 915-924 (1987)
   PUBMED   3325062
REFERENCE   7  (residues 1 to 1086)
  AUTHORS   Wakabayashi,S. and Hatefi,Y.
  TITLE     Amino acid sequence of the NAD (H)--binding region of the
            mitochondrial nicotinamide nucleotide transhydrogenase modified by
            N,N'-dicyclohexylcarbodiimide
  JOURNAL   Biochem. Int. 15 (3), 667-675 (1987)
   PUBMED   3426633
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J03534.1.
            On Mar 29, 2005 this sequence version replaced gi:61883303.
FEATURES             Location/Qualifiers
     source          1..1086
                     /organism="Bos taurus"
                     /db_xref="taxon:9913"
                     /chromosome="20"
                     /map="20"
     Protein         1..1086
                     /product="nicotinamide nucleotide transhydrogenase"
                     /EC_number="1.6.1.2"
                     /note="pyridine nucleotide transhydrogenase"
     sig_peptide     1..43
                     /calculated_mol_wt=4833
     mat_peptide     44..1086
                     /product="nicotinamide nucleotide transhydrogenase"
                     /calculated_mol_wt=109039
     CDS             1..1086
                     /gene="NNT"
                     /coded_by="NM_173943.2:55..3315"
                     /db_xref="GeneID:280878"
ORIGIN      
        1 manllktvvt gcscpflsnl gsckvlpgkk nflrtfhthr ilwcsapvkp gipykqltvg
       61 vpkeifqnek rvalspagvq alvkqgfnvv vesgageask fsddhyraag aqiqgakevl
      121 asdlvvkvra pmlnptlgvh eadllktsgt lisfiypaqn pdllnklskr kttvlamdqv
      181 prvtiaqgyd alssmaniag ykavvlaanh fgrfftgqit aagkvppaki livgggvagl
      241 asagaaksmg aivrgfdtra aaleqfkslg aeplevdlke sgegqggyak emskefieae
      301 mklfaqqcke vdilistali pgkkapilfn kemiesmkeg svvvdlaaea ggnfettkpg
      361 elyvhkgith igytdlpsrm atqastlysn nitkllkais pdkdnfyfev kddfdfgtmg
      421 hvirgtvvmk dgqvifpapt pknipqgapv kqktvaelea ekaatitpfr ktmtsasvyt
      481 agltgilglg iaapnlafsq mvttfglagi vgyhtvwgvt palhsplmsv tnaisgltav
      541 gglvlmgghl ypsttsqgla alatfissvn iaggflvtqr mldmfkrptd ppeynylyll
      601 pagtfvggyl aslysgynie qimylgsglc cvgalaglst qgtarlgnal gmigvaggla
      661 atlgglkpcp ellaqmsgam alggtiglti akriqisdlp qlvaafhslv glaavltcia
      721 eyiieyphfa tdaaanltki vaylgtyigg vtfsgslvay gklqgilksa plllpgrhll
      781 nagllagsvg giipfmmdps fttgitclgs vsalsavmgv tltaaiggad mpvvitvlns
      841 ysgwalcaeg fllnnnllti vgaligssga ilsyimcvam nrslanvilg gygttstagg
      901 kpmeisgtht einldnaidm ireansiiit pgyglcaaka qypiadlvkm lseqgkkvrf
      961 gihpvagrmp gqlnvllaea gvpydivlem deinhdfpdt dlvlvigand tvnsaaqedp
     1021 nsiiagmpvl evwkskqviv mkrslgvgya avdnpifykp ntamllgdak ktcdalqakv
     1081 resyqk
//