LOCUS       NP_776249                414 aa            linear   PRI 14-SEP-2008
DEFINITION  serine (or cysteine) proteinase inhibitor, clade A (alpha-1
            antiproteinase, antitrypsin), member 12 [Homo sapiens].
ACCESSION   NP_776249
VERSION     NP_776249.1  GI:27777657
DBSOURCE    REFSEQ: accession NM_173850.2
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 414)
  AUTHORS   Kempf,K., Rose,B., Illig,T., Rathmann,W., Strassburger,K.,
            Thorand,B., Meisinger,C., Wichmann,H.E., Herder,C. and Vollmert,C.
  TITLE     Vaspin (SERPINA12) Genotypes and Risk of Type 2 Diabetes: Results
            from the MONICA/KORA studies
  JOURNAL   Exp. Clin. Endocrinol. Diabetes (2008) In press
   PUBMED   18726871
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 414)
  AUTHORS   Tan,B.K., Heutling,D., Chen,J., Farhatullah,S., Adya,R., Keay,S.D.,
            Kennedy,C.R., Lehnert,H. and Randeva,H.S.
  TITLE     Metformin decreases the adipokine vaspin in overweight women with
            polycystic ovary syndrome concomitant with improvement in insulin
            sensitivity and a decrease in insulin resistance
  JOURNAL   Diabetes 57 (6), 1501-1507 (2008)
   PUBMED   18375437
  REMARK    GeneRIF: Elevated serum and omental adipose tissue levels of vaspin
            in overweight polycystic ovary syndrome women and ex vivo
            regulation of vaspin expression.
REFERENCE   3  (residues 1 to 414)
  AUTHORS   Youn,B.S., Kloting,N., Kratzsch,J., Lee,N., Park,J.W., Song,E.S.,
            Ruschke,K., Oberbach,A., Fasshauer,M., Stumvoll,M. and Bluher,M.
  TITLE     Serum vaspin concentrations in human obesity and type 2 diabetes
  JOURNAL   Diabetes 57 (2), 372-377 (2008)
   PUBMED   17991760
  REMARK    GeneRIF: Low circulating vaspin correlates with a high fitness
            level, whereas physical training in untrained individuals causes
            increased vaspin serum concentrations.
REFERENCE   4  (residues 1 to 414)
  AUTHORS   Kloting,N., Berndt,J., Kralisch,S., Kovacs,P., Fasshauer,M.,
            Schon,M.R., Stumvoll,M. and Bluher,M.
  TITLE     Vaspin gene expression in human adipose tissue: association with
            obesity and type 2 diabetes
  JOURNAL   Biochem. Biophys. Res. Commun. 339 (1), 430-436 (2006)
   PUBMED   16298335
  REMARK    GeneRIF: Induction of human vaspin mRNA expression in adipose
            tissue is regulated in a fat depot-specific manner and could be
            associated with parameters of obesity, insulin resistance, and
            glucose metabolism.
REFERENCE   5  (residues 1 to 414)
  AUTHORS   Hida,K., Wada,J., Eguchi,J., Zhang,H., Baba,M., Seida,A.,
            Hashimoto,I., Okada,T., Yasuhara,A., Nakatsuka,A., Shikata,K.,
            Hourai,S., Futami,J., Watanabe,E., Matsuki,Y., Hiramatsu,R.,
            Akagi,S., Makino,H. and Kanwar,Y.S.
  TITLE     Visceral adipose tissue-derived serine protease inhibitor: a unique
            insulin-sensitizing adipocytokine in obesity
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 102 (30), 10610-10615 (2005)
   PUBMED   16030142
REFERENCE   6  (residues 1 to 414)
  AUTHORS   Namciu,S.J., Friedman,R.D., Marsden,M.D., Sarausad,L.M.,
            Jasoni,C.L. and Fournier,R.E.
  TITLE     Sequence organization and matrix attachment regions of the human
            serine protease inhibitor gene cluster at 14q32.1
  JOURNAL   Mamm. Genome 15 (3), 162-178 (2004)
   PUBMED   15014966
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC040857.1.
FEATURES             Location/Qualifiers
     source          1..414
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.13"
     Protein         1..414
                     /product="serine (or cysteine) proteinase inhibitor, clade
                     A (alpha-1 antiproteinase, antitrypsin), member 12"
                     /note="visceral adipose-specific SERPIN; vaspin"
                     /calculated_mol_wt=47044
     CDS             1..414
                     /gene="SERPINA12"
                     /gene_synonym="OL-64"
                     /coded_by="NM_173850.2:797..2041"
                     /db_xref="CCDS:CCDS9926.1"
                     /db_xref="GeneID:145264"
                     /db_xref="HGNC:18359"
                     /db_xref="HPRD:18038"
ORIGIN      
        1 mnptlglaif lavlltvkgl lkpsfsprny kalsevqgwk qrmaakelar qnmdlgfkll
       61 kklafynpgr niflsplsis tafsmlclga qdstldeikq gfnfrkmpek dlhegfhyii
      121 heltqktqdl klsigntlfi dqrlqpqrkf ledaknfysa etiltnfqnl emaqkqindf
      181 isqkthgkin nlienidpgt vmllanyiff rarwkhefdp nvtkeedffl eknssvkvpm
      241 mfrsgiyqvg yddklsctil eipyqknita ifilpdegkl khlekglqvd tfsrwktlls
      301 rrvvdvsvpr lhmtgtfdlk ktlsyigvsk ifeehgdltk iaphrslkvg eavhkaelkm
      361 dergtegaag tgaqtlpmet plvvkidkpy llliysekip svlflgkivn pigk
//