LOCUS       NP_776211                485 aa            linear   ROD 22-OCT-2008
DEFINITION  tryptophan hydroxylase 2 [Rattus norvegicus].
ACCESSION   NP_776211
VERSION     NP_776211.1  GI:27753970
DBSOURCE    REFSEQ: accession NM_173839.2
KEYWORDS    .
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
            Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 485)
  AUTHORS   Abumaria,N., Ribic,A., Anacker,C., Fuchs,E. and Flugge,G.
  TITLE     Stress upregulates TPH1 but not TPH2 mRNA in the rat dorsal raphe
            nucleus: identification of two TPH2 mRNA splice variants
  JOURNAL   Cell. Mol. Neurobiol. 28 (3), 331-342 (2008)
   PUBMED   18197473
  REMARK    GeneRIF: Expression of both TPH2 splice variants is not affected by
            stress, neither in dorsal raphe nucleus nor in the pineal gland.
REFERENCE   2  (residues 1 to 485)
  AUTHORS   Shishkina,G.T., Kalinina,T.S. and Dygalo,N.N.
  TITLE     Up-regulation of tryptophan hydroxylase-2 mRNA in the rat brain by
            chronic fluoxetine treatment correlates with its antidepressant
            effect
  JOURNAL   Neuroscience 150 (2), 404-412 (2007)
   PUBMED   17950541
  REMARK    GeneRIF: The results of the present study suggest that TPH2 gene
            expression in the midbrain part of the DRN is implicated in
            depression and stress response, as well as in the antidepressant
            fluoxetine action.
REFERENCE   3  (residues 1 to 485)
  AUTHORS   Malek,Z.S., Sage,D., Pevet,P. and Raison,S.
  TITLE     Daily rhythm of tryptophan hydroxylase-2 messenger ribonucleic acid
            within raphe neurons is induced by corticoid daily surge and
            modulated by enhanced locomotor activity
  JOURNAL   Endocrinology 148 (11), 5165-5172 (2007)
   PUBMED   17595225
  REMARK    GeneRIF: Both endocrine and behavioral cues can modulate Tph2
            expression in dorsal and median raphe.
REFERENCE   4  (residues 1 to 485)
  AUTHORS   Clark,M.S., McDevitt,R.A. and Neumaier,J.F.
  TITLE     Quantitative mapping of tryptophan hydroxylase-2, 5-HT1A, 5-HT1B,
            and serotonin transporter expression across the anteroposterior
            axis of the rat dorsal and median raphe nuclei
  JOURNAL   J. Comp. Neurol. 498 (5), 611-623 (2006)
   PUBMED   16917826
  REMARK    GeneRIF: The tryptophan hydroxylase-2 expression across the
            anteroposterior axis of the rat dorsal and median raphe nuclei.
REFERENCE   5  (residues 1 to 485)
  AUTHORS   Malek,Z.S., Dardente,H., Pevet,P. and Raison,S.
  TITLE     Tissue-specific expression of tryptophan hydroxylase mRNAs in the
            rat midbrain: anatomical evidence and daily profiles
  JOURNAL   Eur. J. Neurosci. 22 (4), 895-901 (2005)
   PUBMED   16115212
  REMARK    GeneRIF: The circadian 5-HT synthesis within the serotonergic
            neurons projecting to the circadian system might be explained by
            the rhythmic transcription of the tph2 gene in raphe nuclei.
REFERENCE   6  (residues 1 to 485)
  AUTHORS   Liang,J., Wessel,J.H. III, Iuvone,P.M., Tosini,G. and Fukuhara,C.
  TITLE     Diurnal rhythms of tryptophan hydroxylase 1 and 2 mRNA expression
            in the rat retina
  JOURNAL   Neuroreport 15 (9), 1497-1500 (2004)
   PUBMED   15194882
  REMARK    GeneRIF: Tph1 and Tph2 transcripts showed robust diurnal rhythms of
            abundance, with highest levels at night.
REFERENCE   7  (residues 1 to 485)
  AUTHORS   Sugden,D.
  TITLE     Comparison of circadian expression of tryptophan hydroxylase
            isoform mRNAs in the rat pineal gland using real-time PCR
  JOURNAL   J. Neurochem. 86 (5), 1308-1311 (2003)
   PUBMED   12911638
  REMARK    GeneRIF: TPH1 mRNA expression was 105-fold more abundant in rat
            pineal than TPH2; TPH2 expression within the gland showed no
            significant variation with time of day and was very low.
REFERENCE   8  (residues 1 to 485)
  AUTHORS   Walther,D.J., Peter,J.U., Bashammakh,S., Hortnagl,H., Voits,M.,
            Fink,H. and Bader,M.
  TITLE     Synthesis of serotonin by a second tryptophan hydroxylase isoform
  JOURNAL   Science 299 (5603), 76 (2003)
   PUBMED   12511643
  REMARK    GeneRIF: a second tryptophan hydroxylase isoform detected in the
            brain
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY098915.1.
            
            Summary: isoform of tryptophan hydroxylase; may play a role in
            seratonin biosynthesis [RGD].
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     Protein         1..485
                     /product="tryptophan hydroxylase 2"
                     /EC_number="1.14.16.4"
                     /note="neuronal tryptophan hydroxylase"
                     /calculated_mol_wt=55490
     CDS             1..485
                     /gene="Tph2"
                     /gene_synonym="Ntph"
                     /coded_by="NM_173839.2:118..1575"
                     /db_xref="GeneID:317675"
                     /db_xref="RGD:631332"
ORIGIN      
        1 mqpammmfss kywarrglsl dsavpeehqi lggltqnkat asksedkrsg kdtsesskta
       61 vvfslknevg glvralrlfq ekhvnmlhie srrsrrrsse veifvdcecg ktefneliql
      121 lkfqttivtl nppdniwtee eeledvpwfp rkiseldrcs hrvlmygtel dadhpgfkdn
      181 vyrqrrkyfv dvamgykygq piprveytee etktwgvvfr elsklyptha creylknfpl
      241 ltkycgyred nvpqledvsm flkersgftv rpvagylspr dflaglayrv fhctqyvrhg
      301 sdplytpepd tchellghvp lladpkfaqf sqeiglaslg asdedvqkla tcyfftiefg
      361 lckqegqlra ygagllssig elkhalsdka cvkafdpktt clqeclittf qdayfvsesf
      421 eeakekmrdf aksitrpfsv yfnpytqsie ilkdtrsien vvqdlrsdln tvcdalnkmn
      481 qylgi
//