LOCUS NP_775547 797 aa linear ROD 30-NOV-2008
DEFINITION hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) [Mus
musculus].
ACCESSION NP_775547
VERSION NP_775547.2 GI:31982147
DBSOURCE REFSEQ: accession NM_173371.3
KEYWORDS .
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
Sciurognathi; Muroidea; Muridae; Murinae; Mus.
REFERENCE 1 (residues 1 to 797)
AUTHORS Swali,A., Walker,E.A., Lavery,G.G., Tomlinson,J.W. and Stewart,P.M.
TITLE 11beta-Hydroxysteroid dehydrogenase type 1 regulates insulin and
glucagon secretion in pancreatic islets
JOURNAL Diabetologia 51 (11), 2003-2011 (2008)
PUBMED 18779947
REFERENCE 2 (residues 1 to 797)
AUTHORS Bujalska,I.J., Hewitt,K.N., Hauton,D., Lavery,G.G., Tomlinson,J.W.,
Walker,E.A. and Stewart,P.M.
TITLE Lack of hexose-6-phosphate dehydrogenase impairs lipid mobilization
from mouse adipose tissue
JOURNAL Endocrinology 149 (5), 2584-2591 (2008)
PUBMED 18218694
REMARK GeneRIF: Lack of hexose-6-phosphate dehydrogenase impairs lipid
mobilization from mouse adipose tissue.
REFERENCE 3 (residues 1 to 797)
AUTHORS Lavery,G.G., Walker,E.A., Turan,N., Rogoff,D., Ryder,J.W.,
Shelton,J.M., Richardson,J.A., Falciani,F., White,P.C.,
Stewart,P.M., Parker,K.L. and McMillan,D.R.
TITLE Deletion of hexose-6-phosphate dehydrogenase activates the unfolded
protein response pathway and induces skeletal myopathy
JOURNAL J. Biol. Chem. 283 (13), 8453-8461 (2008)
PUBMED 18222920
REMARK GeneRIF: absence of H6PD induces a progressive myopathy by altering
the sarcoplasmic reticulum redox state
REFERENCE 4 (residues 1 to 797)
AUTHORS Lavery,G.G., Hauton,D., Hewitt,K.N., Brice,S.M., Sherlock,M.,
Walker,E.A. and Stewart,P.M.
TITLE Hypoglycemia with enhanced hepatic glycogen synthesis in
recombinant mice lacking hexose-6-phosphate dehydrogenase
JOURNAL Endocrinology 148 (12), 6100-6106 (2007)
PUBMED 17823265
REMARK GeneRIF: Data postulate that increased glycogen synthesis may
reflect increased flux of glucose-6-phosphate (H6PDH substrate)
through to glycogen in the absence of hexose-6-phosphate
dehydrogenase mediated metabolism.
REFERENCE 5 (residues 1 to 797)
AUTHORS Rogoff,D., Ryder,J.W., Black,K., Yan,Z., Burgess,S.C.,
McMillan,D.R. and White,P.C.
TITLE Abnormalities of glucose homeostasis and the
hypothalamic-pituitary-adrenal axis in mice lacking
hexose-6-phosphate dehydrogenase
JOURNAL Endocrinology 148 (10), 5072-5080 (2007)
PUBMED 17656460
REMARK GeneRIF: Both glucose output and glucose use are abnormal in mice
lacking hexose-6-phosphate dehydrogenase.
REFERENCE 6 (residues 1 to 797)
AUTHORS Morse,H.C. III, Chused,T.M., Hartley,J.W., Mathieson,B.J.,
Sharrow,S.O. and Taylor,B.A.
TITLE Expression of xenotropic murine leukemia viruses as cell-surface
gp70 in genetic crosses between strains DBA/2 and C57BL/6
JOURNAL J. Exp. Med. 149 (5), 1183-1196 (1979)
PUBMED 221612
REFERENCE 7 (residues 1 to 797)
AUTHORS Holmes,R.S.
TITLE Genetics and ontogeny of aldehyde dehydrogenase isozymes in the
mouse: localization of Ahd-1 encoding the mitochondrial isozyme on
chromosome 4
JOURNAL Biochem. Genet. 16 (11-12), 1207-1218 (1978)
PUBMED 751648
REFERENCE 8 (residues 1 to 797)
AUTHORS Taylor,B.A., Bedigian,H.G. and Meier,H.
TITLE Genetic studies of the Fv-1 locus of mice: linkage with Gpd-1 in
recombinant inbred lines
JOURNAL J. Virol. 23 (1), 106-109 (1977)
PUBMED 196096
REFERENCE 9 (residues 1 to 797)
AUTHORS Chapman,V.M.
TITLE 6-Phosphogluconate dehydrogenase (PGD) genetics in the mouse:
linkage with metabolically related enzyme loci
JOURNAL Biochem. Genet. 13 (11-12), 849-856 (1975)
PUBMED 1200981
REFERENCE 10 (residues 1 to 797)
AUTHORS Potter,M., Pumphrey,J.G. and Bailey,D.W.
TITLE Genetics of susceptibility to plasmacytoma induction. I. BALB/cAnN
(C), C57BL/6N (B6), C57BL/Ka (BK), (C times B6)F1, (C times BK)F1,
and C times B recombinant-inbred strains
JOURNAL J. Natl. Cancer Inst. 54 (6), 1413-1417 (1975)
PUBMED 1133851
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from AK045199.1.
On Jun 19, 2003 this sequence version replaced gi:27734064.
Sequence Note: removed 1 base from the 5' end that did not align to
the reference genome assembly.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..797
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="4"
/map="4 78.4 cM"
Protein 1..797
/product="hexose-6-phosphate dehydrogenase (glucose
1-dehydrogenase)"
/EC_number="1.1.1.47"
/EC_number="3.1.1.31"
/note="glucose-6-phosphate dehydrogenase 1; glucose
1-dehydrogenase"
/calculated_mol_wt=89779
CDS 1..797
/gene="H6pd"
/gene_synonym="Gpd1"
/gene_synonym="G6pd1"
/gene_synonym="Gpd-1"
/gene_synonym="AI785303"
/coded_by="NM_173371.3:269..2662"
/db_xref="CCDS:CCDS18967.1"
/db_xref="GeneID:100198"
/db_xref="MGI:2140356"
ORIGIN
1 mkhtgiwkml laamclallg clqaqelkgh vsiillgatg dlakkylwqg lfqlyldeag
61 kghsfsfhga altapqqgqk lmdkvlesls cpkdlvpsrc delkgqflql sqyrqlktve
121 dyqtlnkdie tqvqqdglwe agrifyfsvp pfayadiarn insscrphpg awlrvvfekp
181 fghdhlsaqq laselgsffq eeemyrvdhy lgkqavaqil pfrdqnrkal dglwnrhhve
241 rveiilketi daegrasfye eygvirdtlq nhlteiltlv amelplniss saavlqhklw
301 afqalrglqk ssailgqyqa ysgqvrrelq kpdgfqsltp tfagvlvhid nlrwegvpfi
361 lmsgkalder vgyvrivfkn rayctqserh wvpeqsrclp qqiifyighg elghpailvs
421 rnlfkpslpt qkwkevqdqp glrlfgrpls dyyayrpvre qdaystllsh ifhcrkesfi
481 ttenllaswv fwtplldsla fevprpypgg aengqlldfe fsggqltfsq qqlevlipdl
541 gsvpkpsdfq vlgaryrqsp litawpeeli sklasdieaa avqavrhfgk fhlalsggss
601 pialfqqlat ghysfpwaht hlwlvdercv plsdpdsnfq glqahllqhv rvpyynihpm
661 pvhlhqrlca eedqgaqtya seisalvans sfdlvllgmg tdghtaslfp qsptgldgdq
721 lvvltespfr phqrmslslp linrakkvav lvmgrtkrei ttlvsrvghe pkkwpisgvv
781 plsgqlvwym dyeaflg
//