LOCUS       NP_766599                452 aa            linear   ROD 22-OCT-2008
DEFINITION  isocitrate dehydrogenase 2 (NADP+), mitochondrial [Mus musculus].
ACCESSION   NP_766599 NP_032348
VERSION     NP_766599.1  GI:27370516
DBSOURCE    REFSEQ: accession NM_173011.1
KEYWORDS    .
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
            Sciurognathi; Muroidea; Muridae; Murinae; Mus.
REFERENCE   1  (residues 1 to 452)
  AUTHORS   Cankaya,M., Hernandez,A.M., Ciftci,M., Beydemir,S., Ozdemir,H.,
            Budak,H., Gulcin,I., Comakli,V., Emircupani,T., Ekinci,D., Kuzu,M.,
            Jiang,Q., Eichele,G. and Kufrevioglu,O.I.
  TITLE     An analysis of expression patterns of genes encoding proteins with
            catalytic activities
  JOURNAL   BMC Genomics 8, 232 (2007)
   PUBMED   17626619
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 452)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol. Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   3  (residues 1 to 452)
  AUTHORS   Shin,A.H., Kil,I.S., Yang,E.S., Huh,T.L., Yang,C.H. and Park,J.W.
  TITLE     Regulation of high glucose-induced apoptosis by mitochondrial
            NADP+-dependent isocitrate dehydrogenase
  JOURNAL   Biochem. Biophys. Res. Commun. 325 (1), 32-38 (2004)
   PUBMED   15522197
  REMARK    GeneRIF: Results suggest that mitochondrial NADP(+)-dependent
            isocitrate dehydrogenase plays a role in apoptosis induced by high
            glucose and may contribute to various pathologies associated with
            the long-term complications of diabetes.
REFERENCE   4  (residues 1 to 452)
  AUTHORS   Visel,A., Thaller,C. and Eichele,G.
  TITLE     GenePaint.org: an atlas of gene expression patterns in the mouse
            embryo
  JOURNAL   Nucleic Acids Res. 32 (DATABASE ISSUE), D552-D556 (2004)
   PUBMED   14681479
REFERENCE   5  (residues 1 to 452)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   6  (residues 1 to 452)
  AUTHORS   Bonhomme,F., Catalan,J., Britton-Davidian,J., Chapman,V.M.,
            Moriwaki,K., Nevo,E. and Thaler,L.
  TITLE     Biochemical diversity and evolution in the genus Mus
  JOURNAL   Biochem. Genet. 22 (3-4), 275-303 (1984)
   PUBMED   6375655
  REMARK    Review article
REFERENCE   7  (residues 1 to 452)
  AUTHORS   Stallings,R.L. and Siciliano,M.J.
  TITLE     Confirmational, provisional, and/or regional assignment of 15
            enzyme loci onto Chinese hamster autosomes 1, 2, and 7
  JOURNAL   Somatic Cell Genet. 7 (6), 683-698 (1981)
   PUBMED   7323947
REFERENCE   8  (residues 1 to 452)
  AUTHORS   Lalley,P.A., Minna,J.D. and Francke,U.
  TITLE     Conservation of autosomal gene synteny groups in mouse and man
  JOURNAL   Nature 274 (5667), 160-163 (1978)
   PUBMED   662012
REFERENCE   9  (residues 1 to 452)
  AUTHORS   Lalley,P.A., Francke,U. and Minna,J.D.
  TITLE     Comparative gene mapping in man and mouse: assignment of the genes
            for lactate dehydrogenase-A, peptidase-D, and isocitrate
            dehydrogenase-2 to mouse chromosome 7
  JOURNAL   Cytogenet. Cell Genet. 22 (1-6), 577-580 (1978)
   PUBMED   752544
REFERENCE   10 (residues 1 to 452)
  AUTHORS   Krog,H.H., Wysocka,M., Kisielow,P. and Radzikowski,C.
  TITLE     Genetic characterization of important mouse strains used in cancer
            research
  JOURNAL   Hereditas 87 (2), 201-204 (1977)
   PUBMED   75870
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF212319.1.
            On Mar 11, 2003 this sequence version replaced gi:6680343.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the
            Entrez Gene record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 41.0 cM"
     Protein         1..452
                     /product="isocitrate dehydrogenase 2 (NADP+),
                     mitochondrial"
                     /EC_number="1.1.1.42"
                     /note="NADP+-specific isocitrate dehydrogenase"
                     /calculated_mol_wt=50803
     CDS             1..452
                     /gene="Idh2"
                     /gene_synonym="IDPm"
                     /gene_synonym="Idh-2"
                     /gene_synonym="E430004F23"
                     /coded_by="NM_173011.1:46..1404"
                     /db_xref="CCDS:CCDS39994.1"
                     /db_xref="GeneID:269951"
                     /db_xref="MGI:96414"
ORIGIN      
        1 magylravss lcrasgsart wapaaltvps wpeqprrhya ekrikvekpv vemdgdemtr
       61 iiwqfikekl ilphvdvqlk yfdlglpnrd qtndqvtids alatqkysva vkcatitpde
      121 arveefklkk mwkspngtir nilggtvfre piickniprl vpgwtkpiti grhahgdqyk
      181 atdfvvdrag tfklvftpkd gssakewevy nfpaggvgmg myntdesisg fahscfqysi
      241 qkkwplylst kntilkaydg rfkdifqeif dkhyktdfdr nkiwyehrli ddmvaqvlks
      301 sggfvwackn ydgdvqsdil aqgfgslglm tsvlvcpdgk tieaeaahgt vtrhyrehqk
      361 grptstnpia sifawtrgle hrgkldgnqd lirfaqtlek vcvqtvesga mtkdlagcih
      421 glsnvklneh flnttdfldt iksnldralg kq
//