LOCUS NP_766366 520 aa linear ROD 24-OCT-2008
DEFINITION amine oxidase (flavin-containing) [Mus musculus].
ACCESSION NP_766366
VERSION NP_766366.1 GI:27370154
DBSOURCE REFSEQ: accession NM_172778.1
KEYWORDS .
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
Sciurognathi; Muroidea; Muridae; Murinae; Mus.
REFERENCE 1 (residues 1 to 520)
AUTHORS Mallajosyula,J.K., Kaur,D., Chinta,S.J., Rajagopalan,S., Rane,A.,
Nicholls,D.G., Di Monte,D.A., Macarthur,H. and Andersen,J.K.
TITLE MAO-B elevation in mouse brain astrocytes results in Parkinson's
pathology
JOURNAL PLoS ONE 3 (2), E1616 (2008)
PUBMED 18286173
REMARK GeneRIF: Elevated astrocytic MAO-B mimicking age related increase
resulted in specific, selective and progressive loss of
dopaminergic neurons in the substantia nigra, accompanied by
decreases in mt complex I activity and increased mt oxidative
stress.
Publication Status: Online-Only
REFERENCE 2 (residues 1 to 520)
AUTHORS Yin,H.S., Chen,K., Kalpana,S. and Shih,J.C.
TITLE Differential effects of chronic amphetamine and baclofen
administration on cAMP levels and phosphorylation of CREB in
distinct brain regions of wild type and monoamine oxidase
B-deficient mice
JOURNAL Synapse 60 (8), 573-584 (2006)
PUBMED 16983645
REMARK GeneRIF: Moreover, MAOB is region-dependently involved in responses
of the brain to Amph and baclofen, supporting interactions between
GABA and monoamines.
REFERENCE 3 (residues 1 to 520)
AUTHORS Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
Zhao,Y.
TITLE Substrate and functional diversity of lysine acetylation revealed
by a proteomics survey
JOURNAL Mol. Cell 23 (4), 607-618 (2006)
PUBMED 16916647
REFERENCE 4 (residues 1 to 520)
AUTHORS Ou,X.M., Chen,K. and Shih,J.C.
TITLE Monoamine oxidase A and repressor R1 are involved in apoptotic
signaling pathway
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 103 (29), 10923-10928 (2006)
PUBMED 16829576
REFERENCE 5 (residues 1 to 520)
AUTHORS Hjerling-Leffler,J., Marmigere,F., Heglind,M., Cederberg,A.,
Koltzenburg,M., Enerback,S. and Ernfors,P.
TITLE The boundary cap: a source of neural crest stem cells that generate
multiple sensory neuron subtypes
JOURNAL Development 132 (11), 2623-2632 (2005)
PUBMED 15872002
REFERENCE 6 (residues 1 to 520)
AUTHORS Holschneider,D.P., Scremin,O.U., Huynh,L., Chen,K. and Shih,J.C.
TITLE Lack of protection from ischemic injury of monoamine oxidase
B-deficient mice following middle cerebral artery occlusion
JOURNAL Neurosci. Lett. 259 (3), 161-164 (1999)
PUBMED 10025583
REFERENCE 7 (residues 1 to 520)
AUTHORS Grimsby,J., Toth,M., Chen,K., Kumazawa,T., Klaidman,L., Adams,J.D.,
Karoum,F., Gal,J. and Shih,J.C.
TITLE Increased stress response and beta-phenylethylamine in
MAOB-deficient mice
JOURNAL Nat. Genet. 17 (2), 206-210 (1997)
PUBMED 9326944
REFERENCE 8 (residues 1 to 520)
AUTHORS Saura,J., Richards,J.G. and Mahy,N.
TITLE Differential age-related changes of MAO-A and MAO-B in mouse brain
and peripheral organs
JOURNAL Neurobiol. Aging 15 (4), 399-408 (1994)
PUBMED 7969716
REFERENCE 9 (residues 1 to 520)
AUTHORS Rao,V.L., Qureshi,I.A. and Butterworth,R.F.
TITLE Activities of monoamine oxidase-A and -B are altered in the brains
of congenitally hyperammonemic sparse-fur (spf) mice
JOURNAL Neurosci. Lett. 170 (1), 27-30 (1994)
PUBMED 8041507
REFERENCE 10 (residues 1 to 520)
AUTHORS Derry,J.M., Lan,N.C., Shih,J.C., Barnard,E.A. and Barnard,P.J.
TITLE Localization of monoamine oxidase A and B genes on the mouse X
chromosome
JOURNAL Nucleic Acids Res. 17 (20), 8403 (1989)
PUBMED 2573045
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AK054050.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..520
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="X"
/map="X 5.2 cM"
Protein 1..520
/product="amine oxidase (flavin-containing)"
/EC_number="1.4.3.4"
/calculated_mol_wt=58413
CDS 1..520
/gene="Maob"
/gene_synonym="MAO-B"
/gene_synonym="6330414K01Rik"
/coded_by="NM_172778.1:91..1653"
/db_xref="CCDS:CCDS40882.1"
/db_xref="GeneID:109731"
/db_xref="MGI:96916"
ORIGIN
1 msnksdvivv gggisgmaaa kllhdcglsv vvleardrvg grtytirnkn vkyvdlggsy
61 vgptqnrilr lakelglety kvneverlih fvkgksyafr gpfppvwnpi tyldnnnlwr
121 tmdemgqeip sdapwkapla eewdymtmke lldkicwtks tkqiatlfvn lcvtaethev
181 salwflwyvk qcggttriis ttnggqerkf iggsgqvser ikdilgdrvk lerpvihidq
241 tgenvivktl nheiyeakyv isaippalgm kihyspplpm lrnqlisrvp lgsvikcmvy
301 ykepfwrkkd fcgtmviege eapiaytldd tkpdgtyaai mgfilahkar klvrltkeer
361 lrklcelyak vlnsqealqp vhyeeknwce eqysggcytt yfppgilsqy grvlrqpvgk
421 iffagtetas hwsgymegav eageraarei lhaigkiped eiwqpepesl dvparpitst
481 flerhlpsvp gllklfgltt ilsatalgfl ahkrglfvhf
//