LOCUS       NP_766297                600 aa            linear   ROD 12-OCT-2008
DEFINITION  otopetrin 1 [Mus musculus].
ACCESSION   NP_766297
VERSION     NP_766297.2  GI:145208004
DBSOURCE    REFSEQ: accession NM_172709.3
KEYWORDS    .
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
            Sciurognathi; Muroidea; Muridae; Murinae; Mus.
REFERENCE   1  (residues 1 to 600)
  AUTHORS   Seale,P., Bjork,B., Yang,W., Kajimura,S., Chin,S., Kuang,S.,
            Scime,A., Devarakonda,S., Conroe,H.M., Erdjument-Bromage,H.,
            Tempst,P., Rudnicki,M.A., Beier,D.R. and Spiegelman,B.M.
  TITLE     PRDM16 controls a brown fat/skeletal muscle switch
  JOURNAL   Nature 454 (7207), 961-967 (2008)
   PUBMED   18719582
REFERENCE   2  (residues 1 to 600)
  AUTHORS   Zhao,X., Jones,S.M., Yamoah,E.N. and Lundberg,Y.W.
  TITLE     Otoconin-90 deletion leads to imbalance but normal hearing: a
            comparison with other otoconia mutants
  JOURNAL   Neuroscience 153 (1), 289-299 (2008)
   PUBMED   18355969
REFERENCE   3  (residues 1 to 600)
  AUTHORS   Besson,V., Nalesso,V., Herpin,A., Bizot,J.C., Messaddeq,N.,
            Romand,R., Puech,A., Blanquet,V. and Herault,Y.
  TITLE     Training and aging modulate the loss-of-balance phenotype observed
            in a new ENU-induced allele of Otopetrin1
  JOURNAL   Biol. Cell 97 (10), 787-798 (2005)
   PUBMED   15730345
REFERENCE   4  (residues 1 to 600)
  AUTHORS   de Caprona,M.D., Beisel,K.W., Nichols,D.H. and Fritzsch,B.
  TITLE     Partial behavioral compensation is revealed in balance tasked
            mutant mice lacking otoconia
  JOURNAL   Brain Res. Bull. 64 (4), 289-301 (2004)
   PUBMED   15561463
REFERENCE   5  (residues 1 to 600)
  AUTHORS   Jones,S.M., Erway,L.C., Johnson,K.R., Yu,H. and Jones,T.A.
  TITLE     Gravity receptor function in mice with graded otoconial
            deficiencies
  JOURNAL   Hear. Res. 191 (1-2), 34-40 (2004)
   PUBMED   15109702
  REMARK    Erratum:[Hear Res. 2004 Aug;194(1-2):143]
REFERENCE   6  (residues 1 to 600)
  AUTHORS   Hurle,B., Ignatova,E., Massironi,S.M., Mashimo,T., Rios,X.,
            Thalmann,I., Thalmann,R. and Ornitz,D.M.
  TITLE     Non-syndromic vestibular disorder with otoconial agenesis in
            tilted/mergulhador mice caused by mutations in otopetrin 1
  JOURNAL   Hum. Mol. Genet. 12 (7), 777-789 (2003)
   PUBMED   12651873
  REMARK    GeneRIF: a non-syndromic vestibular disorder with otoconial
            agenesis in tilted/mergulhador mice is caused by mutations in
            otopetrin 1
            GeneRIF: Otopetrin 1 encodes a multi-transmembrane domain protein
            expressed in the developing otocyst. Mouse mutants tilted and
            mergulhador carry recessive mutations in Otop1 that result in
            otoconial agenesis without causing collateral deafness.
REFERENCE   7  (residues 1 to 600)
  AUTHORS   Smith,M., Yuan Wang,X., Wolgemuth,D.J. and Murashov,A.K.
  TITLE     Development of the mouse vestibular system in the absence of
            gravity perception
  JOURNAL   Brain Res. Dev. Brain Res. 140 (1), 133-135 (2003)
   PUBMED   12524184
REFERENCE   8  (residues 1 to 600)
  AUTHORS   Hurle,B., Lane,K., Kenney,J., Tarantino,L.M., Bucan,M.,
            Brownstein,B.H. and Ornitz,D.M.
  TITLE     Physical mapping of the mouse tilted locus identifies an
            association between human deafness loci DFNA6/14 and vestibular
            system development
  JOURNAL   Genomics 77 (3), 189-199 (2001)
   PUBMED   11597144
REFERENCE   9  (residues 1 to 600)
  AUTHORS   Ying,H.C., Hurle,B., Wang,Y., Bohne,B.A., Wuerffel,M.K. and
            Ornitz,D.M.
  TITLE     High-resolution mapping of tlt, a mouse mutant lacking otoconia
  JOURNAL   Mamm. Genome 10 (6), 544-548 (1999)
   PUBMED   10341082
REFERENCE   10 (residues 1 to 600)
  AUTHORS   Ornitz,D.M., Bohne,B.A., Thalmann,I., Harding,G.W. and Thalmann,R.
  TITLE     Otoconial agenesis in tilted mutant mice
  JOURNAL   Hear. Res. 122 (1-2), 60-70 (1998)
   PUBMED   9714575
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF548337.1, AK040792.1 and EH101457.1.
            On Apr 13, 2007 this sequence version replaced gi:27370034.
FEATURES             Location/Qualifiers
     source          1..600
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 24.0 cM"
     Protein         1..600
                     /product="otopetrin 1"
                     /note="tilted"
                     /calculated_mol_wt=65624
     CDS             1..600
                     /gene="Otop1"
                     /gene_synonym="tlt"
                     /gene_synonym="Otp1"
                     /gene_synonym="A530025J20Rik"
                     /coded_by="NM_172709.3:25..1827"
                     /db_xref="GeneID:21906"
                     /db_xref="MGI:2388363"
ORIGIN      
        1 mpggpgapss paassgssra apsgiaacpl sppplargsp qasgprrgas vpqklaetls
       61 sqyglnvfva gllfllawav hatgvgksdl lcvltalmll qllwmlwyvg rsymqrrlir
      121 pkdthagarw lrgsitlfaf itvvlgclkv ayfigfsecl sategvfpvt havhtllqvy
      181 flwghakdii msfktlerfg vihsvftnll lwansvlnes khqlnehker litlgfgnit
      241 ivlddhtpqc nctppalcsa lshgiyylyp fnieyqilas tmlyvlwkni grrvdssqhq
      301 kmqcrfdgvl vgsvlgltvl aatiavvvvy mihigrsksk sesalimfyl yaitvlllmg
      361 aaglvgswiy rvdeksldes knparkldvd llvatgsgsw llswgsilai acaetrppyt
      421 wynlpysvlv ivekyvqnif iiesvhlepe gvpedvrtlr vvtvcsseaa alaastlgsq
      481 gmaqdgspav ngnlclqqrc gkedqesgwe gatgttrcld flqggmkrrl lrnitaflfl
      541 cnislwippa fgcrpeydng leeivfgfep wiivvnlamp fsifyrmhaa aalfevycki
//