LOCUS       NP_570899                956 aa            linear   PRI 28-SEP-2008
DEFINITION  angiomotin like 1 [Homo sapiens].
ACCESSION   NP_570899
VERSION     NP_570899.1  GI:22027646
DBSOURCE    REFSEQ: accession NM_130847.2
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 956)
  AUTHORS   Barbe,L., Lundberg,E., Oksvold,P., Stenius,A., Lewin,E.,
            Bjorling,E., Asplund,A., Ponten,F., Brismar,H., Uhlen,M. and
            Andersson-Svahn,H.
  TITLE     Toward a confocal subcellular atlas of the human proteome
  JOURNAL   Mol. Cell Proteomics 7 (3), 499-508 (2008)
   PUBMED   18029348
REFERENCE   2  (residues 1 to 956)
  AUTHORS   Patrie,K.M.
  TITLE     Identification and characterization of a novel tight
            junction-associated family of proteins that interacts with a WW
            domain of MAGI-1
  JOURNAL   Biochim. Biophys. Acta 1745 (1), 131-144 (2005)
   PUBMED   16019084
REFERENCE   3  (residues 1 to 956)
  AUTHORS   Bratt,A., Wilson,W.J., Troyanovsky,B., Aase,K., Kessler,R., Van
            Meir,E.G. and Holmgren,L.
  TITLE     Angiomotin belongs to a novel protein family with conserved
            coiled-coil and PDZ binding domains
  JOURNAL   Gene 298 (1), 69-77 (2002)
   PUBMED   12406577
  REMARK    Erratum:[Gene. 2003 May 22;310;231. Meir, EG [corrected to Van
            Meir, EG]]
REFERENCE   4  (residues 1 to 956)
  AUTHORS   Nishimura,M., Kakizaki,M., Ono,Y., Morimoto,K., Takeuchi,M.,
            Inoue,Y., Imai,T. and Takai,Y.
  TITLE     JEAP, a novel component of tight junctions in exocrine cells
  JOURNAL   J. Biol. Chem. 277 (7), 5583-5587 (2002)
   PUBMED   11733531
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX648729.1, BC037539.1 and
            AP001152.4.
            
            Summary: The protein encoded by this gene is a peripheral membrane
            protein that is a component of tight junctions or TJs. TJs form an
            apical junctional structure and act to control paracellular
            permeability and maintain cell polarity. This protein is related to
            angiomotin, an angiostatin binding protein that regulates
            endothelial cell migration and capillary formation. [provided by
            RefSeq].
FEATURES             Location/Qualifiers
     source          1..956
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14.3"
     Protein         1..956
                     /product="angiomotin like 1"
                     /note="junction-enriched and associated protein"
                     /calculated_mol_wt=106444
     CDS             1..956
                     /gene="AMOTL1"
                     /gene_synonym="JEAP"
                     /coded_by="NM_130847.2:171..3041"
                     /db_xref="GeneID:154810"
                     /db_xref="HGNC:17811"
                     /db_xref="HPRD:12451"
ORIGIN      
        1 mwraklrrgt cepavkgsps acyspsspvq vledstyfsp dfqlysgrhe tsaltveats
       61 sirekvvedp lcnfhspnfl risevemrgs edaaagtvlq rliqeqlryg tptenmnlla
      121 iqhqatgsag pahptnnfss tenltqedpq mvyqsarqep qgqehqvdnt vmekqvrstq
      181 pqqnneelpt yeeakaqsqf frgqqqqqqq qgavghgyym aggtsqksrt egrptvnran
      241 sgqahkdeal kelkqghvrs lserimqlsl erngakqhlp gsgngkgfkv gggpspaqpa
      301 gkvldprgpp peypfktkqm mspvsktqeh glfygdqhpg mlhemvkpyp apqpvrtdva
      361 vlryqpppey gvtsrpcqlp fpstmqqhsp mssqtssasg plhsvslplp lpmalgapqp
      421 ppaaspsqql gpdafaiver aqqmveilte enrvlhqelq gyydnadklh kfekelqris
      481 eayeslvkst tkresldkam rnklegeirr lhdfnrdlrd rletanrqls sreyeghedk
      541 aaeghyasqn keflkekekl emelaavrta sedhrrhiei ldqalsnaqa rvikleeelr
      601 ekqayvekve klqqaltqlq sacekreqme rrlrtwlere ldalrtqqkh gngqpanmpe
      661 ynapallelv rekeerilal eadmtkweqk yleestirhf amnaaataaa erdttiinhs
      721 rngsygessl eahiwqeeee vvqanrrcqd meytiknlha kiiekdamik vlqqrsrkda
      781 gktdssslrp arsvpsiaaa tgthsrqtsl tssqlaeekk eektwkgsig lllgkehheh
      841 asapllpppp tsalssiast taassahakt gskdsstqtd ksaelfwpsm aslpsrgrls
      901 ttpahspvlk hpaakgtaek lenspghgks pdhrgrvssl lhkpefpdge mmevli
//