LOCUS       NP_218226                421 aa            linear   BCT 19-NOV-2008
DEFINITION  aspartate kinase [Mycobacterium tuberculosis H37Rv].
ACCESSION   NP_218226
VERSION     NP_218226.1  GI:15610845
DBSOURCE    REFSEQ: accession NC_000962.2
KEYWORDS    complete genome.
SOURCE      Mycobacterium tuberculosis H37Rv
  ORGANISM  Mycobacterium tuberculosis H37Rv
            Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
            Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium
            tuberculosis complex.
REFERENCE   1
  AUTHORS   Camus,J.C., Pryor,M.J., Medigue,C. and Cole,S.T.
  TITLE     Re-annotation of the genome sequence of Mycobacterium tuberculosis
            H37Rv
  JOURNAL   Microbiology (Reading, Engl.) 148 (Pt 10), 2967-2973 (2002)
   PUBMED   12368430
REFERENCE   2  (residues 1 to 421)
  AUTHORS   Cole,S.T., Brosch,R., Parkhill,J., Garnier,T., Churcher,C.,
            Harris,D., Gordon,S.V., Eiglmeier,K., Gas,S., Barry,C.E. III,
            Tekaia,F., Badcock,K., Basham,D., Brown,D., Chillingworth,T.,
            Connor,R., Davies,R., Devlin,K., Feltwell,T., Gentles,S.,
            Hamlin,N., Holroyd,S., Hornsby,T., Jagels,K., Krogh,A., McLean,J.,
            Moule,S., Murphy,L., Oliver,K., Osborne,J., Quail,M.A.,
            Rajandream,M.A., Rogers,J., Rutter,S., Seeger,K., Skelton,J.,
            Squares,R., Squares,S., Sulston,J.E., Taylor,K., Whitehead,S. and
            Barrell,B.G.
  TITLE     Deciphering the biology of Mycobacterium tuberculosis from the
            complete genome sequence
  JOURNAL   Nature 393 (6685), 537-544 (1998)
   PUBMED   9634230
  REMARK    Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE   3  (residues 1 to 421)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (13-SEP-2001) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CAA18031.
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..421
                     /organism="Mycobacterium tuberculosis H37Rv"
                     /strain="H37Rv"
                     /db_xref="taxon:83332"
     Protein         1..421
                     /product="aspartate kinase"
                     /EC_number="2.7.2.4"
                     /function="INVOLVED AT THE FIRST STEP IN THE COMMON
                     BIOSYNTHETIC PATHWAY LEADING FROM ASP TO THE CELL WALL
                     PRECURSOR MESO-DIAMINOPIMELATE, TO LYS, TO MET, TO ILE AND
                     TO THR [CATALYTIC ACTIVITY: ATP + L-ASPARTATE = ADP +
                     4-PHOSPHO-L-ASPARTATE]. POSSIBLY ACTS IN TETRAMER
                     CONFIGURATION, TETRAMER CONSISTING OF TWO ALPHA (CATALYTIC
                     ACTIVITY) AND TWO BETA (FUNCTION NOT KNOWN) CHAINS."
                     /calculated_mol_wt=44331
     CDS             1..421
                     /gene="ask"
                     /locus_tag="Rv3709c"
                     /coded_by="complement(NC_000962.2:4152218..4153483)"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="catalyzes the formation of 4-phospho-L-aspartate
                     from L-aspartate and ATP, in Bacillus, lysine sensitive;
                     regulated by response to starvation."
                     /transl_table=11
                     /db_xref="GeneID:885223"
ORIGIN      
        1 malvvqkygg ssvadaerir rvaerivatk kqgndvvvvv samgdttddl ldlaqqvcpa
       61 pppreldmll tagerisnal vamaieslga harsftgsqa gvittgthgn akiidvtpgr
      121 lqtaleegrv vlvagfqgvs qdtkdvttlg rggsdttava maaalgadvc eiytdvdgif
      181 sadprivrna rkldtvtfee mlemaacgak vlmlrcveya rrhnipvhvr ssysdrpgtv
      241 vvgsikdvpm edpiltgvah drseakvtiv glpdipgyaa kvfravadad vnidmvlqnv
      301 skvedgktdi tftcsrdvgp aavekldslr neigfsqlly ddhigkvsli gagmrshpgv
      361 tatfcealaa vgvnielist seirisvlcr dteldkavva lheafglggd eeatvyagtg
      421 r
//