LOCUS       NP_216908                254 aa            linear   BCT 19-NOV-2008
DEFINITION  phosphoadenosine phosphosulfate reductase [Mycobacterium
            tuberculosis H37Rv].
ACCESSION   NP_216908
VERSION     NP_216908.1  GI:15609529
DBSOURCE    REFSEQ: accession NC_000962.2
KEYWORDS    complete genome.
SOURCE      Mycobacterium tuberculosis H37Rv
  ORGANISM  Mycobacterium tuberculosis H37Rv
            Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
            Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium
            tuberculosis complex.
REFERENCE   1
  AUTHORS   Camus,J.C., Pryor,M.J., Medigue,C. and Cole,S.T.
  TITLE     Re-annotation of the genome sequence of Mycobacterium tuberculosis
            H37Rv
  JOURNAL   Microbiology (Reading, Engl.) 148 (Pt 10), 2967-2973 (2002)
   PUBMED   12368430
REFERENCE   2  (residues 1 to 254)
  AUTHORS   Cole,S.T., Brosch,R., Parkhill,J., Garnier,T., Churcher,C.,
            Harris,D., Gordon,S.V., Eiglmeier,K., Gas,S., Barry,C.E. III,
            Tekaia,F., Badcock,K., Basham,D., Brown,D., Chillingworth,T.,
            Connor,R., Davies,R., Devlin,K., Feltwell,T., Gentles,S.,
            Hamlin,N., Holroyd,S., Hornsby,T., Jagels,K., Krogh,A., McLean,J.,
            Moule,S., Murphy,L., Oliver,K., Osborne,J., Quail,M.A.,
            Rajandream,M.A., Rogers,J., Rutter,S., Seeger,K., Skelton,J.,
            Squares,R., Squares,S., Sulston,J.E., Taylor,K., Whitehead,S. and
            Barrell,B.G.
  TITLE     Deciphering the biology of Mycobacterium tuberculosis from the
            complete genome sequence
  JOURNAL   Nature 393 (6685), 537-544 (1998)
   PUBMED   9634230
  REMARK    Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE   3  (residues 1 to 254)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (13-SEP-2001) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CAB03733.
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..254
                     /organism="Mycobacterium tuberculosis H37Rv"
                     /strain="H37Rv"
                     /db_xref="taxon:83332"
     Protein         1..254
                     /product="phosphoadenosine phosphosulfate reductase"
                     /EC_number="1.8.4.8"
                     /function="INVOLVED IN THE SULFATE ACTIVATION PATHWAY (AT
                     THE THIRD STEP) IN THE REDUCTIVE BRANCH OF THE CYSTEINE
                     BIOSYNTHETIC PATHWAY. REDUCES ACTIVATED SULFATE INTO
                     SULFITE [CATALYTIC ACTIVITY: 5-PHOSPHOADENOSINE
                     3-PHOSPHOSULFATE + REDUCED THIOREDOXIN = PHOSPHOADENOSINE
                     PHOSPHATE + OXIDIZED THIOREDOXIN + SULFITE]."
                     /calculated_mol_wt=27292
     CDS             1..254
                     /gene="cysH"
                     /locus_tag="Rv2392"
                     /coded_by="NC_000962.2:2686367..2687131"
                     /note="catalyzes the reduction of 3'-phosphoadenylyl
                     sulfate into sulfite"
                     /transl_table=11
                     /db_xref="GOA:P65668"
                     /db_xref="UniProtKB/Swiss-Prot:P65668"
                     /db_xref="GeneID:885250"
ORIGIN      
        1 msgettrlte pqlrelaarg aaeldgatat dmlrwtdetf gdiggagggv sghrgwttcn
       61 yvvasnmada vlvdlaakvr pgvpvifldt gyhfvetigt rdaiesvydv rvlnvtpeht
      121 vaeqdellgk dlfarnphec crlrkvvplg ktlrgysawv tglrrvdapt ranaplvsfd
      181 etfklvkvnp laawtdqdvq eyiadndvlv nplvregyps igcapctakp aegadprsgr
      241 wqglaktecg lhas
//