LOCUS       NP_216848                548 aa            linear   BCT 19-NOV-2008
DEFINITION  malate dehydrogenase [Mycobacterium tuberculosis H37Rv].
ACCESSION   NP_216848
VERSION     NP_216848.2  GI:57116971
DBSOURCE    REFSEQ: accession NC_000962.2
KEYWORDS    complete genome.
SOURCE      Mycobacterium tuberculosis H37Rv
  ORGANISM  Mycobacterium tuberculosis H37Rv
            Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
            Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium
            tuberculosis complex.
REFERENCE   1
  AUTHORS   Camus,J.C., Pryor,M.J., Medigue,C. and Cole,S.T.
  TITLE     Re-annotation of the genome sequence of Mycobacterium tuberculosis
            H37Rv
  JOURNAL   Microbiology (Reading, Engl.) 148 (Pt 10), 2967-2973 (2002)
   PUBMED   12368430
REFERENCE   2  (residues 1 to 548)
  AUTHORS   Cole,S.T., Brosch,R., Parkhill,J., Garnier,T., Churcher,C.,
            Harris,D., Gordon,S.V., Eiglmeier,K., Gas,S., Barry,C.E. III,
            Tekaia,F., Badcock,K., Basham,D., Brown,D., Chillingworth,T.,
            Connor,R., Davies,R., Devlin,K., Feltwell,T., Gentles,S.,
            Hamlin,N., Holroyd,S., Hornsby,T., Jagels,K., Krogh,A., McLean,J.,
            Moule,S., Murphy,L., Oliver,K., Osborne,J., Quail,M.A.,
            Rajandream,M.A., Rogers,J., Rutter,S., Seeger,K., Skelton,J.,
            Squares,R., Squares,S., Sulston,J.E., Taylor,K., Whitehead,S. and
            Barrell,B.G.
  TITLE     Deciphering the biology of Mycobacterium tuberculosis from the
            complete genome sequence
  JOURNAL   Nature 393 (6685), 537-544 (1998)
   PUBMED   9634230
  REMARK    Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE   3  (residues 1 to 548)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (13-SEP-2001) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CAB02059.
            On Jan 5, 2005 this sequence version replaced gi:15609469.
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..548
                     /organism="Mycobacterium tuberculosis H37Rv"
                     /strain="H37Rv"
                     /db_xref="taxon:83332"
     Protein         1..548
                     /product="malate dehydrogenase"
                     /EC_number="1.1.1.38"
                     /function="CATALIZES THE OXIDATIVE DECARBOXYLATION OF
                     MALATE INTO PYRUVATE, IMPORTANT FOR A WIDE RANGE OF
                     METABOLIC PATHWAYS [CATALYTIC ACTIVITY: (S)-MALATE +
                     NAD(+) = PYRUVATE + CO(2) + NADH]."
                     /calculated_mol_wt=59292
     CDS             1..548
                     /gene="mez"
                     /locus_tag="Rv2332"
                     /coded_by="NC_000962.2:2605108..2606754"
                     /note="malic enzyme; oxaloacetate-decarboxylating;
                     NAD-dependent; catalyzes the formation of pyruvate form
                     malate"
                     /transl_table=11
                     /db_xref="GOA:P71880"
                     /db_xref="UniProtKB/Swiss-Prot:P71880"
                     /db_xref="GeneID:887962"
ORIGIN      
        1 msdarvprip aalsapslnr gvgfthaqrr rlgltgrlps avltldqqae rvwhqlqsla
       61 telgrnllle qlhyrhevly fkvladhlpe lmpvvytptv geaiqrfsde yrgqrglfls
      121 idepdeieea fntlglgped vdlivctdae ailgigdwgv ggiqiavgkl alytagggvd
      181 prrclavsld vgtdneqlla dpfylgnrha rrrgreydef vsryietaqr lfprailhfe
      241 dfgpanarki ldtygtdycv fnddmqgtga vvlaavysgl kvtgiplrdq tivvfgagta
      301 gmgiadqird amvadgatle qavsqiwpid rpgllfddmd dlrdfqvpya knrhqlgvav
      361 gdrvglsdai kiasptillg cstvygaftk evveamtasc khpmifplsn ptsrmeaipa
      421 dvlawsngra llatgspvap vefdettyvi gqannvlafp giglgvivag arlitrrmlh
      481 aaakaiahqa nptnpgdsll pdvqnlrais ttvaeavyra avqdgvasrt hddvrqaivd
      541 tmwlpayd
//