LOCUS       NP_216586                244 aa            linear   BCT 19-NOV-2008
DEFINITION  cobalt-precorrin-6x reductase [Mycobacterium tuberculosis H37Rv].
ACCESSION   NP_216586
VERSION     NP_216586.1  GI:15609207
DBSOURCE    REFSEQ: accession NC_000962.2
KEYWORDS    complete genome.
SOURCE      Mycobacterium tuberculosis H37Rv
  ORGANISM  Mycobacterium tuberculosis H37Rv
            Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
            Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium
            tuberculosis complex.
REFERENCE   1
  AUTHORS   Camus,J.C., Pryor,M.J., Medigue,C. and Cole,S.T.
  TITLE     Re-annotation of the genome sequence of Mycobacterium tuberculosis
            H37Rv
  JOURNAL   Microbiology (Reading, Engl.) 148 (Pt 10), 2967-2973 (2002)
   PUBMED   12368430
REFERENCE   2  (residues 1 to 244)
  AUTHORS   Cole,S.T., Brosch,R., Parkhill,J., Garnier,T., Churcher,C.,
            Harris,D., Gordon,S.V., Eiglmeier,K., Gas,S., Barry,C.E. III,
            Tekaia,F., Badcock,K., Basham,D., Brown,D., Chillingworth,T.,
            Connor,R., Davies,R., Devlin,K., Feltwell,T., Gentles,S.,
            Hamlin,N., Holroyd,S., Hornsby,T., Jagels,K., Krogh,A., McLean,J.,
            Moule,S., Murphy,L., Oliver,K., Osborne,J., Quail,M.A.,
            Rajandream,M.A., Rogers,J., Rutter,S., Seeger,K., Skelton,J.,
            Squares,R., Squares,S., Sulston,J.E., Taylor,K., Whitehead,S. and
            Barrell,B.G.
  TITLE     Deciphering the biology of Mycobacterium tuberculosis from the
            complete genome sequence
  JOURNAL   Nature 393 (6685), 537-544 (1998)
   PUBMED   9634230
  REMARK    Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE   3  (residues 1 to 244)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (13-SEP-2001) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CAA98217.
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..244
                     /organism="Mycobacterium tuberculosis H37Rv"
                     /strain="H37Rv"
                     /db_xref="taxon:83332"
     Protein         1..244
                     /product="cobalt-precorrin-6x reductase"
                     /EC_number="1.3.1.54"
                     /function="INVOLVED IN COBALAMIN BIOSYNTHESIS."
                     /calculated_mol_wt=25606
     CDS             1..244
                     /gene="cobK"
                     /locus_tag="Rv2070c"
                     /gene_synonym="cbiJ"
                     /coded_by="complement(NC_000962.2:2327491..2328225)"
                     /note="CobK/CbiJ; there are 2 pathways for cobalamin
                     (vitamin B12) production, one aerobic (ex. P.
                     denitrificans), the other anaerobic (ex. S. typhimurium);
                     the CobK/CbiJ perform similar reactions in both; the
                     anaerobic pathway includes the use of a chelated cobalt
                     ion in order for ring contraction to occur; CobK thus
                     converts precorrin 6 into dihydro-precorrin 6 while CbiJ
                     converts cobalt-precorrin 6 into cobalt-deihydro-precorrin
                     6"
                     /transl_table=11
                     /db_xref="GeneID:887566"
ORIGIN      
        1 mtrvlllggt aegralakel hphveivssl agrvpnpalp igpvriggfg gveglrgwlr
       61 eeridavvda thpfavtita haaqvcgelg lpylvlarpp wdpgtaiiav sdieaadvva
      121 eqgysrvflt tgrsgiaafa nsdawflirv vtapdgtalp rrhklvlsrg pygyhdefal
      181 lreqridalv tknsggkmtr akldaaaalg isvvmiarpl lpagvaavds vhraamwvag
      241 lpsr
//