LOCUS       NP_216068                583 aa            linear   BCT 19-NOV-2008
DEFINITION  fumarate reductase flavoprotein subunit [Mycobacterium tuberculosis
            H37Rv].
ACCESSION   NP_216068
VERSION     NP_216068.1  GI:15608690
DBSOURCE    REFSEQ: accession NC_000962.2
KEYWORDS    complete genome.
SOURCE      Mycobacterium tuberculosis H37Rv
  ORGANISM  Mycobacterium tuberculosis H37Rv
            Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
            Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium
            tuberculosis complex.
REFERENCE   1
  AUTHORS   Camus,J.C., Pryor,M.J., Medigue,C. and Cole,S.T.
  TITLE     Re-annotation of the genome sequence of Mycobacterium tuberculosis
            H37Rv
  JOURNAL   Microbiology (Reading, Engl.) 148 (Pt 10), 2967-2973 (2002)
   PUBMED   12368430
REFERENCE   2  (residues 1 to 583)
  AUTHORS   Cole,S.T., Brosch,R., Parkhill,J., Garnier,T., Churcher,C.,
            Harris,D., Gordon,S.V., Eiglmeier,K., Gas,S., Barry,C.E. III,
            Tekaia,F., Badcock,K., Basham,D., Brown,D., Chillingworth,T.,
            Connor,R., Davies,R., Devlin,K., Feltwell,T., Gentles,S.,
            Hamlin,N., Holroyd,S., Hornsby,T., Jagels,K., Krogh,A., McLean,J.,
            Moule,S., Murphy,L., Oliver,K., Osborne,J., Quail,M.A.,
            Rajandream,M.A., Rogers,J., Rutter,S., Seeger,K., Skelton,J.,
            Squares,R., Squares,S., Sulston,J.E., Taylor,K., Whitehead,S. and
            Barrell,B.G.
  TITLE     Deciphering the biology of Mycobacterium tuberculosis from the
            complete genome sequence
  JOURNAL   Nature 393 (6685), 537-544 (1998)
   PUBMED   9634230
  REMARK    Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE   3  (residues 1 to 583)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (13-SEP-2001) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CAA98311.
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..583
                     /organism="Mycobacterium tuberculosis H37Rv"
                     /strain="H37Rv"
                     /db_xref="taxon:83332"
     Protein         1..583
                     /product="fumarate reductase flavoprotein subunit"
                     /EC_number="1.3.99.1"
                     /function="INVOLVED IN INTERCONVERSION OF FUMARATE AND
                     SUCCINATE (ANAEROBIC RESPIRATION) [CATALYTIC ACTIVITY :
                     SUCCINATE + ACCEPTOR = FUMARATE + REDUCED ACCEPTOR]."
                     /calculated_mol_wt=63632
     CDS             1..583
                     /gene="frdA"
                     /locus_tag="Rv1552"
                     /coded_by="NC_000962.2:1757681..1759432"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="part of four member fumarate reductase enzyme
                     complex FrdABCD which catalyzes the reduction of fumarate
                     to succinate during anaerobic respiration; FrdAB are the
                     catalytic subcomplex consisting of a flavoprotein subunit
                     and an iron-sulfur subunit, respectively; FrdCD are the
                     membrane components which interact with quinone and are
                     involved in electron transfer; the catalytic subunits are
                     similar to succinate dehydrogenase SdhAB"
                     /transl_table=11
                     /db_xref="GOA:P64174"
                     /db_xref="UniProtKB/Swiss-Prot:P64174"
                     /db_xref="GeneID:886376"
ORIGIN      
        1 mtaqhnivvi ggggaglraa iaiaetnphl dvaivskvyp mrshtvsaeg gaaavtgddd
       61 sldehahdtv sggdwlcdqd aveafvaeap kelvqlehwg cpwsrkpdgr vavrpfggmk
      121 klrtwfaadk tgfhllhtlf qrlltysdvm rydewfattl lvddgrvcgl vaielatgri
      181 etiladavil ctggcgrvfp fttnaniktg dgmalafrag aplkdmefvq yhptglpftg
      241 iliteaarae ggwllnkdgy rylqdydlgk ptpeprlrsm elgprdrlsq afvhehnkgr
      301 tvdtpygpvv yldlrhlgad lidaklpfvr elcrdyqhid pvvelvpvrp vvhymmggvh
      361 tdingattlp glyaagetac vsinganrlg snslpellvf garagraaad yaarhqksdr
      421 gpssavraqa rtealrlere lsrhgqgger iadiradmqa tlesaagiyr dgptltkave
      481 eirvlqerfa tagiddhsrt fnteltalle lsgmldvala ivesglrree srgahqrtdf
      541 pnrddehfla htlvhresdg tlrvgylpvt itrwppgerv ygr
//