LOCUS NP_143026 244 aa linear PRI 18-NOV-2008
DEFINITION tumor necrosis factor ligand superfamily, member 11 isoform 2 [Homo
sapiens].
ACCESSION NP_143026
VERSION NP_143026.1 GI:14790152
DBSOURCE REFSEQ: accession NM_033012.3
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 244)
AUTHORS Tunyogi-Csapo,M., Kis-Toth,K., Radacs,M., Farkas,B., Jacobs,J.J.,
Finnegan,A., Mikecz,K. and Glant,T.T.
TITLE Cytokine-controlled RANKL and osteoprotegerin expression by human
and mouse synovial fibroblasts: fibroblast-mediated pathologic bone
resorption
JOURNAL Arthritis Rheum. 58 (8), 2397-2408 (2008)
PUBMED 18668542
REMARK GeneRIF: Synovial fibroblasts may significantly contribute to bone
resorption through modulation of RANKL and OPG production in a
cytokine-rich milieu of inflamed joints.
REFERENCE 2 (residues 1 to 244)
AUTHORS Menezes,R., Garlet,T.P., Letra,A., Bramante,C.M., Campanelli,A.P.,
Figueira Rde,C., Sogayar,M.C., Granjeiro,J.M. and Garlet,G.P.
TITLE Differential patterns of receptor activator of nuclear factor kappa
B ligand/osteoprotegerin expression in human periapical granulomas:
possible association with progressive or stable nature of the
lesions
JOURNAL J Endod 34 (8), 932-938 (2008)
PUBMED 18634923
REMARK GeneRIF: mRNA expression was higher in periapical granulomas when
compared with healthy periodontal ligament
REFERENCE 3 (residues 1 to 244)
AUTHORS Barbaroux,J.B., Beleut,M., Brisken,C., Mueller,C.G. and Groves,R.W.
TITLE Epidermal receptor activator of NF-kappaB ligand controls
Langerhans cells numbers and proliferation
JOURNAL J. Immunol. 181 (2), 1103-1108 (2008)
PUBMED 18606662
REMARK GeneRIF: These data indicate a key role for the RANKL system in the
regulation of Langerhans cells (LC) survival within the skin and
suggest a regulatory role for keratinocytes in the maintenance of
epidermal LC homeostasis
REFERENCE 4 (residues 1 to 244)
AUTHORS Belibasakis,G.N., Brage,M., Lagergard,T. and Johansson,A.
TITLE Cytolethal distending toxin upregulates RANKL expression in Jurkat
T-cells
JOURNAL APMIS 116 (6), 499-506 (2008)
PUBMED 18754324
REMARK GeneRIF: Cytolethal distending toxin enhances RANKL expression in
T-cells, denoting that these cells are a potential target for the
toxin and strengthening the potential link between this virulence
factor and mechanisms associated with localized bone resorption.
REFERENCE 5 (residues 1 to 244)
AUTHORS Kwan Tat,S., Pelletier,J.P., Lajeunesse,D., Fahmi,H., Lavigne,M.
and Martel-Pelletier,J.
TITLE The differential expression of osteoprotegerin (OPG) and receptor
activator of nuclear factor kappaB ligand (RANKL) in human
osteoarthritic subchondral bone osteoblasts is an indicator of the
metabolic state of these disease cells
JOURNAL Clin. Exp. Rheumatol. 26 (2), 295-304 (2008)
PUBMED 18565252
REMARK GeneRIF: OPG and RANKL levels, and consequently the OPG/RANKL
ratio, differed according to human osteoarthritis subchondral bone
osteoblast classification
REFERENCE 6 (residues 1 to 244)
AUTHORS Lacey,D.L., Timms,E., Tan,H.L., Kelley,M.J., Dunstan,C.R.,
Burgess,T., Elliott,R., Colombero,A., Elliott,G., Scully,S.,
Hsu,H., Sullivan,J., Hawkins,N., Davy,E., Capparelli,C., Eli,A.,
Qian,Y.X., Kaufman,S., Sarosi,I., Shalhoub,V., Senaldi,G., Guo,J.,
Delaney,J. and Boyle,W.J.
TITLE Osteoprotegerin ligand is a cytokine that regulates osteoclast
differentiation and activation
JOURNAL Cell 93 (2), 165-176 (1998)
PUBMED 9568710
REFERENCE 7 (residues 1 to 244)
AUTHORS Yasuda,H., Shima,N., Nakagawa,N., Yamaguchi,K., Kinosaki,M.,
Mochizuki,S., Tomoyasu,A., Yano,K., Goto,M., Murakami,A., Tsuda,E.,
Morinaga,T., Higashio,K., Udagawa,N., Takahashi,N. and Suda,T.
TITLE Osteoclast differentiation factor is a ligand for
osteoprotegerin/osteoclastogenesis-inhibitory factor and is
identical to TRANCE/RANKL
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 95 (7), 3597-3602 (1998)
PUBMED 9520411
REFERENCE 8 (residues 1 to 244)
AUTHORS Wong,B.R., Josien,R., Lee,S.Y., Sauter,B., Li,H.L., Steinman,R.M.
and Choi,Y.
TITLE TRANCE (tumor necrosis factor [TNF]-related activation-induced
cytokine), a new TNF family member predominantly expressed in T
cells, is a dendritic cell-specific survival factor
JOURNAL J. Exp. Med. 186 (12), 2075-2080 (1997)
PUBMED 9396779
REFERENCE 9 (residues 1 to 244)
AUTHORS Anderson,D.M., Maraskovsky,E., Billingsley,W.L., Dougall,W.C.,
Tometsko,M.E., Roux,E.R., Teepe,M.C., DuBose,R.F., Cosman,D. and
Galibert,L.
TITLE A homologue of the TNF receptor and its ligand enhance T-cell
growth and dendritic-cell function
JOURNAL Nature 390 (6656), 175-179 (1997)
PUBMED 9367155
REFERENCE 10 (residues 1 to 244)
AUTHORS Wong,B.R., Rho,J., Arron,J., Robinson,E., Orlinick,J., Chao,M.,
Kalachikov,S., Cayani,E., Bartlett,F.S. III, Frankel,W.N., Lee,S.Y.
and Choi,Y.
TITLE TRANCE is a novel ligand of the tumor necrosis factor receptor
family that activates c-Jun N-terminal kinase in T cells
JOURNAL J. Biol. Chem. 272 (40), 25190-25194 (1997)
PUBMED 9312132
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC040889.1, AL139382.12 and
BQ007726.1.
Summary: This gene encodes a member of the tumor necrosis factor
(TNF) cytokine family which is a ligand for osteoprotegerin and
functions as a key factor for osteoclast differentiation and
activation. This protein was shown to be a dentritic cell survival
factor and is involved in the regulation of T cell-dependent immune
response. T cell activation was reported to induce expression of
this gene and lead to an increase of osteoclastogenesis and bone
loss. This protein was shown to activate antiapoptotic kinase
AKT/PKB through a signaling complex involving SRC kinase and tumor
necrosis factor receptor-associated factor (TRAF) 6, which
indicated this protein may have a role in the regulation of cell
apoptosis. Targeted disruption of the related gene in mice led to
severe osteopetrosis and a lack of osteoclasts. The deficient mice
exhibited defects in early differentiation of T and B lymphocytes,
and failed to form lobulo-alveolar mammary structures during
pregnancy. Two alternatively spliced transcript variants have been
found. [provided by RefSeq].
Transcript Variant: This variant (2) differs in the 5' UTR and
coding region, compared to variant 1. These differences cause
translation initiation at a downstream AUG and an isoform (2) with
a shorter N-terminus compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..244
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="13"
/map="13q14"
Protein 1..244
/product="tumor necrosis factor ligand superfamily, member
11 isoform 2"
/note="TNF-related activation-induced cytokine; receptor
activator of nuclear factor kappa B ligand;
osteoprotegerin ligand; osteoclast differentiation factor"
/calculated_mol_wt=27559
CDS 1..244
/gene="TNFSF11"
/gene_synonym="ODF"
/gene_synonym="OPGL"
/gene_synonym="sOdf"
/gene_synonym="CD254"
/gene_synonym="OPTB2"
/gene_synonym="RANKL"
/gene_synonym="TRANCE"
/gene_synonym="hRANKL2"
/coded_by="NM_033012.3:530..1264"
/note="isoform 2 is encoded by transcript variant 2"
/db_xref="CCDS:CCDS9385.1"
/db_xref="GeneID:8600"
/db_xref="HGNC:11926"
/db_xref="HPRD:04031"
/db_xref="MIM:602642"
ORIGIN
1 mdpnrisedg thciyrilrl henadfqdtt lesqdtklip dscrrikqaf qgavqkelqh
61 ivgsqhirae kamvdgswld lakrskleaq pfahltinat dipsgshkvs lsswyhdrgw
121 akisnmtfsn gklivnqdgf yylyanicfr hhetsgdlat eylqlmvyvt ktsikipssh
181 tlmkggstky wsgnsefhfy sinvggffkl rsgeeisiev snpslldpdq datyfgafkv
241 rdid
//