LOCUS NP_036630 316 aa linear ROD 24-OCT-2008
DEFINITION aldehyde reductase 1 [Rattus norvegicus].
ACCESSION NP_036630
VERSION NP_036630.1 GI:6978491
DBSOURCE REFSEQ: accession NM_012498.1
KEYWORDS .
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (residues 1 to 316)
AUTHORS Jang,D.S., Lee,G.Y., Kim,Y.S., Lee,Y.M., Kim,C.S., Yoo,J.L. and
Kim,J.S.
TITLE Anthraquinones from the seeds of Cassia tora with inhibitory
activity on protein glycation and aldose reductase
JOURNAL Biol. Pharm. Bull. 30 (11), 2207-2210 (2007)
PUBMED 17978503
REMARK GeneRIF: Several anthraquinones isolated from Cassia inhibited Alr
of the crystalline lens.
REFERENCE 2 (residues 1 to 316)
AUTHORS Ramana,K.V., Bhatnagar,A., Srivastava,S., Yadav,U.C., Awasthi,S.,
Awasthi,Y.C. and Srivastava,S.K.
TITLE Mitogenic responses of vascular smooth muscle cells to lipid
peroxidation-derived aldehyde 4-hydroxy-trans-2-nonenal (HNE): role
of aldose reductase-catalyzed reduction of the HNE-glutathione
conjugates in regulating cell growth
JOURNAL J. Biol. Chem. 281 (26), 17652-17660 (2006)
PUBMED 16648138
REFERENCE 3 (residues 1 to 316)
AUTHORS Kaiserova,K., Srivastava,S., Hoetker,J.D., Awe,S.O., Tang,X.L.,
Cai,J. and Bhatnagar,A.
TITLE Redox activation of aldose reductase in the ischemic heart
JOURNAL J. Biol. Chem. 281 (22), 15110-15120 (2006)
PUBMED 16567803
REFERENCE 4 (residues 1 to 316)
AUTHORS Jiang,T., Che,Q., Lin,Y., Li,H. and Zhang,N.
TITLE Aldose reductase regulates TGF-beta1-induced production of
fibronectin and type IV collagen in cultured rat mesangial cells
JOURNAL Nephrology (Carlton) 11 (2), 105-112 (2006)
PUBMED 16669970
REFERENCE 5 (residues 1 to 316)
AUTHORS Srivastava,S., Ramana,K.V., Tammali,R., Srivastava,S.K. and
Bhatnagar,A.
TITLE Contribution of aldose reductase to diabetic hyperproliferation of
vascular smooth muscle cells
JOURNAL Diabetes 55 (4), 901-910 (2006)
PUBMED 16567509
REMARK GeneRIF: Aldose reductase prevents glucose-induced stimulation of
vascular smooth muscle cell growth in culture and in situ.
REFERENCE 6 (residues 1 to 316)
AUTHORS Laeng,P., Bouillon,P., Taupenot,L. and Labourdette,G.
TITLE Long-term induction of an aldose reductase protein by basic
fibroblast growth factor in rat astrocytes in vitro
JOURNAL Electrophoresis 16 (7), 1240-1250 (1995)
PUBMED 7498172
REFERENCE 7 (residues 1 to 316)
AUTHORS Graham,C., Szpirer,C., Levan,G. and Carper,D.
TITLE Characterization of the aldose reductase-encoding gene family in
rat
JOURNAL Gene 107 (2), 259-267 (1991)
PUBMED 1748296
REFERENCE 8 (residues 1 to 316)
AUTHORS Old,S.E., Sato,S., Kador,P.F. and Carper,D.A.
TITLE In vitro expression of rat lens aldose reductase in Escherichia
coli
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (13), 4942-4945 (1990)
PUBMED 2114645
REFERENCE 9 (residues 1 to 316)
AUTHORS Carper,D., Nishimura,C., Shinohara,T., Dietzchold,B., Wistow,G.,
Craft,C., Kador,P. and Kinoshita,J.H.
TITLE Aldose reductase and p-crystallin belong to the same protein
superfamily as aldehyde reductase
JOURNAL FEBS Lett. 220 (1), 209-213 (1987)
PUBMED 3111886
REFERENCE 10 (residues 1 to 316)
AUTHORS Malone,J.I., Leavengood,H., Peterson,M.J., O'Brien,M.M., Page,M.G.
and Aldinger,C.E.
TITLE Red blood cell sorbitol as an indicator of polyol pathway activity.
Inhibition by sorbinil in insulin-dependent diabetic subjects
JOURNAL Diabetes 33 (1), 45-49 (1984)
PUBMED 6690344
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from M60322.1.
Summary: regulates NF-kappa B mediated mitogenic signaling; may
play a role in the polyol pathway [RGD].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..316
/organism="Rattus norvegicus"
/strain="Sprague-Dawley"
/db_xref="taxon:10116"
/chromosome="4"
/map="4q22"
Protein 1..316
/product="aldehyde reductase 1"
/EC_number="1.1.1.21"
/note="Aldehyde reductase 1 (low Km aldose reductase) (5.8
kb PstI fragment, probably the functional gene); aldo-keto
reductase family 1, member B4 (aldose reductase)"
/calculated_mol_wt=35666
CDS 1..316
/gene="Akr1b1"
/gene_synonym="Alr"
/gene_synonym="Aldr1"
/gene_synonym="ALDRED"
/gene_synonym="Akr1b3"
/gene_synonym="Akr1b4"
/gene_synonym="ALR-P-I"
/gene_synonym="RATALDRED"
/coded_by="NM_012498.1:39..989"
/db_xref="GeneID:24192"
/db_xref="RATMAP:56"
/db_xref="RGD:2092"
ORIGIN
1 mashlelnng tkmptlglgt wksppgqvte avkvaidmgy rhidcaqvyq nekevgvalq
61 eklkeqvvkr qdlfivsklw ctfhdqsmvk gacqktlsdl qldyldlyli hwptgfkpgp
121 dyfpldasgn vipsdtdfvd twtameqlvd eglvkaigvs nfnplqieri lnkpglkykp
181 avnqiechpy ltqeklieyc hckgivvtay splgspdrpw akpedpslle dprikeiaak
241 ynkttaqvli rfpiqrnlvv ipksvtpari aenfkvfdfe lsnedmatll synrnwrvca
301 lmscakhkdy pfhaev
//