LOCUS NP_006283 390 aa linear PRI 28-SEP-2008
DEFINITION tumor susceptibility gene 101 [Homo sapiens].
ACCESSION NP_006283
VERSION NP_006283.1 GI:5454140
DBSOURCE REFSEQ: accession NM_006292.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 390)
AUTHORS Hosgood,H.D. III, Menashe,I., Shen,M., Yeager,M., Yuenger,J.,
Rajaraman,P., He,X., Chatterjee,N., Caporaso,N., Zhu,Y.,
Chanock,S., Zheng,T. and Lan,Q.
TITLE Pathway-based evaluation of 380 candidate genes and lung cancer
susceptibility suggests the importance of the cell cycle pathway
JOURNAL Carcinogenesis (2008) In press
PUBMED 18676680
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
Publication Status: Available-Online prior to print
REFERENCE 2 (residues 1 to 390)
AUTHORS Barbe,L., Lundberg,E., Oksvold,P., Stenius,A., Lewin,E.,
Bjorling,E., Asplund,A., Ponten,F., Brismar,H., Uhlen,M. and
Andersson-Svahn,H.
TITLE Toward a confocal subcellular atlas of the human proteome
JOURNAL Mol. Cell Proteomics 7 (3), 499-508 (2008)
PUBMED 18029348
REFERENCE 3 (residues 1 to 390)
AUTHORS Yanagida-Ishizaki,Y., Takei,T., Ishizaki,R., Imakagura,H.,
Takahashi,S., Shin,H.W., Katoh,Y. and Nakayama,K.
TITLE Recruitment of Tom1L1/Srcasm to endosomes and the midbody by Tsg101
JOURNAL Cell Struct. Funct. 33 (1), 91-100 (2008)
PUBMED 18367816
REMARK GeneRIF: study found that not only the PTAP sequence in the GAT
domain but also the PSAP sequence in the C-terminal region of
Tom1L1 is responsible for its interaction with the UEV domain of
Tsg101 and competes with the HIV-1 Gag protein for the Tsg101
interaction
REFERENCE 4 (residues 1 to 390)
AUTHORS Silvestri,L.S., Ruthel,G., Kallstrom,G., Warfield,K.L.,
Swenson,D.L., Nelle,T., Iversen,P.L., Bavari,S. and Aman,M.J.
TITLE Involvement of vacuolar protein sorting pathway in Ebola virus
release independent of TSG101 interaction
JOURNAL J. Infect. Dis. 196 SUPPL 2, S264-S270 (2007)
PUBMED 17940959
REMARK GeneRIF: Ebola virus can use vacuolar protein surting proteins
independently of TSG101 for budding and reveal vacuolar sorting
protein 4 as a potential target for filovirus therapeutics.
REFERENCE 5 (residues 1 to 390)
AUTHORS Morita,E., Sandrin,V., Chung,H.Y., Morham,S.G., Gygi,S.P.,
Rodesch,C.K. and Sundquist,W.I.
TITLE Human ESCRT and ALIX proteins interact with proteins of the midbody
and function in cytokinesis
JOURNAL EMBO J. 26 (19), 4215-4227 (2007)
PUBMED 17853893
REMARK GeneRIF: that ALIX and TSG101/ESCRT-I also bind a series of
proteins involved in cytokinesis, including CEP55, CD2AP, ROCK1,
and IQGAP1.
REFERENCE 6 (residues 1 to 390)
AUTHORS Gayther,S.A., Barski,P., Batley,S.J., Li,L., de Foy,K.A.,
Cohen,S.N., Ponder,B.A. and Caldas,C.
TITLE Aberrant splicing of the TSG101 and FHIT genes occurs frequently in
multiple malignancies and in normal tissues and mimics alterations
previously described in tumours
JOURNAL Oncogene 15 (17), 2119-2126 (1997)
PUBMED 9366528
REFERENCE 7 (residues 1 to 390)
AUTHORS Lee,M.P. and Feinberg,A.P.
TITLE Aberrant splicing but not mutations of TSG101 in human breast
cancer
JOURNAL Cancer Res. 57 (15), 3131-3134 (1997)
PUBMED 9242438
REFERENCE 8 (residues 1 to 390)
AUTHORS Steiner,P., Barnes,D.M., Harris,W.H. and Weinberg,R.A.
TITLE Absence of rearrangements in the tumour susceptibility gene TSG101
in human breast cancer
JOURNAL Nat. Genet. 16 (4), 332-333 (1997)
PUBMED 9241265
REFERENCE 9 (residues 1 to 390)
AUTHORS Koonin,E.V. and Abagyan,R.A.
TITLE TSG101 may be the prototype of a class of dominant negative
ubiquitin regulators
JOURNAL Nat. Genet. 16 (4), 330-331 (1997)
PUBMED 9241264
REFERENCE 10 (residues 1 to 390)
AUTHORS Li,L., Li,X., Francke,U. and Cohen,S.N.
TITLE The TSG101 tumor susceptibility gene is located in chromosome 11
band p15 and is mutated in human breast cancer
JOURNAL Cell 88 (1), 143-154 (1997)
PUBMED 9019400
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from U82130.1, AU138453.1 and
BC002487.1.
Summary: The protein encoded by this gene belongs to a group of
apparently inactive homologs of ubiquitin-conjugating enzymes. The
gene product contains a coiled-coil domain that interacts with
stathmin, a cytosolic phosphoprotein implicated in tumorigenesis.
The protein may play a role in cell growth and differentiation and
act as a negative growth regulator. In vitro steady-state
expression of this tumor susceptibility gene appears to be
important for maintenance of genomic stability and cell cycle
regulation. Mutations and alternative splicing in this gene occur
in high frequency in breast cancer and suggest that defects occur
during breast cancer tumorigenesis and/or progression. [provided by
RefSeq].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..390
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="11"
/map="11p15"
Protein 1..390
/product="tumor susceptibility gene 101"
/note="tumor susceptibility protein"
/calculated_mol_wt=43813
CDS 1..390
/gene="TSG101"
/gene_synonym="TSG10"
/gene_synonym="VPS23"
/coded_by="NM_006292.2:127..1299"
/db_xref="CCDS:CCDS7842.1"
/db_xref="GeneID:7251"
/db_xref="HGNC:15971"
/db_xref="HPRD:03229"
/db_xref="MIM:601387"
ORIGIN
1 mavsesqlkk mvskykyrdl tvretvnvit lykdlkpvld syvfndgssr elmnltgtip
61 vpyrgntyni piclwlldty pynppicfvk ptssmtiktg khvdangkiy lpylhewkhp
121 qsdllgliqv mivvfgdepp vfsrpisasy ppyqatgppn tsympgmpgg ispypsgypp
181 npsgypgcpy ppggpypatt ssqypsqppv ttvgpsrdgt isedtirasl isavsdklrw
241 rmkeemdraq aelnalkrte edlkkghqkl eemvtrldqe vaevdkniel lkkkdeelss
301 alekmenqse nndideviip taplykqiln lyaeenaied tifylgealr rgvidldvfl
361 khvrllsrkq fqlralmqka rktaglsdly
//