LOCUS NP_005456 479 aa linear PRI 28-SEP-2008
DEFINITION v-akt murine thymoma viral oncogene homolog 3 isoform 1 [Homo
sapiens].
ACCESSION NP_005456
VERSION NP_005456.1 GI:4885549
DBSOURCE REFSEQ: accession NM_005465.3
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 479)
AUTHORS Cheung,M., Sharma,A., Madhunapantula,S.V. and Robertson,G.P.
TITLE Akt3 and mutant V600E B-Raf cooperate to promote early melanoma
development
JOURNAL Cancer Res. 68 (9), 3429-3439 (2008)
PUBMED 18451171
REMARK GeneRIF: Akt3 and mutant V600E B-Raf cooperate to promote early
melanoma development.
REFERENCE 2 (residues 1 to 479)
AUTHORS Pham,N.A., Tsao,M.S., Cao,P. and Hedley,D.W.
TITLE Dissociation of gemcitabine sensitivity and protein kinase B
signaling in pancreatic ductal adenocarcinoma models
JOURNAL Pancreas 35 (3), E16-E26 (2007)
PUBMED 17895832
REMARK GeneRIF: PKB[alpha] and/or PKB[gamma] and not PKB[beta] alone are
involved in gemcitabine resistance mechanisms.
REFERENCE 3 (residues 1 to 479)
AUTHORS Boland,E., Clayton-Smith,J., Woo,V.G., McKee,S., Manson,F.D.,
Medne,L., Zackai,E., Swanson,E.A., Fitzpatrick,D., Millen,K.J.,
Sherr,E.H., Dobyns,W.B. and Black,G.C.
TITLE Mapping of deletion and translocation breakpoints in 1q44
implicates the serine/threonine kinase AKT3 in postnatal
microcephaly and agenesis of the corpus callosum
JOURNAL Am. J. Hum. Genet. 81 (2), 292-303 (2007)
PUBMED 17668379
REMARK GeneRIF: AKT3 represents an excellent candidate for developmental
human MIC and ACC, and we suggest that haploinsufficiency causes
both postnatal MIC and ACC.
REFERENCE 4 (residues 1 to 479)
AUTHORS Cristiano,B.E., Chan,J.C., Hannan,K.M., Lundie,N.A.,
Marmy-Conus,N.J., Campbell,I.G., Phillips,W.A., Robbie,M.,
Hannan,R.D. and Pearson,R.B.
TITLE A specific role for AKT3 in the genesis of ovarian cancer through
modulation of G(2)-M phase transition
JOURNAL Cancer Res. 66 (24), 11718-11725 (2006)
PUBMED 17178867
REMARK GeneRIF: AKT3 is highly expressed in 19 of 92 primary ovarian
tumors, consistent with AKT3 playing a key role in the genesis of
at least one subset of ovarian cancers.
REFERENCE 5 (residues 1 to 479)
AUTHORS Cicenas,J., Urban,P., Vuaroqueaux,V., Labuhn,M., Kung,W., Wight,E.,
Mayhew,M., Eppenberger,U. and Eppenberger-Castori,S.
TITLE Increased level of phosphorylated akt measured by
chemiluminescence-linked immunosorbent assay is a predictor of poor
prognosis in primary breast cancer overexpressing ErbB-2
JOURNAL Breast Cancer Res. 7 (4), R394-R401 (2005)
PUBMED 15987444
REMARK GeneRIF: in breast cancer patients, Akt activation is associated
with tumour proliferation and poor prognosis, particularly in the
subset of patients with ErbB2-overexpressing tumours
REFERENCE 6 (sites)
AUTHORS Hodgkinson,C.P., Sale,E.M. and Sale,G.J.
TITLE Characterization of PDK2 activity against protein kinase B gamma
JOURNAL Biochemistry 41 (32), 10351-10359 (2002)
PUBMED 12162751
REFERENCE 7 (residues 1 to 479)
AUTHORS Nakatani,K., Sakaue,H., Thompson,D.A., Weigel,R.J. and Roth,R.A.
TITLE Identification of a human Akt3 (protein kinase B gamma) which
contains the regulatory serine phosphorylation site
JOURNAL Biochem. Biophys. Res. Commun. 257 (3), 906-910 (1999)
PUBMED 10208883
REFERENCE 8 (residues 1 to 479)
AUTHORS Brodbeck,D., Cron,P. and Hemmings,B.A.
TITLE A human protein kinase Bgamma with regulatory phosphorylation sites
in the activation loop and in the C-terminal hydrophobic domain
JOURNAL J. Biol. Chem. 274 (14), 9133-9136 (1999)
PUBMED 10092583
REFERENCE 9 (residues 1 to 479)
AUTHORS Walker,K.S., Deak,M., Paterson,A., Hudson,K., Cohen,P. and
Alessi,D.R.
TITLE Activation of protein kinase B beta and gamma isoforms by insulin
in vivo and by 3-phosphoinositide-dependent protein kinase-1 in
vitro: comparison with protein kinase B alpha
JOURNAL Biochem. J. 331 (PT 1), 299-308 (1998)
PUBMED 9512493
REFERENCE 10 (sites)
AUTHORS Walker,K.S., Deak,M., Paterson,A., Hudson,K., Cohen,P. and
Alessi,D.R.
TITLE Activation of protein kinase B beta and gamma isoforms by insulin
in vivo and by 3-phosphoinositide-dependent protein kinase-1 in
vitro: comparison with protein kinase B alpha
JOURNAL Biochem. J. 331 (PT 1), 299-308 (1998)
PUBMED 9512493
REFERENCE 11 (residues 1 to 479)
AUTHORS Borgatti,P., Zauli,G., Colamussi,M.L., Gibellini,D., Previati,M.,
Cantley,L.L. and Capitani,S.
TITLE Extracellular HIV-1 Tat protein activates phosphatidylinositol 3-
and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells
JOURNAL Eur. J. Immunol. 27 (11), 2805-2811 (1997)
PUBMED 9394803
REFERENCE 12 (residues 1 to 479)
AUTHORS Li,W., Zhang,J., Bottaro,D.P. and Pierce,J.H.
TITLE Identification of serine 643 of protein kinase C-delta as an
important autophosphorylation site for its enzymatic activity
JOURNAL J. Biol. Chem. 272 (39), 24550-24555 (1997)
PUBMED 9305920
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AF135794.1, AW960221.1 and
BG702262.1.
Summary: The protein encoded by this gene is a member of the AKT,
also called PKB, serine/threonine protein kinase family. AKT
kinases are known to be regulators of cell signaling in response to
insulin and growth factors. They are involved in a wide variety of
biological processes including cell proliferation, differentiation,
apoptosis, tumorigenesis, as well as glycogen synthesis and glucose
uptake. This kinase has been shown to be stimulated by
platelet-derived growth factor (PDGF), insulin, and insulin-like
growth factor 1 (IGF1). Alternatively splice transcript variants
encoding distinct isoforms have been described. [provided by
RefSeq].
Transcript Variant: This variant (1) encodes the longer isoform
(1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..479
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q43-q44"
Protein 1..479
/product="v-akt murine thymoma viral oncogene homolog 3
isoform 1"
/EC_number="2.7.1.37"
/note="protein kinase B gamma; RAC-gamma serine/threonine
protein kinase; serine threonine protein kinase, Akt-3"
/calculated_mol_wt=55644
Site 120
/site_type="phosphorylation"
/experiment="experimental evidence, no additional details
recorded"
/citation=[9]
/db_xref="HPRD:03954"
Site 305
/site_type="phosphorylation"
/experiment="experimental evidence, no additional details
recorded"
/citation=[6]
/citation=[9]
/db_xref="HPRD:01504"
Site 305
/site_type="phosphorylation"
/experiment="experimental evidence, no additional details
recorded"
/citation=[6]
/citation=[9]
/db_xref="HPRD:05556"
Site 472
/site_type="phosphorylation"
/experiment="experimental evidence, no additional details
recorded"
/citation=[6]
/db_xref="HPRD:01501"
CDS 1..479
/gene="AKT3"
/gene_synonym="PKBG"
/gene_synonym="PRKBG"
/gene_synonym="STK-2"
/gene_synonym="PKB-GAMMA"
/gene_synonym="RAC-gamma"
/gene_synonym="RAC-PK-gamma"
/gene_synonym="DKFZp434N0250"
/coded_by="NM_005465.3:82..1521"
/note="isoform 1 is encoded by transcript variant 1"
/db_xref="CCDS:CCDS31077.1"
/db_xref="GeneID:10000"
/db_xref="HGNC:393"
/db_xref="HPRD:06441"
/db_xref="MIM:611223"
ORIGIN
1 msdvtivkeg wvqkrgeyik nwrpryfllk tdgsfigyke kpqdvdlpyp lnnfsvakcq
61 lmkterpkpn tfiirclqwt tviertfhvd tpeereewte aiqavadrlq rqeeermncs
121 ptsqidnige eemdastthh krktmndfdy lkllgkgtfg kvilvrekas gkyyamkilk
181 keviiakdev ahtltesrvl kntrhpflts lkysfqtkdr lcfvmeyvng gelffhlsre
241 rvfsedrtrf ygaeivsald ylhsgkivyr dlklenlmld kdghikitdf glckegitda
301 atmktfcgtp eylapevled ndygravdww glgvvmyemm cgrlpfynqd heklfelilm
361 edikfprtls sdaksllsgl likdpnkrlg ggpddakeim rhsffsgvnw qdvydkklvp
421 pfkpqvtset dtryfdeeft aqtititppe kydedgmdcm dnerrphfpq fsysasgre
//