LOCUS NP_004926 292 aa linear PRI 24-OCT-2008
DEFINITION cyclin-dependent kinase 5 [Homo sapiens].
ACCESSION NP_004926
VERSION NP_004926.1 GI:4826675
DBSOURCE REFSEQ: accession NM_004935.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 292)
AUTHORS Hosgood,H.D. III, Menashe,I., Shen,M., Yeager,M., Yuenger,J.,
Rajaraman,P., He,X., Chatterjee,N., Caporaso,N.E., Zhu,Y.,
Chanock,S.J., Zheng,T. and Lan,Q.
TITLE Pathway-based evaluation of 380 candidate genes and lung cancer
susceptibility suggests the importance of the cell cycle pathway
JOURNAL Carcinogenesis 29 (10), 1938-1943 (2008)
PUBMED 18676680
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 2 (residues 1 to 292)
AUTHORS Lee,J.H., Jeong,M.W., Kim,W., Choi,Y.H. and Kim,K.T.
TITLE Cooperative roles of c-Abl and Cdk5 in regulation of p53 in
response to oxidative stress
JOURNAL J. Biol. Chem. 283 (28), 19826-19835 (2008)
PUBMED 18490454
REMARK GeneRIF: c-Abl and Cdk5 cooperatively regulate maximal activation
of p53, resulting in neuronal death in response to oxidative stress
by hydrogen peroxide.
REFERENCE 3 (residues 1 to 292)
AUTHORS Cole,A.R., Soutar,M.P., Rembutsu,M., van Aalten,L., Hastie,C.J.,
McLauchlan,H., Peggie,M., Balastik,M., Lu,K.P. and Sutherland,C.
TITLE Relative resistance of Cdk5-phosphorylated CRMP2 to
dephosphorylation
JOURNAL J. Biol. Chem. 283 (26), 18227-18237 (2008)
PUBMED 18460467
REMARK GeneRIF: relative resistance to phosphatases might be a common
feature of Cdk5 substrates and could contribute to the
hyperphosphorylation of CRMP2 and Tau observed in Alzheimer disease
REFERENCE 4 (residues 1 to 292)
AUTHORS Liu,R., Tian,B., Gearing,M., Hunter,S., Ye,K. and Mao,Z.
TITLE Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma
cell invasion
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 105 (21), 7570-7575 (2008)
PUBMED 18487454
REMARK GeneRIF: Cdk5 phosphorylates PIKE-A and stimulates its GTPase
activity, which activates nuclear Akt and promotes glioblastoma
cell migration and invasion.
REFERENCE 5 (residues 1 to 292)
AUTHORS Sanghera,D.K., Ortega,L., Han,S., Singh,J., Ralhan,S.K.,
Wander,G.S., Mehra,N.K., Mulvihill,J.J., Ferrell,R.E., Nath,S.K.
and Kamboh,M.I.
TITLE Impact of nine common type 2 diabetes risk polymorphisms in Asian
Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants
confer a significant risk
JOURNAL BMC Med. Genet. 9, 59 (2008)
PUBMED 18598350
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
Publication Status: Online-Only
REFERENCE 6 (sites)
AUTHORS Tanaka,T., Serneo,F.F., Tseng,H.C., Kulkarni,A.B., Tsai,L.H. and
Gleeson,J.G.
TITLE Cdk5 phosphorylation of doublecortin ser297 regulates its effect on
neuronal migration
JOURNAL Neuron 41 (2), 215-227 (2004)
PUBMED 14741103
REFERENCE 7 (sites)
AUTHORS Liu,F., Iqbal,K., Grundke-Iqbal,I. and Gong,C.X.
TITLE Involvement of aberrant glycosylation in phosphorylation of tau by
cdk5 and GSK-3beta
JOURNAL FEBS Lett. 530 (1-3), 209-214 (2002)
PUBMED 12387894
REFERENCE 8 (sites)
AUTHORS Sasaki,Y., Cheng,C., Uchida,Y., Nakajima,O., Ohshima,T., Yagi,T.,
Taniguchi,M., Nakayama,T., Kishida,R., Kudo,Y., Ohno,S.,
Nakamura,F. and Goshima,Y.
TITLE Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in
regulation of dendrite orientation in cerebral cortex
JOURNAL Neuron 35 (5), 907-920 (2002)
PUBMED 12372285
REFERENCE 9 (sites)
AUTHORS Zukerberg,L.R., Patrick,G.N., Nikolic,M., Humbert,S., Wu,C.L.,
Lanier,L.M., Gertler,F.B., Vidal,M., Van Etten,R.A. and Tsai,L.H.
TITLE Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine
phosphorylation, kinase upregulation, and neurite outgrowth
JOURNAL Neuron 26 (3), 633-646 (2000)
PUBMED 10896159
REFERENCE 10 (sites)
AUTHORS Sharma,P., Sharma,M., Amin,N.D., Albers,R.W. and Pant,H.C.
TITLE Regulation of cyclin-dependent kinase 5 catalytic activity by
phosphorylation
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 96 (20), 11156-11160 (1999)
PUBMED 10500146
REFERENCE 11 (sites)
AUTHORS Hanger,D.P., Betts,J.C., Loviny,T.L., Blackstock,W.P. and
Anderton,B.H.
TITLE New phosphorylation sites identified in hyperphosphorylated tau
(paired helical filament-tau) from Alzheimer's disease brain using
nanoelectrospray mass spectrometry
JOURNAL J. Neurochem. 71 (6), 2465-2476 (1998)
PUBMED 9832145
REFERENCE 12 (sites)
AUTHORS Wang,J.Z., Wu,Q., Smith,A., Grundke-Iqbal,I. and Iqbal,K.
TITLE Tau is phosphorylated by GSK-3 at several sites found in Alzheimer
disease and its biological activity markedly inhibited only after
it is prephosphorylated by A-kinase
JOURNAL FEBS Lett. 436 (1), 28-34 (1998)
PUBMED 9771888
REFERENCE 13 (sites)
AUTHORS Sengupta,A., Kabat,J., Novak,M., Wu,Q., Grundke-Iqbal,I. and
Iqbal,K.
TITLE Phosphorylation of tau at both Thr 231 and Ser 262 is required for
maximal inhibition of its binding to microtubules
JOURNAL Arch. Biochem. Biophys. 357 (2), 299-309 (1998)
PUBMED 9735171
REFERENCE 14 (sites)
AUTHORS Michel,G., Mercken,M., Murayama,M., Noguchi,K., Ishiguro,K.,
Imahori,K. and Takashima,A.
TITLE Characterization of tau phosphorylation in glycogen synthase
kinase-3beta and cyclin dependent kinase-5 activator (p23)
transfected cells
JOURNAL Biochim. Biophys. Acta 1380 (2), 177-182 (1998)
PUBMED 9565682
REFERENCE 15 (sites)
AUTHORS Paudel,H.K.
TITLE Phosphorylation by neuronal cdc2-like protein kinase promotes
dimerization of Tau protein in vitro
JOURNAL J. Biol. Chem. 272 (45), 28328-28334 (1997)
PUBMED 9353289
REFERENCE 16 (sites)
AUTHORS Goedert,M., Hasegawa,M., Jakes,R., Lawler,S., Cuenda,A. and
Cohen,P.
TITLE Phosphorylation of microtubule-associated protein tau by
stress-activated protein kinases
JOURNAL FEBS Lett. 409 (1), 57-62 (1997)
PUBMED 9199504
REFERENCE 17 (residues 1 to 292)
AUTHORS Morishima-Kawashima,M., Hasegawa,M., Takio,K., Suzuki,M.,
Yoshida,H., Watanabe,A., Titani,K. and Ihara,Y.
TITLE Hyperphosphorylation of tau in PHF
JOURNAL Neurobiol. Aging 16 (3), 365-371 (1995)
PUBMED 7566346
REMARK Review article
REFERENCE 18 (sites)
AUTHORS Morishima-Kawashima,M., Hasegawa,M., Takio,K., Suzuki,M.,
Yoshida,H., Watanabe,A., Titani,K. and Ihara,Y.
TITLE Hyperphosphorylation of tau in PHF
JOURNAL Neurobiol. Aging 16 (3), 365-371 (1995)
PUBMED 7566346
REFERENCE 19 (residues 1 to 292)
AUTHORS Ino,H., Ishizuka,T., Chiba,T. and Tatibana,M.
TITLE Expression of CDK5 (PSSALRE kinase), a neural cdc2-related protein
kinase, in the mature and developing mouse central and peripheral
nervous systems
JOURNAL Brain Res. 661 (1-2), 196-206 (1994)
PUBMED 7834371
REFERENCE 20 (residues 1 to 292)
AUTHORS Goedert,M., Cohen,E.S., Jakes,R. and Cohen,P.
TITLE p42 MAP kinase phosphorylation sites in microtubule-associated
protein tau are dephosphorylated by protein phosphatase 2A1.
Implications for Alzheimer's disease [corrected]
JOURNAL FEBS Lett. 312 (1), 95-99 (1992)
PUBMED 1330687
REMARK Erratum:[FEBS Lett 1992 Nov 23;313(2):203]
REFERENCE 21 (residues 1 to 292)
AUTHORS Meyerson,M., Enders,G.H., Wu,C.L., Su,L.K., Gorka,C., Nelson,C.,
Harlow,E. and Tsai,L.H.
TITLE A family of human cdc2-related protein kinases
JOURNAL EMBO J. 11 (8), 2909-2917 (1992)
PUBMED 1639063
REFERENCE 22 (residues 1 to 292)
AUTHORS Ameli,N.O., Teymoorian,G.A., Saleh,H. and Slamdoost,A.
TITLE Proceedings: Aneurysmal bone cysts of the spine
JOURNAL Acta Neurochir (Wien) 31 (3-4), 273 (1975)
PUBMED 1181841
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BU527089.1 and CA429180.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..292
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="7"
/map="7q36"
Protein 1..292
/product="cyclin-dependent kinase 5"
/EC_number="2.7.11.22"
/note="protein kinase CDK5 splicing"
/calculated_mol_wt=33173
Site 15
/site_type="phosphorylation"
/experiment="experimental evidence, no additional details
recorded"
/citation=[8]
/db_xref="HPRD:00655"
Site 15
/site_type="phosphorylation"
/experiment="experimental evidence, no additional details
recorded"
/citation=[9]
/db_xref="HPRD:01809"
Site 159
/site_type="phosphorylation"
/experiment="experimental evidence, no additional details
recorded"
/citation=[10]
/db_xref="HPRD:02920"
Site 231
/site_type="phosphorylation"
/experiment="experimental evidence, no additional details
recorded"
/citation=[7]
/citation=[11]
/citation=[12]
/citation=[13]
/citation=[14]
/citation=[15]
/citation=[16]
/citation=[17]
/db_xref="HPRD:01142"
Site 287
/site_type="phosphorylation"
/experiment="experimental evidence, no additional details
recorded"
/citation=[6]
/db_xref="HPRD:02127"
CDS 1..292
/gene="CDK5"
/gene_synonym="PSSALRE"
/coded_by="NM_004935.2:62..940"
/db_xref="GeneID:1020"
/db_xref="HGNC:1774"
/db_xref="HPRD:00449"
/db_xref="MIM:123831"
ORIGIN
1 mqkyekleki gegtygtvfk aknretheiv alkrvrlddd degvpssalr eicllkelkh
61 knivrlhdvl hsdkkltlvf efcdqdlkky fdscngdldp eivksflfql lkglgfchsr
121 nvlhrdlkpq nllinrngel kladfglara fgipvrcysa evvtlwyrpp dvlfgaklys
181 tsidmwsagc ifaelanagr plfpgndvdd qlkrifrllg tpteeqwpsm tklpdykpyp
241 mypattslvn vvpklnatgr dllqnllkcn pvqrisaeea lqhpyfsdfc pp
//