LOCUS       NP_004621                639 aa            linear   PRI 21-SEP-2008
DEFINITION  splicing factor 1 isoform 1 [Homo sapiens].
ACCESSION   NP_004621
VERSION     NP_004621.2  GI:42544130
DBSOURCE    REFSEQ: accession NM_004630.2
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 639)
  AUTHORS   Rino,J., Desterro,J.M., Pacheco,T.R., Gadella,T.W. Jr. and
            Carmo-Fonseca,M.
  TITLE     Splicing factors SF1 and U2AF associate in extraspliceosomal
            complexes
  JOURNAL   Mol. Cell. Biol. 28 (9), 3045-3057 (2008)
   PUBMED   18285458
  REMARK    GeneRIF: SF1 and U2AF form extraspliceosomal complexes before and
            after taking part in the assembly of catalytic spliceosomes.
REFERENCE   2  (residues 1 to 639)
  AUTHORS   Olejnik-Schmidt,A.K., Schmidt,M.T., Kedzia,W. and
            Gozdzicka-Jozefiak,A.
  TITLE     Search for cellular partners of human papillomavirus type 16 E2
            protein
  JOURNAL   Arch. Virol. 153 (5), 983-990 (2008)
   PUBMED   18305892
REFERENCE   3  (residues 1 to 639)
  AUTHORS   Shitashige,M., Naishiro,Y., Idogawa,M., Honda,K., Ono,M.,
            Hirohashi,S. and Yamada,T.
  TITLE     Involvement of splicing factor-1 in beta-catenin/T-cell
            factor-4-mediated gene transactivation and pre-mRNA splicing
  JOURNAL   Gastroenterology 132 (3), 1039-1054 (2007)
   PUBMED   17383426
  REMARK    GeneRIF: SF1 was essential for the induction of alternative mRNA
            splicing by the beta-catenin/TCF4 complex.
REFERENCE   4  (residues 1 to 639)
  AUTHORS   Olsen,J.V., Blagoev,B., Gnad,F., Macek,B., Kumar,C., Mortensen,P.
            and Mann,M.
  TITLE     Global, in vivo, and site-specific phosphorylation dynamics in
            signaling networks
  JOURNAL   Cell 127 (3), 635-648 (2006)
   PUBMED   17081983
REFERENCE   5  (residues 1 to 639)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat. Biotechnol. 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   6  (residues 1 to 639)
  AUTHORS   Abovich,N. and Rosbash,M.
  TITLE     Cross-intron bridging interactions in the yeast commitment complex
            are conserved in mammals
  JOURNAL   Cell 89 (3), 403-412 (1997)
   PUBMED   9150140
REFERENCE   7  (residues 1 to 639)
  AUTHORS   Arning,S., Gruter,P., Bilbe,G. and Kramer,A.
  TITLE     Mammalian splicing factor SF1 is encoded by variant cDNAs and binds
            to RNA
  JOURNAL   RNA 2 (8), 794-810 (1996)
   PUBMED   8752089
REFERENCE   8  (residues 1 to 639)
  AUTHORS   Naumovski,L. and Cleary,M.L.
  TITLE     The p53-binding protein 53BP2 also interacts with Bc12 and impedes
            cell cycle progression at G2/M
  JOURNAL   Mol. Cell. Biol. 16 (7), 3884-3892 (1996)
   PUBMED   8668206
REFERENCE   9  (residues 1 to 639)
  AUTHORS   Toda,T., Iida,A., Miwa,T., Nakamura,Y. and Imai,T.
  TITLE     Isolation and characterization of a novel gene encoding nuclear
            protein at a locus (D11S636) tightly linked to multiple endocrine
            neoplasia type 1 (MEN1)
  JOURNAL   Hum. Mol. Genet. 3 (3), 465-470 (1994)
   PUBMED   7912130
REFERENCE   10 (residues 1 to 639)
  AUTHORS   Kramer,A.
  TITLE     Purification of splicing factor SF1, a heat-stable protein that
            functions in the assembly of a presplicing complex
  JOURNAL   Mol. Cell. Biol. 12 (10), 4545-4552 (1992)
   PUBMED   1406644
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC034451.1, D26120.1, Y08765.1, BC011657.2 and BU624935.1.
            On Feb 13, 2004 this sequence version replaced gi:4759340.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the
            Entrez Gene record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..639
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13"
     Protein         1..639
                     /product="splicing factor 1 isoform 1"
                     /note="zinc finger protein 162"
                     /calculated_mol_wt=68199
     CDS             1..639
                     /gene="SF1"
                     /gene_synonym="ZFM1"
                     /gene_synonym="ZNF162"
                     /gene_synonym="D11S636"
                     /coded_by="NM_004630.2:378..2297"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS31599.1"
                     /db_xref="GeneID:7536"
                     /db_xref="HGNC:12950"
                     /db_xref="HPRD:03306"
                     /db_xref="MIM:601516"
ORIGIN      
        1 matganatpl dfpskkrkrs rwnqdtmeqk tvipgmptvi ppgltreqer ayivqlqied
       61 ltrklrtgdl gippnpedrs pspepiynse gkrlntrefr trkkleeerh nlitemvaln
      121 pdfkppadyk ppatrvsdkv mipqdeypei nfvglligpr gntlknieke cnakimirgk
      181 gsvkegkvgr kdgqmlpged eplhalvtan tmenvkkave qirnilkqgi etpedqndlr
      241 kmqlrelarl ngtlreddnr ilrpwqsset rsitnttvct kcggaghias dckfqrpgdp
      301 qsaqdkarmd keylslmael geapvpasvg stsgpattpl asaprpaapa nnppppslms
      361 ttqsrppwmn sgpsesrpyh gmhgggpggp gggphsfphp lpsltgghgg hpmqhnpngp
      421 pppwmqpppp pmnqgphppg hhgpppmdqy lgstpvgsgv yrlhqgkgmm ppppmgmmpp
      481 pppppsgqpp pppsgplppw qqqqqqpppp pppsssmass tplpwqqntt ttttsagtgs
      541 ippwqqqqaa aaaspgapqm qgnptmvplp pgvqpplppg appppppppp gsagmmyapp
      601 ppppppmdps nfvtmmgmgv agmppfgmpp appppppqn
//