LOCUS NP_004095 2511 aa linear PRI 24-OCT-2008
DEFINITION fatty acid synthase [Homo sapiens].
ACCESSION NP_004095
VERSION NP_004095.4 GI:41872631
DBSOURCE REFSEQ: accession NM_004104.4
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 2511)
AUTHORS Lu,Y., Dolle,M.E., Imholz,S., Slot,R.V., Verschuren,W.M.,
Wijmenga,C., Feskens,E.J. and Boer,J.M.
TITLE Multiple genetic variants along candidate pathways influence plasma
high-density lipoprotein cholesterol concentrations
JOURNAL J. Lipid Res. (2008) In press
PUBMED 18660489
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
Publication Status: Available-Online prior to print
REFERENCE 2 (residues 1 to 2511)
AUTHORS Di Vizio,D., Adam,R.M., Kim,J., Kim,R., Sotgia,F., Williams,T.,
Demichelis,F., Solomon,K.R., Loda,M., Rubin,M.A., Lisanti,M.P. and
Freeman,M.R.
TITLE Caveolin-1 interacts with a lipid raft-associated population of
fatty acid synthase
JOURNAL Cell Cycle 7 (14), 2257-2267 (2008)
PUBMED 18635971
REMARK GeneRIF: These findings suggest that FASN and Cav-1 physically and
functionally interact in PCa cells.
REFERENCE 3 (residues 1 to 2511)
AUTHORS Silva,S.D., Cunha,I.W., Rangel,A.L., Jorge,J., Zecchin,K.G.,
Agostini,M., Kowalski,L.P., Coletta,R.D. and Graner,E.
TITLE Differential expression of fatty acid synthase (FAS) and ErbB2 in
nonmalignant and malignant oral keratinocytes
JOURNAL Virchows Arch. 453 (1), 57-67 (2008)
PUBMED 18528705
REMARK GeneRIF: Fatty acid synthase is overexpressed in oral or head and
neck squamous cell carcinomas and hyperkeratotic oral epithelium.
REFERENCE 4 (residues 1 to 2511)
AUTHORS Oem,J.K., Jackel-Cram,C., Li,Y.P., Zhou,Y., Zhong,J., Shimano,H.,
Babiuk,L.A. and Liu,Q.
TITLE Activation of sterol regulatory element-binding protein 1c and
fatty acid synthase transcription by hepatitis C virus
non-structural protein 2
JOURNAL J. Gen. Virol. 89 (PT 5), 1225-1230 (2008)
PUBMED 18420801
REMARK GeneRIF: Taken together, results suggest that HCV NS2 can
upregulate the transcription of SREBP-1c and FAS, and thus is
probably a contributing factor for HCV-associated steatosis.
REFERENCE 5 (residues 1 to 2511)
AUTHORS Silva,S.D., Perez,D.E., Nishimoto,I.N., Alves,F.A., Pinto,C.A.,
Kowalski,L.P. and Graner,E.
TITLE Fatty acid synthase expression in squamous cell carcinoma of the
tongue: clinicopathological findings
JOURNAL Oral Dis 14 (4), 376-382 (2008)
PUBMED 18410580
REMARK GeneRIF: expression in squamous cell carcinoma of the tongue is
associated with microscopic characteristics that determine disease
progression and prognosis
REFERENCE 6 (residues 1 to 2511)
AUTHORS Jayakumar,A., Tai,M.H., Huang,W.Y., al-Feel,W., Hsu,M.,
Abu-Elheiga,L., Chirala,S.S. and Wakil,S.J.
TITLE Human fatty acid synthase: properties and molecular cloning
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (19), 8695-8699 (1995)
PUBMED 7567999
REFERENCE 7 (residues 1 to 2511)
AUTHORS Semenkovich,C.F., Coleman,T. and Fiedorek,F.T. Jr.
TITLE Human fatty acid synthase mRNA: tissue distribution, genetic
mapping, and kinetics of decay after glucose deprivation
JOURNAL J. Lipid Res. 36 (7), 1507-1521 (1995)
PUBMED 7595075
REFERENCE 8 (residues 1 to 2511)
AUTHORS Wakil,S.J.
TITLE Fatty acid synthase, a proficient multifunctional enzyme
JOURNAL Biochemistry 28 (11), 4523-4530 (1989)
PUBMED 2669958
REMARK Review article
REFERENCE 9 (residues 1 to 2511)
AUTHORS Lejin,D.
TITLE [Viscosimetry in clinical practice]
JOURNAL Med. Pregl. 30 (9-10), 477-482 (1977)
PUBMED 600212
REFERENCE 10 (residues 1 to 2511)
AUTHORS Wronkowski,Z.
TITLE [Cancer diagnosis of the respiratory system]
JOURNAL Pieleg Polozna 12, 7-8 (1975)
PUBMED 1044453
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC063242.1, BC021544.2,
BC007267.1 and S80437.1.
On Feb 3, 2004 this sequence version replaced gi:21618359.
Summary: The enzyme encoded by this gene is a multifunctional
protein. Its main function is to catalyze the synthesis of
palmitate from acetyl-CoA and malonyl-CoA, in the presence of
NADPH, into long-chain saturated fatty acids. In some cancer cell
lines, this protein has been found to be fused with estrogen
receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused
in-frame with the C-terminus of ER-alpha. [provided by RefSeq].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..2511
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q25"
Protein 1..2511
/product="fatty acid synthase"
/EC_number="2.3.1.85"
/EC_number="2.3.1.38"
/EC_number="2.3.1.39"
/EC_number="2.3.1.41"
/EC_number="3.1.2.14"
/EC_number="1.3.1.10"
/EC_number="4.2.1.61"
/EC_number="1.1.1.100"
/calculated_mol_wt=273297
CDS 1..2511
/gene="FASN"
/gene_synonym="FAS"
/gene_synonym="OA-519"
/gene_synonym="MGC14367"
/gene_synonym="MGC15706"
/coded_by="NM_004104.4:118..7653"
/db_xref="CCDS:CCDS11801.1"
/db_xref="GeneID:2194"
/db_xref="HGNC:3594"
/db_xref="HPRD:02567"
/db_xref="MIM:600212"
ORIGIN
1 meevviagms gklpesenlq efwdnliggv dmvtdddrrw kaglyglprr sgklkdlsrf
61 dasffgvhpk qahtmdpqlr lllevtyeai vdgginpdsl rgthtgvwvg vsgsetseal
121 srdpetlvgy smvgcqramm anrlsfffdf rgpsialdta cssslmalqn ayqaihsgqc
181 paaivgginv llkpntsvqf lrlgmlspeg tckafdtagn gycrsegvva vlltkkslar
241 rvyatilnag tntdgfkeqg vtfpsgdiqe qlirslyqsa gvapesfeyi eahgtgtkvg
301 dpqelngitr alcatrqepl ligstksnmg hpepasglaa lakvllsleh glwapnlhfh
361 spnpeipall dgrlqvvdqp lpvrggnvgi nsfgfggsnv hiilrpntqp ppapaphatl
421 prllrasgrt peavqklleq glrhsqdlaf lsmlndiaav patampfrgy avlggerggp
481 evqqvpager plwficsgmg tqwrgmglsl mrldrfrdsi lrsdeavkpf glkvsqllls
541 tdestfddiv hsfvsltaiq iglidllscm glrpdgivgh slgevacgya dgclsqeeav
601 laaywrgqci keahlppgam aavglsweec kqrcppgvvp achnskdtvt isgpqapvfe
661 fveqlrkegv fakevrtggm afhsyfmeai appllqelkk virepkprsa rwlstsipea
721 qwhsslarts saeynvnnlv spvlfqealw hvpehavvle iaphallqav lkrglkpsct
781 iiplmkkdhr dnlefflagi grlhlsgida npnalfppve fpaprgtpli splikwdhsl
841 awdvpaaedf pngsgspsaa iynidtsses pdhylvdhtl dgrvlfpatg ylsivwktla
901 ralglgveql pvvfedvvlh qatilpktgt vslevrllea srafevseng nlvvsgkvyq
961 wddpdprlfd hpesptpnpt eplflaqaev ykelrlrgyd ygphfqgile aslegdsgrl
1021 lwkdnwvsfm dtmlqmsilg sakhglylpt rvtaihidpa thrqklytlq dkaqvadvvv
1081 srwlrvtvag gvhisglhte saprrqqeqq vpilekfcft phteegclse raalqeelql
1141 ckglvqalqt kvtqqglkmv vpgldgaqip rdpsqqelpr llsaacrlql ngnlqlelaq
1201 vlaqerpklp edpllsglld spalkacldt avenmpslkm kvvevlaghg hlysripgll
1261 sphpllqlsy tatdrhpqal eaaqaelqqh dvaqgqwdpa dpapsalgsa dllvcncava
1321 algdpasals nmvaalregg flllhtllrg hplgdivafl tstepqygqg ilsqdawesl
1381 fsrvslrlvg lkksfygstl flcrrptpqd spiflpvddt sfrwveslkg iladedssrp
1441 vwlkaincat sgvvglvncl rrepggnrlr cvllsnlsst shvpevdpgs aelqkvlqgd
1501 lvmnvyrdga wgafrhflle edkpeeptah afvstltrgd lssirwvcss lrhaqptcpg
1561 aqlctvyyas lnfrdimlat gklspdaipg kwtsqdsllg mefsgrdasg krvmglvpak
1621 glatsvllsp dflwdvpsnw tleeaasvpv vystayyalv vrgrvrpget llihsgsggv
1681 gqaaiaials lgcrvfttvg saekraylqa rfpqldstsf ansrdtsfeq hvlwhtggkg
1741 vdlvlnslae eklqasvrcl athgrfleig kfdlsqnhpl gmaiflknvt fhgvlldaff
1801 nessadwrev walvqagird gvvrplkctv fhgaqvedaf rymaqgkhig kvvvqvlaee
1861 peavlkgakp klmsaisktf cpahksyiia gglggfglel aqwliqrgvq klvltsrsgi
1921 rtgyqakqvr rwrrqgvqvq vstsnissle gargliaeaa qlgpvggvfn lavvlrdgll
1981 enqtpeffqd vckpkysgtl nldrvtreac peldyfvvfs svscgrgnag qsnygfansa
2041 mericekrrh eglpglavqw gaigdvgilv etmstndtiv sgtlpqrmas clevldlfln
2101 qphmvlssfv laekaaayrd rdsqrdlvea vahilgirdl aavnldssla dlgldslmsv
2161 evrqtlerel nlvlsvrevr qltlrklqel sskadeasel acptpkedgl aqqqtqlnlr
2221 sllvnpegpt lmrlnsvqss erplflvhpi egsttvfhsl asrlsiptyg lqctraapld
2281 sihslaayyi dcirqvqpeg pyrvagysyg acvafemcsq lqaqqspapt hnslflfdgs
2341 ptyvlaytqs yrakltpgce aeaeteaicf fvqqftdmeh nrvleallpl kgleervaaa
2401 vdliikshqg ldrqelsfaa rsfyyklraa eqytpkakyh gnvmllrakt ggaygedlga
2461 dynlsqvcdg kvsvhviegd hrtllegsgl esiisiihss laeprvsvre g
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