LOCUS NP_003378 503 aa linear PRI 16-MAR-2008 DEFINITION WAS/WASL interacting protein family, member 1 [Homo sapiens]. ACCESSION NP_003378 VERSION NP_003378.3 GI:38373695 DBSOURCE REFSEQ: accession NM_003387.4 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 503) AUTHORS Krzewski,K., Chen,X. and Strominger,J.L. TITLE WIP is essential for lytic granule polarization and NK cell cytotoxicity JOURNAL Proc. Natl. Acad. Sci. U.S.A. 105 (7), 2568-2573 (2008) PUBMED 18258743 REMARK GeneRIF: WIP is involved in lytic granule transport and is essential for regulation of Natural killer cell cytotoxic function REFERENCE 2 (residues 1 to 503) AUTHORS Tsuboi,S. and Meerloo,J. TITLE Wiskott-Aldrich syndrome protein is a key regulator of the phagocytic cup formation in macrophages JOURNAL J. Biol. Chem. 282 (47), 34194-34203 (2007) PUBMED 17890224 REMARK GeneRIF: that WASP and WASP-interacting protein (WIP) form a complex at the phagocytic cup and that the WASP.WIP complex plays a critical role in the phagocytic cup formation. REFERENCE 3 (residues 1 to 503) AUTHORS Anton,I.M., Jones,G.E., Wandosell,F., Geha,R. and Ramesh,N. TITLE WASP-interacting protein (WIP): working in polymerisation and much more JOURNAL Trends Cell Biol. 17 (11), 555-562 (2007) PUBMED 17949983 REMARK GeneRIF: In this review, in addition to its WASP-independent functions, the role of WIP is to regulate the activity and stability of WASP and shuttle WASP to areas of actin assembly. Review article REFERENCE 4 (residues 1 to 503) AUTHORS Dong,X., Patino-Lopez,G., Candotti,F. and Shaw,S. TITLE Structure-function analysis of the WIP role in T cell receptor-stimulated NFAT activation: evidence that WIP-WASP dissociation is not required and that the WIP NH2 terminus is inhibitory JOURNAL J. Biol. Chem. 282 (41), 30303-30310 (2007) PUBMED 17711847 REMARK GeneRIF: the WIP-WASP complex plays an important role in WASP stabilization and NFAT activation REFERENCE 5 (residues 1 to 503) AUTHORS de la Fuente,M.A., Sasahara,Y., Calamito,M., Anton,I.M., Elkhal,A., Gallego,M.D., Suresh,K., Siminovitch,K., Ochs,H.D., Anderson,K.C., Rosen,F.S., Geha,R.S. and Ramesh,N. TITLE WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP) JOURNAL Proc. Natl. Acad. Sci. U.S.A. 104 (3), 926-931 (2007) PUBMED 17213309 REMARK GeneRIF: WASP-interacting protein stabilizes Wiskott-Aldrich syndrome protein(WASP) and suggest that it may also be important for its function REFERENCE 6 (residues 1 to 503) AUTHORS Vaduva,G., Martinez-Quiles,N., Anton,I.M., Martin,N.C., Geha,R.S., Hopper,A.K. and Ramesh,N. TITLE The human WASP-interacting protein, WIP, activates the cell polarity pathway in yeast JOURNAL J. Biol. Chem. 274 (24), 17103-17108 (1999) PUBMED 10358064 REFERENCE 7 (residues 1 to 503) AUTHORS Stewart,D.M., Tian,L. and Nelson,D.L. TITLE Mutations that cause the Wiskott-Aldrich syndrome impair the interaction of Wiskott-Aldrich syndrome protein (WASP) with WASP interacting protein JOURNAL J. Immunol. 162 (8), 5019-5024 (1999) PUBMED 10202051 REFERENCE 8 (residues 1 to 503) AUTHORS Ramesh,N., Anton,I.M., Martinez-Quiles,N. and Geha,R.S. TITLE Waltzing with WASP JOURNAL Trends Cell Biol. 9 (1), 15-19 (1999) PUBMED 10087612 REMARK Review article REFERENCE 9 (residues 1 to 503) AUTHORS Anton,I.M., Lu,W., Mayer,B.J., Ramesh,N. and Geha,R.S. TITLE The Wiskott-Aldrich syndrome protein-interacting protein (WIP) binds to the adaptor protein Nck JOURNAL J. Biol. Chem. 273 (33), 20992-20995 (1998) PUBMED 9694849 REFERENCE 10 (residues 1 to 503) AUTHORS Ramesh,N., Anton,I.M., Hartwig,J.H. and Geha,R.S. TITLE WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells JOURNAL Proc. Natl. Acad. Sci. U.S.A. 94 (26), 14671-14676 (1997) PUBMED 9405671 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA674627.1, BX640870.1, BC110288.1, AL529597.3, BC002914.2, AL832275.1, BM475558.1, AA903457.1 and BC045584.1. On Nov 18, 2003 this sequence version replaced gi:8400740. Summary: This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. FEATURES Location/Qualifiers source 1..503 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="2" /map="2q31.1" Protein 1..503 /product="WAS/WASL interacting protein family, member 1" /note="Wiskott-Aldrich syndrome protein interacting protein" /calculated_mol_wt=51128 CDS 1..503 /gene="WIPF1" /gene_synonym="WIP" /gene_synonym="PRPL-2" /gene_synonym="WASPIP" /gene_synonym="MGC111041" /coded_by="NM_003387.4:101..1612" /db_xref="CCDS:CCDS2260.1" /db_xref="GeneID:7456" /db_xref="HGNC:12736" /db_xref="HPRD:03835" /db_xref="MIM:602357" ORIGIN 1 mpvppppapp ppptfalant ekptlnkteq agrnallsdi skgkklkktv tndrsapild 61 kpkgagaggg gggfgggggf gggggggggg sfggggppgl gglfqagmpk lrstanrdnd 121 sggsrppllp pggrstsakp fsppsgpgrf pvpspghrsg ppepqrnrmp pprpdvgskp 181 dsipppvpst prpiqssphn rgsppvpggp rqpspgptpp pfpgnrgtal gggsirqspl 241 sssspfsnrp plpptpsral ddkppppppp vgnrpsihre avpppppqnn kppvpstprp 301 sassqapppp pppsrpgppp lppsssgnde tprlpqrnls lssstpplps pgrsgplppp 361 pserppppvr dppgrsgplp ppppvsrngs tsralpatpq lpsrsgvdsp rsgprpplpp 421 drpsagappp pppstsirng fqdspcedew esrfyfhpis dlpppepyvq ttksypskla 481 rnesrsgsnr rergapplpp ipr //