LOCUS       NP_001032358             345 aa            linear   PRI 12-OCT-2008
DEFINITION  par-6 partitioning defective 6 homolog alpha isoform 2 [Homo
            sapiens].
ACCESSION   NP_001032358
VERSION     NP_001032358.1  GI:82659097
DBSOURCE    REFSEQ: accession NM_001037281.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 345)
  AUTHORS   Hartleben,B., Schweizer,H., Lubben,P., Bartram,M.P., Moller,C.C.,
            Herr,R., Wei,C., Neumann-Haefelin,E., Schermer,B., Zentgraf,H.,
            Kerjaschki,D., Reiser,J., Walz,G., Benzing,T. and Huber,T.B.
  TITLE     Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C
            (aPKC) complex to regulate podocyte cell polarity
  JOURNAL   J. Biol. Chem. 283 (34), 23033-23038 (2008)
   PUBMED   18562307
  REMARK    GeneRIF: Neph1-Nephrin proteins bind the Par3-Par6-atypical protein
            kinase C (aPKC) complex to regulate podocyte cell polarity
REFERENCE   2  (residues 1 to 345)
  AUTHORS   Rudolph,J.L., Shi,G.X., Erdogan,E., Fields,A.P. and Andres,D.A.
  TITLE     Rit mutants confirm role of MEK/ERK signaling in neuronal
            differentiation and reveal novel Par6 interaction
  JOURNAL   Biochim. Biophys. Acta 1773 (12), 1793-1800 (2007)
   PUBMED   17976838
  REMARK    GeneRIF: In vivo binding studies identified a novel mechanism of
            Par6 interaction, suggesting that the cell polarity machinery may
            serve to spatially restrict Rit signaling.
REFERENCE   3  (residues 1 to 345)
  AUTHORS   Simmers,M.B., Pryor,A.W. and Blackman,B.R.
  TITLE     Arterial shear stress regulates endothelial cell-directed
            migration, polarity, and morphology in confluent monolayers
  JOURNAL   Am. J. Physiol. Heart Circ. Physiol. 293 (3), H1937-H1946 (2007)
   PUBMED   17586613
  REMARK    GeneRIF: Shear stress-induced directed migratory polarity is
            modulated by exogenous growth factors and dependent on Par6
            activity and shear stress direction in endothelial cells
REFERENCE   4  (residues 1 to 345)
  AUTHORS   Cline,E.G. and Nelson,W.J.
  TITLE     Characterization of mammalian Par 6 as a dual-location protein
  JOURNAL   Mol. Cell. Biol. 27 (12), 4431-4443 (2007)
   PUBMED   17420281
  REMARK    GeneRIF: Par6 was characterized as a dual-location protein.
REFERENCE   5  (residues 1 to 345)
  AUTHORS   Weyrich,P., Neuscheler,D., Melzer,M., Hennige,A.M., Haring,H.U. and
            Lammers,R.
  TITLE     The Par6alpha/aPKC complex regulates Akt1 activity by
            phosphorylating Thr34 in the PH-domain
  JOURNAL   Mol. Cell. Endocrinol. 268 (1-2), 30-36 (2007)
   PUBMED   17335965
  REMARK    GeneRIF: Par6alpha-mediated inhibition of insulin-dependent
            glycogen synthesis in C2C12 cells depends on the direct interaction
            of Par6alpha with aPKC and on aPKC-mediated T34 phosphorylation of
            Akt1.
REFERENCE   6  (residues 1 to 345)
  AUTHORS   Suzuki,A., Yamanaka,T., Hirose,T., Manabe,N., Mizuno,K.,
            Shimizu,M., Akimoto,K., Izumi,Y., Ohnishi,T. and Ohno,S.
  TITLE     Atypical protein kinase C is involved in the evolutionarily
            conserved par protein complex and plays a critical role in
            establishing epithelia-specific junctional structures
  JOURNAL   J. Cell Biol. 152 (6), 1183-1196 (2001)
   PUBMED   11257119
REFERENCE   7  (residues 1 to 345)
  AUTHORS   Johansson,A., Driessens,M. and Aspenstrom,P.
  TITLE     The mammalian homologue of the Caenorhabditis elegans polarity
            protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and
            Rac1
  JOURNAL   J. Cell. Sci. 113 (PT 18), 3267-3275 (2000)
   PUBMED   10954424
REFERENCE   8  (residues 1 to 345)
  AUTHORS   Joberty,G., Petersen,C., Gao,L. and Macara,I.G.
  TITLE     The cell-polarity protein Par6 links Par3 and atypical protein
            kinase C to Cdc42
  JOURNAL   Nat. Cell Biol. 2 (8), 531-539 (2000)
   PUBMED   10934474
REFERENCE   9  (residues 1 to 345)
  AUTHORS   Qiu,R.G., Abo,A. and Steven Martin,G.
  TITLE     A human homolog of the C. elegans polarity determinant Par-6 links
            Rac and Cdc42 to PKCzeta signaling and cell transformation
  JOURNAL   Curr. Biol. 10 (12), 697-707 (2000)
   PUBMED   10873802
REFERENCE   10 (residues 1 to 345)
  AUTHORS   Rousset,R., Fabre,S., Desbois,C., Bantignies,F. and Jalinot,P.
  TITLE     The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction
            with the PDZ domain of cellular proteins
  JOURNAL   Oncogene 16 (5), 643-654 (1998)
   PUBMED   9482110
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF252292.1 and BC015626.2.
            
            Summary: This gene is a member of the PAR6 family and encodes a
            protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a
            semi-Cdc42/Rac interactive binding (CRIB) domain. This cell
            membrane protein is involved in asymmetrical cell division and cell
            polarization processes as a member of a multi-protein complex. The
            protein also has a role in the epithelial-to-mesenchymal transition
            (EMT) that characterizes the invasive phenotype associated with
            metastatic carcinomas. Alternate transcriptional splice variants,
            encoding different isoforms, have been characterized. [provided by
            RefSeq].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the coding region, compared to variant 1, resulting
            in a protein (isoform 2) that is one amino acid shorter than
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the
            Entrez Gene record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..345
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     Protein         1..345
                     /product="par-6 partitioning defective 6 homolog alpha
                     isoform 2"
                     /note="Tax-interacting protein 40; partitioning
                     defective-6 homolog alpha; partitioning-defective protein
                     6"
                     /calculated_mol_wt=37186
     CDS             1..345
                     /gene="PARD6A"
                     /gene_synonym="PAR6"
                     /gene_synonym="PAR6C"
                     /gene_synonym="TAX40"
                     /gene_synonym="PAR-6A"
                     /gene_synonym="TIP-40"
                     /gene_synonym="PAR6alpha"
                     /coded_by="NM_001037281.1:92..1129"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:50855"
                     /db_xref="HGNC:15943"
                     /db_xref="HPRD:06316"
                     /db_xref="MIM:607484"
ORIGIN      
        1 marpqrtpar spdsivevks kfdaefrrfa lprasvsgfq efsrllravh qipgldvllg
       61 ytdahgdllp ltnddslhra lasgppplrl lvqkreadss glafasnslq rrkkglllrp
      121 vaplrtrppl lislpqdfrq vssvidvdll pethrrvrlh khgsdrplgf yirdgmsvrv
      181 apqglervpg ifisrlvrgg laestgllav sdeilevngi evagktldqv tdmmvanshn
      241 livtvkpanq rnnvvrgasg rltgppsagp gpaepdsddd ssdlvienrq ppssnglsqg
      301 ppcwdlhpgc rhpgtrsslp slddqeqass gwgsrirgdg sgfsl
//