LOCUS       NP_001026786             385 aa            linear   PRI 22-OCT-2008
DEFINITION  aldehyde dehydrogenase 3B2 [Homo sapiens].
ACCESSION   NP_001026786
VERSION     NP_001026786.1  GI:73695881
DBSOURCE    REFSEQ: accession NM_001031615.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 385)
  AUTHORS   Suzuki,Y., Yamashita,R., Shirota,M., Sakakibara,Y., Chiba,J.,
            Mizushima-Sugano,J., Nakai,K. and Sugano,S.
  TITLE     Sequence comparison of human and mouse genes reveals a homologous
            block structure in the promoter regions
  JOURNAL   Genome Res. 14 (9), 1711-1718 (2004)
   PUBMED   15342556
REFERENCE   2  (residues 1 to 385)
  AUTHORS   Hsu,L.C., Chang,W.C. and Yoshida,A.
  TITLE     Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic
            organization and gene structure comparison
  JOURNAL   Gene 189 (1), 89-94 (1997)
   PUBMED   9161417
REFERENCE   3  (residues 1 to 385)
  AUTHORS   Hsu,L.C. and Chang,W.C.
  TITLE     Sequencing and expression of the human ALDH8 encoding a new member
            of the aldehyde dehydrogenase family
  JOURNAL   Gene 174 (2), 319-322 (1996)
   PUBMED   8890755
REFERENCE   4  (residues 1 to 385)
  AUTHORS   Hsu,L.C., Chang,W.C., Lin,S.W. and Yoshida,A.
  TITLE     Cloning and characterization of genes encoding four additional
            human aldehyde dehydrogenase isozymes
  JOURNAL   Adv. Exp. Med. Biol. 372, 159-168 (1995)
   PUBMED   7484374
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC007685.2, AK092464.1 and
            BG009508.1.
            
            Summary: This gene encodes a member of the aldehyde dehydrogenase
            family, a group of isozymes that may play a major role in the
            detoxification of aldehydes generated by alcohol metabolism and
            lipid peroxidation. The gene of this particular family member is
            over 10 kb in length. The expression of these transcripts is
            restricted to the salivary gland among the human tissues examined.
            Alternate transcriptional splice variants have been characterized.
            [provided by RefSeq].
            
            Transcript Variant: This variant (2) uses an alternate upstream
            transcription initiation site and has a distinct 5' UTR, compared
            to variant 1. Variants 1 and 2 encode the same protein.
FEATURES             Location/Qualifiers
     source          1..385
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13"
     Protein         1..385
                     /product="aldehyde dehydrogenase 3B2"
                     /EC_number="1.2.1.5"
                     /note="aldehyde dehydrogenase 8; acetaldehyde
                     dehydrogenase 8"
                     /calculated_mol_wt=42493
     CDS             1..385
                     /gene="ALDH3B2"
                     /gene_synonym="ALDH8"
                     /coded_by="NM_001031615.1:284..1441"
                     /db_xref="CCDS:CCDS31622.1"
                     /db_xref="GeneID:222"
                     /db_xref="HGNC:411"
                     /db_xref="HPRD:03559"
                     /db_xref="MIM:601917"
ORIGIN      
        1 mkdeprstnl fmkldsvfiw kepfglvlii apwnyplnlt lvllvgalaa gscvvlkpse
       61 isqgtekvla evlpqyldqs cfavvlggpq etgqllehkl dyifftgspr vgkivmtaat
      121 khltpvtlel ggknpcyvdd ncdpqtvanr vawfcyfnag qtcvapdyvl cspemqerll
      181 palqstitrf ygddpqsspn lgriinqkqf qrlrallgcg rvaiggqsne sdryiaptvl
      241 vdvqetepvm qeeifgpilp ivnvqsvdea ikfinrqekp lalyafsnss qvvnqmlert
      301 ssgsfggneg ftyisllsvp fggvghsgmg ryhgkftfdt fshhrtclla psgleklkei
      361 hyppytdwnq qllrwgmgsq sctll
//