LOCUS NP_001025173 532 aa linear PRI 13-APR-2008
DEFINITION growth factor receptor-bound protein 7 [Homo sapiens].
ACCESSION NP_001025173
VERSION NP_001025173.1 GI:71979667
DBSOURCE REFSEQ: accession NM_001030002.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 532)
AUTHORS Bai,T. and Luoh,S.W.
TITLE GRB-7 facilitates HER-2/Neu-mediated signal transduction and tumor
formation
JOURNAL Carcinogenesis 29 (3), 473-479 (2008)
PUBMED 17916906
REMARK GeneRIF: GRB-7 over-expression plays pivotal roles in activating
signal transduction and promoting tumor growth in breast cancer
cells with chromosome 17q11-21 amplification
REFERENCE 2 (residues 1 to 532)
AUTHORS Spuches,A.M., Argiros,H.J., Lee,K.H., Haas,L.L., Pero,S.C.,
Krag,D.N., Roller,P.P., Wilcox,D.E. and Lyons,B.A.
TITLE Calorimetric investigation of phosphorylated and non-phosphorylated
peptide ligand binding to the human Grb7-SH2 domain
JOURNAL J. Mol. Recognit. 20 (4), 245-252 (2007)
PUBMED 17705331
REMARK GeneRIF: The solution structure and the backbone relaxation
behavior of the Grb7-SH2/erbB2 peptide complex.
REFERENCE 3 (residues 1 to 532)
AUTHORS Itoh,S., Taketomi,A., Tanaka,S., Harimoto,N., Yamashita,Y.,
Aishima,S., Maeda,T., Shirabe,K., Shimada,M. and Maehara,Y.
TITLE Role of growth factor receptor bound protein 7 in hepatocellular
carcinoma
JOURNAL Mol. Cancer Res. 5 (7), 667-673 (2007)
PUBMED 17634422
REMARK GeneRIF: Grb7 plays an important role in hepatocellular carcinoma
progression and is strongly associated with expression of focal
adhesion kinase.
REFERENCE 4 (residues 1 to 532)
AUTHORS Pero,S.C., Shukla,G.S., Cookson,M.M., Flemer,S. Jr. and Krag,D.N.
TITLE Combination treatment with Grb7 peptide and Doxorubicin or
Trastuzumab (Herceptin) results in cooperative cell growth
inhibition in breast cancer cells
JOURNAL Br. J. Cancer 96 (10), 1520-1525 (2007)
PUBMED 17426702
REMARK GeneRIF: The Grb7 peptide has potential to be developed as a
therapeutic agent alone, or in combination with traditional
chemotherapy.
REFERENCE 5 (residues 1 to 532)
AUTHORS Benusiglio,P.R., Pharoah,P.D., Smith,P.L., Lesueur,F., Conroy,D.,
Luben,R.N., Dew,G., Jordan,C., Dunning,A., Easton,D.F. and
Ponder,B.A.
TITLE HapMap-based study of the 17q21 ERBB2 amplicon in susceptibility to
breast cancer
JOURNAL Br. J. Cancer 95 (12), 1689-1695 (2006)
PUBMED 17117180
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 6 (residues 1 to 532)
AUTHORS Janes,P.W., Lackmann,M., Church,W.B., Sanderson,G.M.,
Sutherland,R.L. and Daly,R.J.
TITLE Structural determinants of the interaction between the erbB2
receptor and the Src homology 2 domain of Grb7
JOURNAL J. Biol. Chem. 272 (13), 8490-8497 (1997)
PUBMED 9079677
REFERENCE 7 (residues 1 to 532)
AUTHORS Tanaka,S., Mori,M., Akiyoshi,T., Tanaka,Y., Mafune,K., Wands,J.R.
and Sugimachi,K.
TITLE Coexpression of Grb7 with epidermal growth factor receptor or
Her2/erbB2 in human advanced esophageal carcinoma
JOURNAL Cancer Res. 57 (1), 28-31 (1997)
PUBMED 8988034
REFERENCE 8 (residues 1 to 532)
AUTHORS Yokote,K., Margolis,B., Heldin,C.H. and Claesson-Welsh,L.
TITLE Grb7 is a downstream signaling component of platelet-derived growth
factor alpha- and beta-receptors
JOURNAL J. Biol. Chem. 271 (48), 30942-30949 (1996)
PUBMED 8940081
REFERENCE 9 (residues 1 to 532)
AUTHORS Pandey,A., Liu,X., Dixon,J.E., Di Fiore,P.P. and Dixit,V.M.
TITLE Direct association between the Ret receptor tyrosine kinase and the
Src homology 2-containing adapter protein Grb7
JOURNAL J. Biol. Chem. 271 (18), 10607-10610 (1996)
PUBMED 8631863
REFERENCE 10 (residues 1 to 532)
AUTHORS Margolis,B., Silvennoinen,O., Comoglio,F., Roonprapunt,C.,
Skolnik,E., Ullrich,A. and Schlessinger,J.
TITLE High-efficiency expression/cloning of epidermal growth
factor-receptor-binding proteins with Src homology 2 domains
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (19), 8894-8898 (1992)
PUBMED 1409582
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC006535.2 and CR590154.1.
Summary: The product of this gene belongs to a small family of
adapter proteins that are known to interact with a number of
receptor tyrosine kinases and signaling molecules. This gene
encodes a growth factor receptor-binding protein that interacts
with epidermal growth factor receptor (EGFR) and ephrin receptors.
The protein plays a role in the integrin signaling pathway and cell
migration by binding with focal adhesion kinase (FAK). Alternative
splicing results in multiple transcript variants encoding different
isoforms, although the full-length natures of only two of the
variants have been determined to date.
Transcript Variant: This variant (2) differs in the 5' UTR compared
to variant 1. Variants 1 and 2 both encode the same protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..532
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q12"
Protein 1..532
/product="growth factor receptor-bound protein 7"
/calculated_mol_wt=59550
CDS 1..532
/gene="GRB7"
/coded_by="NM_001030002.1:107..1705"
/db_xref="CCDS:CCDS11345.1"
/db_xref="GeneID:2886"
/db_xref="HGNC:4567"
/db_xref="HPRD:03311"
/db_xref="MIM:601522"
ORIGIN
1 meldlspphl ssspedlcpa pgtppgtprp pdtplpeevk rsqplliptt grklreeerr
61 atslpsipnp fpelcsppsq spilggpssa rgllprdasr phvvkvysed gacrsvevaa
121 gatarhvcem lvqrahalsd etwglvechp hlalergled hesvvevqaa wpvggdsrfv
181 frknfakyel fkssphslfp ekmvssclda htgishedli qnflnagsfp eiqgflqlrg
241 sgrklwkrff cflrrsglyy stkgtskdpr hlqyvadvne snvyvvtqgr klygmptdfg
301 fcvkpnklrn ghkglrifcs edeqsrtcwl aafrlfkygv qlyknyqqaq srhlhpsclg
361 spplrsasdn tlvamdfsgh agrvienpre alsvaleeaq awrkktnhrl slpmpasgts
421 lsaaihrtql wfhgrisree sqrligqqgl vdglflvres qrnpqgfvls lchlqkvkhy
481 lilpseeegr lyfsmddgqt rftdllqlve fhqlnrgilp cllrhcctrv al
//