LOCUS NP_001018147 152 aa linear PRI 22-OCT-2008
DEFINITION non-metastatic cells 2, protein (NM23B) expressed in [Homo
sapiens].
ACCESSION NP_001018147
VERSION NP_001018147.1 GI:66392192
DBSOURCE REFSEQ: accession NM_001018137.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 152)
AUTHORS Tschiedel,S., Gentilini,C., Lange,T., Wolfel,C., Wolfel,T.,
Lennerz,V., Stevanovic,S., Rammensee,H.G., Huber,C., Cross,M. and
Niederwieser,D.
TITLE Identification of NM23-H2 as a tumour-associated antigen in chronic
myeloid leukaemia
JOURNAL Leukemia 22 (8), 1542-1550 (2008)
PUBMED 18496563
REMARK GeneRIF: describe the identification of NM23-H2 as a novel
HLA-A32-restricted TAA of CML cells and demonstrate the presence of
specifically reactive T cells in a patient 5 years after
transplantation
REFERENCE 2 (residues 1 to 152)
AUTHORS Hochrainer,K., Kroismayr,R., Baranyi,U., Binder,B.R. and Lipp,J.
TITLE Highly homologous HERC proteins localize to endosomes and exhibit
specific interactions with hPLIC and Nm23B
JOURNAL Cell. Mol. Life Sci. 65 (13), 2105-2117 (2008)
PUBMED 18535780
REMARK GeneRIF: While hPLIC proteins are not ubiquitinated by HERC3, HERC5
plays an important role in ubiquitination of Nm23B.
REFERENCE 3 (residues 1 to 152)
AUTHORS Rayner,K., Chen,Y.X., Hibbert,B., White,D., Miller,H., Postel,E.H.
and O'Brien,E.R.
TITLE Discovery of NM23-H2 as an estrogen receptor beta-associated
protein: role in estrogen-induced gene transcription and cell
migration
JOURNAL J. Steroid Biochem. Mol. Biol. 108 (1-2), 72-81 (2008)
PUBMED 17964137
REMARK GeneRIF: NM23-H2 as an estrogen receptor beta-associated protein
may play an important role in modulating the response to endogenous
and exogenous estrogens.
REFERENCE 4 (residues 1 to 152)
AUTHORS Kang,Y., Lee,D.C., Han,J., Yoon,S., Won,M., Yeom,J.H., Seong,M.J.,
Ko,J.J., Lee,K.A., Lee,K. and Bae,J.
TITLE NM23-H2 involves in negative regulation of Diva and Bcl2L10 in
apoptosis signaling
JOURNAL Biochem. Biophys. Res. Commun. 359 (1), 76-82 (2007)
PUBMED 17532299
REMARK GeneRIF: Thus, these results indicate the existence of a previously
undiscovered mechanism by which NM23-H2 involves in the regulation
of Diva-mediated apoptosis.
REFERENCE 5 (residues 1 to 152)
AUTHORS Ewing,R.M., Chu,P., Elisma,F., Li,H., Taylor,P., Climie,S.,
McBroom-Cerajewski,L., Robinson,M.D., O'Connor,L., Li,M.,
Taylor,R., Dharsee,M., Ho,Y., Heilbut,A., Moore,L., Zhang,S.,
Ornatsky,O., Bukhman,Y.V., Ethier,M., Sheng,Y., Vasilescu,J.,
Abu-Farha,M., Lambert,J.P., Duewel,H.S., Stewart,I.I., Kuehl,B.,
Hogue,K., Colwill,K., Gladwish,K., Muskat,B., Kinach,R.,
Adams,S.L., Moran,M.F., Morin,G.B., Topaloglou,T. and Figeys,D.
TITLE Large-scale mapping of human protein-protein interactions by mass
spectrometry
JOURNAL Mol. Syst. Biol. 3, 89 (2007)
PUBMED 17353931
REFERENCE 6 (residues 1 to 152)
AUTHORS Webb,P.A., Perisic,O., Mendola,C.E., Backer,J.M. and Williams,R.L.
TITLE The crystal structure of a human nucleoside diphosphate kinase,
NM23-H2
JOURNAL J. Mol. Biol. 251 (4), 574-587 (1995)
PUBMED 7658474
REFERENCE 7 (sites)
AUTHORS MacDonald,N.J., De la Rosa,A., Benedict,M.A., Freije,J.M.,
Krutsch,H. and Steeg,P.S.
TITLE A serine phosphorylation of Nm23, and not its nucleoside
diphosphate kinase activity, correlates with suppression of tumor
metastatic potential
JOURNAL J. Biol. Chem. 268 (34), 25780-25789 (1993)
PUBMED 8245015
REFERENCE 8 (residues 1 to 152)
AUTHORS Chandrasekharappa,S.C., Gross,L.A., King,S.E. and Collins,F.S.
TITLE The human NME2 gene lies within 18kb of NME1 in chromosome 17
JOURNAL Genes Chromosomes Cancer 6 (4), 245-248 (1993)
PUBMED 7685630
REFERENCE 9 (residues 1 to 152)
AUTHORS Gilles,A.M., Presecan,E., Vonica,A. and Lascu,I.
TITLE Nucleoside diphosphate kinase from human erythrocytes. Structural
characterization of the two polypeptide chains responsible for
heterogeneity of the hexameric enzyme
JOURNAL J. Biol. Chem. 266 (14), 8784-8789 (1991)
PUBMED 1851158
REFERENCE 10 (sites)
AUTHORS Gilles,A.M., Presecan,E., Vonica,A. and Lascu,I.
TITLE Nucleoside diphosphate kinase from human erythrocytes. Structural
characterization of the two polypeptide chains responsible for
heterogeneity of the hexameric enzyme
JOURNAL J. Biol. Chem. 266 (14), 8784-8789 (1991)
PUBMED 1851158
REFERENCE 11 (residues 1 to 152)
AUTHORS Stahl,J.A., Leone,A., Rosengard,A.M., Porter,L., King,C.R. and
Steeg,P.S.
TITLE Identification of a second human nm23 gene, nm23-H2
JOURNAL Cancer Res. 51 (1), 445-449 (1991)
PUBMED 1988104
REFERENCE 12 (residues 1 to 152)
AUTHORS Rosengard,A.M., Krutzsch,H.C., Shearn,A., Biggs,J.R., Barker,E.,
Margulies,I.M., King,C.R., Liotta,L.A. and Steeg,P.S.
TITLE Reduced Nm23/Awd protein in tumour metastasis and aberrant
Drosophila development
JOURNAL Nature 342 (6246), 177-180 (1989)
PUBMED 2509941
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
CK023920.1, M36981.1 and BC002476.2.
Summary: Nucleoside diphosphate kinase (NDK) exists as a hexamer
composed of 'A' (encoded by NME1) and 'B' (encoded by this gene)
isoforms. Multiple alternatively spliced transcript variants
encoding the same isoform have been found for this gene.
Co-transcription of this gene and the neighboring upstream gene
(NME1) generates naturally-occurring transcripts (NME1-NME2) which
encode a fusion protein comprised of sequence sharing identity with
each individual gene product. [provided by RefSeq].
Transcript Variant: This variant (2) differs in the 5' UTR,
compared to variant 1. All variants encode the same protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..152
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q21.3"
Protein 1..152
/product="non-metastatic cells 2, protein (NM23B)
expressed in"
/EC_number="2.7.4.6"
/note="non-metastatic cells 2, protein (NM23) expressed
in; NDP kinase B; c-myc transcription factor"
/calculated_mol_wt=17167
Site 44
/site_type="phosphorylation"
/experiment="experimental evidence, no additional details
recorded"
/citation=[7]
/db_xref="HPRD:01132"
Site 118
/site_type="phosphorylation"
/experiment="experimental evidence, no additional details
recorded"
/citation=[9]
/db_xref="HPRD:01132"
CDS 1..152
/gene="NME2"
/gene_synonym="puf"
/gene_synonym="NDPKB"
/gene_synonym="NM23B"
/gene_synonym="NDPK-B"
/gene_synonym="NM23-H2"
/gene_synonym="MGC111212"
/coded_by="NM_001018137.1:157..615"
/db_xref="CCDS:CCDS11580.1"
/db_xref="GeneID:4831"
/db_xref="HGNC:7850"
/db_xref="HPRD:01132"
/db_xref="MIM:156491"
ORIGIN
1 manlertfia ikpdgvqrgl vgeiikrfeq kgfrlvamkf lraseehlkq hyidlkdrpf
61 fpglvkymns gpvvamvweg lnvvktgrvm lgetnpadsk pgtirgdfci qvgrniihgs
121 dsvksaekei slwfkpeelv dykscahdwv ye
//