LOCUS       NP_001018146             267 aa            linear   PRI 19-SEP-2008
DEFINITION  NME1-NME2 protein [Homo sapiens].
ACCESSION   NP_001018146
VERSION     NP_001018146.1  GI:66392203
DBSOURCE    REFSEQ: accession NM_001018136.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 267)
  AUTHORS   Valentijn,L.J., Koster,J. and Versteeg,R.
  TITLE     Read-through transcript from NM23-H1 into the neighboring NM23-H2
            gene encodes a novel protein, NM23-LV
  JOURNAL   Genomics 87 (4), 483-489 (2006)
   PUBMED   16442775
REFERENCE   2  (sites)
  AUTHORS   MacDonald,N.J., De la Rosa,A., Benedict,M.A., Freije,J.M.,
            Krutsch,H. and Steeg,P.S.
  TITLE     A serine phosphorylation of Nm23, and not its nucleoside
            diphosphate kinase activity, correlates with suppression of tumor
            metastatic potential
  JOURNAL   J. Biol. Chem. 268 (34), 25780-25789 (1993)
   PUBMED   8245015
REFERENCE   3  (sites)
  AUTHORS   Gilles,A.M., Presecan,E., Vonica,A. and Lascu,I.
  TITLE     Nucleoside diphosphate kinase from human erythrocytes. Structural
            characterization of the two polypeptide chains responsible for
            heterogeneity of the hexameric enzyme
  JOURNAL   J. Biol. Chem. 266 (14), 8784-8789 (1991)
   PUBMED   1851158
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI603164.1, BG388883.1 and BC002476.2.
            
            Summary: The NME1-NME2 mRNA is a naturally occurring co-transcribed
            product of the neighboring NME1 and NME2 genes. The significance of
            this co-transcribed mRNA and the function of its predicted protein
            product have not yet been determined. Alternative splicing of this
            gene results in different transcript variants encoding distinct
            isoforms, but the full-length nature of each variant has not been
            defined. [provided by RefSeq].
FEATURES             Location/Qualifiers
     source          1..267
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.3"
     Protein         1..267
                     /product="NME1-NME2 protein"
                     /note="NM23-LV"
                     /calculated_mol_wt=30006
     Site            159
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /citation=[2]
                     /db_xref="HPRD:01132"
     Site            233
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /citation=[3]
                     /db_xref="HPRD:01132"
     CDS             1..267
                     /gene="NME1-NME2"
                     /gene_synonym="NME2"
                     /coded_by="NM_001018136.1:109..912"
                     /db_xref="CCDS:CCDS32682.1"
                     /db_xref="GeneID:654364"
                     /db_xref="HGNC:33531"
                     /db_xref="HPRD:01132"
ORIGIN      
        1 mancertfia ikpdgvqrgl vgeiikrfeq kgfrlvglkf mqasedllke hyvdlkdrpf
       61 faglvkymhs gpvvamvweg lnvvktgrvm lgetnpadsk pgtirgdfci qvgrtmanle
      121 rtfiaikpdg vqrglvgeii krfeqkgfrl vamkflrase ehlkqhyidl kdrpffpglv
      181 kymnsgpvva mvweglnvvk tgrvmlgetn padskpgtir gdfciqvgrn iihgsdsvks
      241 aekeislwfk peelvdyksc ahdwvye
//