LOCUS NP_001017915 1189 aa linear PRI 10-FEB-2008
DEFINITION SH2 containing inositol phosphatase isoform a [Homo sapiens].
ACCESSION NP_001017915
VERSION NP_001017915.1 GI:64085167
DBSOURCE REFSEQ: accession NM_001017915.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 1189)
AUTHORS Gilby,D.C., Goodeve,A.C., Winship,P.R., Valk,P.J., Delwel,R. and
Reilly,J.T.
TITLE Gene structure, expression profiling and mutation analysis of the
tumour suppressor SHIP1 in Caucasian acute myeloid leukaemia
JOURNAL Leukemia 21 (11), 2390-2393 (2007)
PUBMED 17657219
REMARK GeneRIF: Gene structure, expression profiling and mutation analysis
of the tumour suppressor SHIP1 in Caucasian acute myeloid leukaemia
REFERENCE 2 (residues 1 to 1189)
AUTHORS Gloire,G., Erneux,C. and Piette,J.
TITLE The role of SHIP1 in T-lymphocyte life and death
JOURNAL Biochem. Soc. Trans. 35 (PT 2), 277-280 (2007)
PUBMED 17371259
REMARK GeneRIF: SHIP1 not only acts as a negative player in T-cell lines
proliferation, but also regulates critical pathways, such as
NF-kappaB (nuclear factor kappaB) activation.
REFERENCE 3 (residues 1 to 1189)
AUTHORS Vaillancourt,M., Levasseur,S., Tremblay,M.L., Marois,L.,
Rollet-Labelle,E. and Naccache,P.H.
TITLE The Src homology 2-containing inositol 5-phosphatase 1 (SHIP1) is
involved in CD32a signaling in human neutrophils
JOURNAL Cell. Signal. 18 (11), 2022-2032 (2006)
PUBMED 16682172
REMARK GeneRIF: Our results indicate that SHIP1 is involved, in a Src
kinase-dependent manner, in the early signaling events observed
upon the cross-linking of CD32a in human neutrophils.
REFERENCE 4 (residues 1 to 1189)
AUTHORS Gloire,G., Charlier,E., Rahmouni,S., Volanti,C., Chariot,A.,
Erneux,C. and Piette,J.
TITLE Restoration of SHIP-1 activity in human leukemic cells modifies
NF-kappaB activation pathway and cellular survival upon oxidative
stress
JOURNAL Oncogene 25 (40), 5485-5494 (2006)
PUBMED 16619039
REMARK GeneRIF: Study showed H2O2-induced IKK activation in leukemic cells
is mediated by SHIP-1; Jurkat cells expressing SHIP-1 are more
resistant to H2O2-induced apoptosis than parental cells, suggesting
SHIP-1 has an important role in leukemic cell responses to ROS
REFERENCE 5 (residues 1 to 1189)
AUTHORS MacGlashan,D. Jr. and Vilarino,N.
TITLE Nonspecific desensitization, functional memory, and the
characteristics of SHIP phosphorylation following IgE-mediated
stimulation of human basophils
JOURNAL J. Immunol. 177 (2), 1040-1051 (2006)
PUBMED 16818760
REMARK GeneRIF: SHIP phosphorylation in stimulated human basophils
undergoes modest nonspecific desensitization that persists despite
dissociation of the desensitizing antigen, resulting in an
immunologic memory of prior stimulation.
REFERENCE 6 (residues 1 to 1189)
AUTHORS Ware,M.D., Rosten,P., Damen,J.E., Liu,L., Humphries,R.K. and
Krystal,G.
TITLE Cloning and characterization of human SHIP, the 145-kD inositol
5-phosphatase that associates with SHC after cytokine stimulation
JOURNAL Blood 88 (8), 2833-2840 (1996)
PUBMED 8874179
REFERENCE 7 (residues 1 to 1189)
AUTHORS Drayer,A.L., Pesesse,X., De Smedt,F., Woscholski,R., Parker,P. and
Erneux,C.
TITLE Cloning and expression of a human placenta inositol
1,3,4,5-tetrakisphosphate and phosphatidylinositol
3,4,5-trisphosphate 5-phosphatase
JOURNAL Biochem. Biophys. Res. Commun. 225 (1), 243-249 (1996)
PUBMED 8769125
REFERENCE 8 (residues 1 to 1189)
AUTHORS Lioubin,M.N., Algate,P.A., Tsai,S., Carlberg,K., Aebersold,A. and
Rohrschneider,L.R.
TITLE p150Ship, a signal transduction molecule with inositol
polyphosphate-5-phosphatase activity
JOURNAL Genes Dev. 10 (9), 1084-1095 (1996)
PUBMED 8654924
REFERENCE 9 (residues 1 to 1189)
AUTHORS Kavanaugh,W.M., Pot,D.A., Chin,S.M., Deuter-Reinhard,M.,
Jefferson,A.B., Norris,F.A., Masiarz,F.R., Cousens,L.S.,
Majerus,P.W. and Williams,L.T.
TITLE Multiple forms of an inositol polyphosphate 5-phosphatase form
signaling complexes with Shc and Grb2
JOURNAL Curr. Biol. 6 (4), 438-445 (1996)
PUBMED 8723348
REFERENCE 10 (residues 1 to 1189)
AUTHORS Damen,J.E., Liu,L., Rosten,P., Humphries,R.K., Jefferson,A.B.,
Majerus,P.W. and Krystal,G.
TITLE The 145-kDa protein induced to associate with Shc by multiple
cytokines is an inositol tetraphosphate and phosphatidylinositol
3,4,5-triphosphate 5-phosphatase
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (4), 1689-1693 (1996)
PUBMED 8643691
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BE247227.1, BM800110.1,
U84400.1, U50040.1 and BC062985.1.
Summary: This gene is a member of the inositol
polyphosphate-5-phosphatase (INPP5) family and encodes a protein
with an N-terminal SH2 domain, an inositol phosphatase domain, and
two C-terminal protein interaction domains. Expression of this
protein is restricted to hematopoietic cells where its movement
from the cytosol to the plasma membrane is mediated by tyrosine
phosphorylation. At the plasma membrane, the protein hydrolyzes the
5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and
inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple
signaling pathways. Overall, the protein functions as a negative
regulator of myeliod cell proliferation and survival. Alternate
transcriptional splice variants, encoding different isoforms, have
been characterized.
Transcript Variant: This variant (1) represents the longer
transcript and encodes the longer isoform (a).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..1189
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q37.1"
Protein 1..1189
/product="SH2 containing inositol phosphatase isoform a"
/note="p150Ship; signaling inositol polyphosphate 5
phosphatase SIP-145; SH2 containing inositol phosphatase,
isoform b"
/calculated_mol_wt=133162
CDS 1..1189
/gene="INPP5D"
/gene_synonym="SHIP"
/gene_synonym="SHIP1"
/gene_synonym="hp51CN"
/gene_synonym="SIP-145"
/gene_synonym="MGC104855"
/gene_synonym="MGC142140"
/gene_synonym="MGC142142"
/coded_by="NM_001017915.1:154..3723"
/note="isoform a is encoded by transcript variant 1"
/db_xref="GeneID:3635"
/db_xref="HGNC:6079"
/db_xref="MIM:601582"
ORIGIN
1 mvpcwnhgni trskaeells rtgkdgsflv rasesisray alcvlyrncv ytyrilpned
61 dkftvqaseg vsmrfftkld qliefykken mglvthlqyp vpleeedtgd dpeedtvesv
121 vsppelpprn ipltasscea kevpfsnenp ratetsrpsl setlfqrlqs mdtsglpeeh
181 lkaiqdylst qlaqdsefvk tgssslphlk klttllckel ygevirtlps leslqrlfdq
241 qlspglrprp qvpgeanpin mvsklsqlts llssiedkvk allhegpesp hrpslippvt
301 fevkaeslgi pqkmqlkvdv esgkliikks kdgsedkfys hkkilqliks qkflnklvil
361 vetekekilr keyvfadskk regfcqllqq mknkhseqpe pdmitifigt wnmgnapppk
421 kitswflskg qgktrddsad yiphdiyvig tqedplseke wleilkhslq eitsvtfktv
481 aihtlwniri vvlakpehen rishictdnv ktgiantlgn kgavgvsfmf ngtslgfvns
541 hltsgsekkl rrnqnymnil rflalgdkkl spfnithrft hlfwfgdlny rvdlptweae
601 tiiqkikqqq yadllshdql lterreqkvf lhfeeeeitf aptyrferlt rdkyaytkqk
661 atgmkynlps wcdrvlwksy plvhvvcqsy gstsdimtsd hspvfatfea gvtsqfvskn
721 gpgtvdsqgq ieflrcyatl ktksqtkfyl efhssclesf vksqegenee gsegelvvkf
781 getlpklkpi isdpeylldq hilisikssd sdesygegci alrleatetq lpiytplthh
841 geltghfqge iklqtsqgkt reklydfvkt erdessgpkt lksltshdpm kqwevtsrap
901 pcsgssitei inpnymgvgp fgppmplhvk qtlspdqqpt awsydqppkd splgpcrges
961 pptppgqppi spkkflpsta nrglpprtqe srpsdlgkna gdtlpqedlp ltkpemfenp
1021 lygslssfpk paprkdqesp kmprkepppc pepgilspsi vltkaqeadr gegpgkqvpa
1081 prlrsftcss saegraaggd ksqgkpktpv ssqapvpakr pikpsrsein qqtpptptpr
1141 pplpvkspav lhlqhskgrd yrdntelphh gkhrpeegpp gplgrtamq
//