LOCUS       NP_001017461            1023 aa            linear   ROD 12-OCT-2008
DEFINITION  oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
            [Rattus norvegicus].
ACCESSION   NP_001017461 XP_573650
VERSION     NP_001017461.1  GI:62945278
DBSOURCE    REFSEQ: accession NM_001017461.1
KEYWORDS    .
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
            Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1023)
  AUTHORS   Starkov,A.A., Fiskum,G., Chinopoulos,C., Lorenzo,B.J., Browne,S.E.,
            Patel,M.S. and Beal,M.F.
  TITLE     Mitochondrial alpha-ketoglutarate dehydrogenase complex generates
            reactive oxygen species
  JOURNAL   J. Neurosci. 24 (36), 7779-7788 (2004)
   PUBMED   15356189
  REMARK    GeneRIF: Alpha-ketoglutarate dehydrogenase is a primary site of ROS
            production in normally functioning mitochondria.
REFERENCE   2  (residues 1 to 1023)
  AUTHORS   Bruschi,S.A., Lindsay,J.G. and Crabb,J.W.
  TITLE     Mitochondrial stress protein recognition of inactivated
            dehydrogenases during mammalian cell death
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 95 (23), 13413-13418 (1998)
   PUBMED   9811814
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083811.1.
            On Apr 29, 2005 this sequence version replaced gi:62660772.
FEATURES             Location/Qualifiers
     source          1..1023
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     Protein         1..1023
                     /product="oxoglutarate (alpha-ketoglutarate) dehydrogenase
                     (lipoamide)"
                     /EC_number="1.2.4.2"
                     /note="oxoglutarate dehydrogenase (lipoamide)"
                     /calculated_mol_wt=116165
     CDS             1..1023
                     /gene="Ogdh"
                     /coded_by="NM_001017461.1:79..3150"
                     /db_xref="GeneID:360975"
                     /db_xref="RGD:1561359"
ORIGIN      
        1 mfhlrtcaak lrpltasqtv ktfsqnkpaa irtfqqircy sapvaaepfl sgtssnyvee
       61 mycawlenpk svhkswdiff rntnagappg tayqsplsls rsslatmaha qslveaqpnv
      121 dklvedhlav qslirayqir ghhvaqldpl gildadldss vpadiisstd klgfyglhes
      181 dldkvfhlpt ttfiggqepa lplreiirrl emaycqhigv efmfindleq cqwirqkfet
      241 pgimqftnee krtllarlvr strfeeflqr kwssekrfgl egcevlipal ktiidmssan
      301 gvdyvimgmp hrgrlnvlan virkeleqif cqfdskleaa degsgdmkyh lgmyhrrinr
      361 vtdrnitlsl vanpshleaa dpvvmgktka eqfycgdteg kkvmsillhg daafagqgiv
      421 yetfhlsdlp sytthgtvhv vvnnqigftt dprmarsspy ptdvarvvna pifhvnsddp
      481 eavmyvckva aewrntfhkd vvvdlvcyrr nghnemdepm ftqplmykqi rkqkpvlqky
      541 aellvsqgvv nqpeyeeeis kydkiceeaf trskdekilh ikhwldspwp gfftldgqpr
      601 smtcpstgle edilthignv assvpvenft ihgglsrilk trrelvtnrt vdwalaeyma
      661 fgsllkegih vrlsgqdver gtfshrhhvl hdqnvdkrtc ipmnhlwpnq apytvcnssl
      721 seygvlgfel gfamaspnal vlweaqfgdf nnmaqciidq ficpgqakwv rqngivlllp
      781 hgmegmgpeh ssarperflq mcnddpdvlp nlqeenfdis qlydcnwivv ncstpgnffh
      841 vlrrqillpf rkplivftpk sllrhpeart sfdemlpgth fqrvipedgp aaqnpdkvkr
      901 llfctgkvyy dltrerkard maeevaitri eqlspfpfdl llkeaqkypn aelawcqeeh
      961 knqgyydyvk prlrttidra kpvwyagrdp aaapatgnkk thltelqrfl dtafdldafk
     1021 kfs
//