LOCUS NP_001015001 417 aa linear PRI 22-OCT-2008
DEFINITION creatine kinase, mitochondrial 1A precursor [Homo sapiens].
ACCESSION NP_001015001
VERSION NP_001015001.1 GI:66346730
DBSOURCE REFSEQ: accession NM_001015001.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 417)
AUTHORS Epand,R.F., Schlattner,U., Wallimann,T., Lacombe,M.L. and
Epand,R.M.
TITLE Novel lipid transfer property of two mitochondrial proteins that
bridge the inner and outer membranes
JOURNAL Biophys. J. 92 (1), 126-137 (2007)
PUBMED 17028143
REMARK GeneRIF: MtCK, but not NDPK-D, shows some specificity in the nature
of the lipids transferred and it is not active with
phosphatidylcholine alone
REFERENCE 2 (residues 1 to 417)
AUTHORS Wendt,S., Schlattner,U. and Wallimann,T.
TITLE Differential effects of peroxynitrite on human mitochondrial
creatine kinase isoenzymes. Inactivation, octamer destabilization,
and identification of involved residues
JOURNAL J. Biol. Chem. 278 (2), 1125-1130 (2003)
PUBMED 12401781
REFERENCE 3 (residues 1 to 417)
AUTHORS Schlattner,U., Mockli,N., Speer,O., Werner,S. and Wallimann,T.
TITLE Creatine kinase and creatine transporter in normal, wounded, and
diseased skin
JOURNAL J. Invest. Dermatol. 118 (3), 416-423 (2002)
PUBMED 11874479
REFERENCE 4 (residues 1 to 417)
AUTHORS Schlattner,U., Dolder,M., Wallimann,T. and Tokarska-Schlattner,M.
TITLE Mitochondrial creatine kinase and mitochondrial outer membrane
porin show a direct interaction that is modulated by calcium
JOURNAL J. Biol. Chem. 276 (51), 48027-48030 (2001)
PUBMED 11602586
REFERENCE 5 (residues 1 to 417)
AUTHORS Schlattner,U. and Wallimann,T.
TITLE A quantitative approach to membrane binding of human ubiquitous
mitochondrial creatine kinase using surface plasmon resonance
JOURNAL J. Bioenerg. Biomembr. 32 (1), 123-131 (2000)
PUBMED 11768757
REFERENCE 6 (residues 1 to 417)
AUTHORS Brdiczka,D., Kaldis,P. and Wallimann,T.
TITLE In vitro complex formation between the octamer of mitochondrial
creatine kinase and porin
JOURNAL J. Biol. Chem. 269 (44), 27640-27644 (1994)
PUBMED 7525559
REFERENCE 7 (residues 1 to 417)
AUTHORS Haas,R.C. and Strauss,A.W.
TITLE Separate nuclear genes encode sarcomere-specific and ubiquitous
human mitochondrial creatine kinase isoenzymes
JOURNAL J. Biol. Chem. 265 (12), 6921-6927 (1990)
PUBMED 2324105
REFERENCE 8 (residues 1 to 417)
AUTHORS Haas,R.C., Korenfeld,C., Zhang,Z.F., Perryman,B., Roman,D. and
Strauss,A.W.
TITLE Isolation and characterization of the gene and cDNA encoding human
mitochondrial creatine kinase
JOURNAL J. Biol. Chem. 264 (5), 2890-2897 (1989)
PUBMED 2914937
REMARK Erratum:[J Biol Chem 1989 Sep 25;264(27):16332]
REFERENCE 9 (residues 1 to 417)
AUTHORS Stallings,R.L., Olson,E., Strauss,A.W., Thompson,L.H.,
Bachinski,L.L. and Siciliano,M.J.
TITLE Human creatine kinase genes on chromosomes 15 and 19, and proximity
of the gene for the muscle form to the genes for apolipoprotein C2
and excision repair
JOURNAL Am. J. Hum. Genet. 43 (2), 144-151 (1988)
PUBMED 3400641
REFERENCE 10 (residues 1 to 417)
AUTHORS Jacobus,W.E., Moreadith,R.W. and Vandegaer,K.M.
TITLE Control of heart oxidative phosphorylation by creatine kinase in
mitochondrial membranes
JOURNAL Ann. N. Y. Acad. Sci. 414, 73-89 (1983)
PUBMED 6584077
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BM923431.1 and BC006467.1.
Summary: Mitochondrial creatine (MtCK) kinase is responsible for
the transfer of high energy phosphate from mitochondria to the
cytosolic carrier, creatine. It belongs to the creatine kinase
isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and
ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine
kinase occurs in two different oligomeric forms: dimers and
octamers, in contrast to the exclusively dimeric cytosolic creatine
kinase isoenzymes. Many malignant cancers with poor prognosis have
shown overexpression of ubiquitous mitochondrial creatine kinase;
this may be related to high energy turnover and failure to
eliminate cancer cells via apoptosis. Ubiquitous mitochondrial
creatine kinase has 80% homology with the coding exons of
sarcomeric mitochondrial creatine kinase. Two genes located near
each other on chromosome 15 have been identified which encode
identical mitochondrial creatine kinase proteins. [provided by
RefSeq].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..417
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="15"
/map="15q15"
Protein 1..417
/product="creatine kinase, mitochondrial 1A precursor"
/EC_number="2.7.3.2"
/note="creatine kinase, mitochondrial 1 (ubiquitous);
acidic-type mitochondrial creatine kinase"
transit_peptide 1..39
/calculated_mol_wt=3975
mat_peptide 40..417
/product="creatine kinase, mitochondrial 1A"
/calculated_mol_wt=43080
CDS 1..417
/gene="CKMT1A"
/gene_synonym="CKMT1"
/gene_synonym="UMTCK"
/gene_synonym="FLJ50967"
/coded_by="NM_001015001.1:393..1646"
/db_xref="CCDS:CCDS32217.1"
/db_xref="GeneID:548596"
/db_xref="HGNC:31736"
/db_xref="HPRD:18683"
ORIGIN
1 magpfsrlls arpglrllal agagslaagf llrpepvraa serrrlypps aeypdlrkhn
61 ncmashltpa vyarlcdktt ptgwtldqci qtgvdnpghp fiktvgmvag deetyevfad
121 lfdpviqerh ngydprtmkh ttdldaskir sgyfderyvl ssrvrtgrsi rglslppact
181 raerreverv vvdalsglkg dlagryyrls emteaeqqql iddhflfdkp vsplltaagm
241 ardwpdargi whnneksfli wvneedhtrv ismekggnmk rvferfcrgl keverliqer
301 gwefmwnerl gyiltcpsnl gtglragvhi klpllskdsr fpkilenlrl qkrgtggvdt
361 aatggvfdis nldrlgksev elvqlvidgv nylidcerrl ergqdiript pvihtkh
//