LOCUS NP_001012530 141 aa linear PRI 10-AUG-2008
DEFINITION gastrin-releasing peptide isoform 2 preproprotein [Homo sapiens].
ACCESSION NP_001012530
VERSION NP_001012530.1 GI:60498997
DBSOURCE REFSEQ: accession NM_001012512.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 141)
AUTHORS Hodges,L.M., Weissman,M.M., Haghighi,F., Costa,R., Bravo,O.,
Evgrafov,O., Knowles,J.A., Fyer,A.J. and Hamilton,S.P.
TITLE Association and linkage analysis of candidate genes GRP, GRPR,
CRHR1, and TACR1 in panic disorder
JOURNAL Am. J. Med. Genet. B Neuropsychiatr. Genet. (2008) In press
PUBMED 18452185
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
Publication Status: Available-Online prior to print
REFERENCE 2 (residues 1 to 141)
AUTHORS Grimsholm,O., Rantapaa-Dahlqvist,S., Dalen,T. and Forsgren,S.
TITLE Observations favouring the occurrence of local production and
marked effects of bombesin/gastrin-releasing peptide in the
synovial tissue of the human knee joint--comparisons with substance
P and the NK-1 receptor
JOURNAL Neuropeptides 42 (2), 133-145 (2008)
PUBMED 18289674
REMARK GeneRIF: BN/GRP is produced by non-neuronal cells in the synovial
tissue in rheumatoid and osteoarthritis
REFERENCE 3 (residues 1 to 141)
AUTHORS Taglia,L., Matusiak,D. and Benya,R.V.
TITLE GRP-induced up-regulation of Hsp72 promotes CD16+/94+ natural
killer cell binding to colon cancer cells causing tumor cell
cytolysis
JOURNAL Clin. Exp. Metastasis 25 (4), 451-463 (2008)
PUBMED 18350254
REMARK GeneRIF: GRP-induced up-regulation of Hsp72 promotes CD16+/94+
natural killer cell binding to colon cancer cells causing tumor
cell cytolysis.
REFERENCE 4 (residues 1 to 141)
AUTHORS Corral,R.S., Iniguez,M.A., Duque,J., Lopez-Perez,R. and Fresno,M.
TITLE Bombesin induces cyclooxygenase-2 expression through the activation
of the nuclear factor of activated T cells and enhances cell
migration in Caco-2 colon carcinoma cells
JOURNAL Oncogene 26 (7), 958-969 (2007)
PUBMED 16909108
REMARK GeneRIF: First evidence is provided that the
calcium-ion/calcineurin/NFAT-linked pathway is involved in
bombesin-mediated induction of Cox-2, a gene that promotes colon
carcinoma invasiveness.
REFERENCE 5 (residues 1 to 141)
AUTHORS Taglia,L., Matusiak,D., Matkowskyj,K.A. and Benya,R.V.
TITLE Gastrin-releasing peptide mediates its morphogenic properties in
human colon cancer by upregulating intracellular adhesion protein-1
(ICAM-1) via focal adhesion kinase
JOURNAL Am. J. Physiol. Gastrointest. Liver Physiol. 292 (1), G182-G190
(2007)
PUBMED 16920698
REMARK GeneRIF: GRP upregulation of ICAM-1 via FAK promotes tumor cell
motility and attachment to the extracellular matrix.
REFERENCE 6 (residues 1 to 141)
AUTHORS Baraniuk,J.N., Lundgren,J.D., Shelhamer,J.H. and Kaliner,M.A.
TITLE Gastrin releasing peptide (GRP) binding sites in human bronchi
JOURNAL Neuropeptides 21 (2), 81-84 (1992)
PUBMED 1557184
REFERENCE 7 (residues 1 to 141)
AUTHORS Naylor,S.L., Sakaguchi,A.Y., Spindel,E. and Chin,W.W.
TITLE Human gastrin-releasing peptide gene is located on chromosome 18
JOURNAL Somat. Cell Mol. Genet. 13 (1), 87-91 (1987)
PUBMED 3027902
REFERENCE 8 (residues 1 to 141)
AUTHORS Lebacq-Verheyden,A.M., Bertness,V., Kirsch,I., Hollis,G.F.,
McBride,O.W. and Battey,J.
TITLE Human gastrin-releasing peptide gene maps to chromosome band 18q21
JOURNAL Somat. Cell Mol. Genet. 13 (1), 81-86 (1987)
PUBMED 3027901
REFERENCE 9 (residues 1 to 141)
AUTHORS Sausville,E.A., Lebacq-Verheyden,A.M., Spindel,E.R., Cuttitta,F.,
Gazdar,A.F. and Battey,J.F.
TITLE Expression of the gastrin-releasing peptide gene in human small
cell lung cancer. Evidence for alternative processing resulting in
three distinct mRNAs
JOURNAL J. Biol. Chem. 261 (5), 2451-2457 (1986)
PUBMED 3003116
REFERENCE 10 (residues 1 to 141)
AUTHORS Spindel,E.R., Zilberberg,M.D., Habener,J.F. and Chin,W.W.
TITLE Two prohormones for gastrin-releasing peptide are encoded by two
mRNAs differing by 19 nucleotides
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 83 (1), 19-23 (1986)
PUBMED 3001723
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC004488.2 and W01859.1.
Summary: This gene encodes a member of the bombesin-like family of
gastrin-releasing peptides. Its preproprotein, following cleavage
of a signal peptide, is further processed to produce either the 27
aa gastrin-releasing peptide or the 10 aa neuromedin C. These
smaller peptides regulate numerous functions of the
gastrointestinal and central nervous systems, including release of
gastrointestinal hormones, smooth muscle cell contraction, and
epithelial cell proliferation. These peptides are also likely to
play a role in human cancers of the lung, colon, stomach, pancreas,
breast, and prostate. Alternative splicing results in multiple
transcript variants encoding different isoforms. [provided by
RefSeq].
Transcript Variant: This variant (2) uses an alternate in-frame
splice site in the 3' coding region, compared to variant 1,
resulting in a shorter protein (isoform 2). This variant has also
been identified as 'splice isoform 3' and 'pro-gastrin releasing
peptide type 2'.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..141
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="18"
/map="18q21.1-q21.32"
Protein 1..141
/product="gastrin-releasing peptide isoform 2
preproprotein"
/note="bombesin; neuromedin C; pre-progastrin releasing
peptide"
sig_peptide 1..23
/calculated_mol_wt=2518
proprotein 24..141
/product="gastrin-releasing peptide proprotein"
/calculated_mol_wt=13033
mat_peptide 24..50
/product="gastrin-releasing peptide"
/calculated_mol_wt=2860
mat_peptide 41..50
/product="neuromedin C"
/exception="alternative processing"
/calculated_mol_wt=1121
CDS 1..141
/gene="GRP"
/gene_synonym="BN"
/gene_synonym="GRP-10"
/gene_synonym="proGRP"
/gene_synonym="preproGRP"
/coded_by="NM_001012512.1:99..524"
/note="isoform 2 preproprotein is encoded by transcript
variant 2"
/db_xref="GeneID:2922"
/db_xref="HGNC:4605"
/db_xref="MIM:137260"
ORIGIN
1 mrgrelplvl lalvlclapr gravplpagg gtvltkmypr gnhwavghlm gkkstgesss
61 vsergslkqq lreyirweea arnllgliea kenrnhqppq pkalgnqqps wdsedssnfk
121 dvgskgkgsq regrnpqlnq q
//