LOCUS       NP_001010969             519 aa            linear   PRI 22-OCT-2008
DEFINITION  cytochrome P450, family 4, subfamily A, polypeptide 22 [Homo
            sapiens].
ACCESSION   NP_001010969 XP_208213
VERSION     NP_001010969.2  GI:62952506
DBSOURCE    REFSEQ: accession NM_001010969.2
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 519)
  AUTHORS   Gainer,J.V., Bellamine,A., Dawson,E.P., Womble,K.E., Grant,S.W.,
            Wang,Y., Cupples,L.A., Guo,C.Y., Demissie,S., O'Donnell,C.J.,
            Brown,N.J., Waterman,M.R. and Capdevila,J.H.
  TITLE     Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid
            synthase is associated with essential hypertension
  JOURNAL   Circulation 111 (1), 63-69 (2005)
   PUBMED   15611369
REFERENCE   2  (residues 1 to 519)
  AUTHORS   Nelson,D.R., Zeldin,D.C., Hoffman,S.M., Maltais,L.J., Wain,H.M. and
            Nebert,D.W.
  TITLE     Comparison of cytochrome P450 (CYP) genes from the mouse and human
            genomes, including nomenclature recommendations for genes,
            pseudogenes and alternative-splice variants
  JOURNAL   Pharmacogenetics 14 (1), 1-18 (2004)
   PUBMED   15128046
  REMARK    Review article
REFERENCE   3  (residues 1 to 519)
  AUTHORS   Bellamine,A., Wang,Y., Waterman,M.R., Gainer,J.V. III, Dawson,E.P.,
            Brown,N.J. and Capdevila,J.H.
  TITLE     Characterization of the CYP4A11 gene, a second CYP4A gene in humans
  JOURNAL   Arch. Biochem. Biophys. 409 (1), 221-227 (2003)
   PUBMED   12464262
  REMARK    Erratum:[Arch Biochem Biophys. 2003 Apr 1;412(1):153]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL135960.1.
            On Apr 28, 2005 this sequence version replaced gi:58293787.
            
            Summary: This gene encodes a member of the cytochrome P450
            superfamily of enzymes. The cytochrome P450 proteins are
            monooxygenases which catalyze many reactions involved in drug
            metabolism and synthesis of cholesterol, steroids and other lipids.
            This gene is part of a cluster of cytochrome P450 genes on
            chromosome 1p33. [provided by RefSeq].
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p33"
     Protein         1..519
                     /product="cytochrome P450, family 4, subfamily A,
                     polypeptide 22"
                     /EC_number="1.14.15.3"
                     /note="cytochrome P450 4A22K"
                     /calculated_mol_wt=59115
     Site            457
                     /site_type="binding"
                     /note="heme binding site"
     CDS             1..519
                     /gene="CYP4A22"
                     /coded_by="NM_001010969.2:52..1611"
                     /db_xref="CCDS:CCDS30707.1"
                     /db_xref="GeneID:284541"
                     /db_xref="HGNC:20575"
                     /db_xref="HPRD:16776"
ORIGIN      
        1 msvsvlspsr rlggvsgilq vtsllillll likaaqlylh rqwllkalqq fpcppshwlf
       61 ghiqefqhdq elqriqervk tfpsacpywi wggkvrvqly dpdymkvilg rsdpkshgsy
      121 kflaprigyg llllngqtwf qhrrmltpaf hndilkpyvg lmadsvrvml dkweellgqd
      181 splevfqhvs lmtldtimks afshqgsiqv drnsqsyiqa isdlnslvfc cmrnafhend
      241 tiysltsagr wthracqlah qhtdqviqlr kaqlqkegel ekikrkrhld fldilllakm
      301 engsilsdkd lraevdtfmf eghdttasgi swilyalath pkhqercree ihgllgdgas
      361 itwnhldqmp yttmcikeal rlyppvpgig relstpvtfp dgrslpkgim vllsiyglhh
      421 npkvwpnlev fdpsrfapgs aqhshaflpf sggsrncigk qfamnqlkva raltllrfel
      481 lpdptripip marlvlkskn gihlrlrrlp npcedkdql
//