LOCUS       NP_001009467             483 aa            linear   MAM 22-OCT-2008
DEFINITION  phosphogluconate dehydrogenase [Ovis aries].
ACCESSION   NP_001009467
VERSION     NP_001009467.1  GI:57164179
DBSOURCE    REFSEQ: accession NM_001009467.2
KEYWORDS    .
SOURCE      Ovis aries (sheep)
  ORGANISM  Ovis aries
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
            Pecora; Bovidae; Caprinae; Ovis.
REFERENCE   1  (residues 1 to 483)
  AUTHORS   Cervellati,C., Dallocchio,F., Bergamini,C.M. and Cook,P.F.
  TITLE     Role of methionine-13 in the catalytic mechanism of
            6-phosphogluconate dehydrogenase from sheep liver
  JOURNAL   Biochemistry 44 (7), 2432-2440 (2005)
   PUBMED   15709755
  REMARK    GeneRIF: Methionine at position 13 plays a significant role in
            orienting the cofactor nicotinamide ring with respect to geometry
            and distance, thereby optimizing the geometry for hydride transfer,
            and perhaps the decarboxylation step in the 6PGDH reaction.
REFERENCE   2  (residues 1 to 483)
  AUTHORS   Phillips,C., Gover,S. and Adams,M.J.
  TITLE     Structure of 6-phosphogluconate dehydrogenase refined at 2 A
            resolution
  JOURNAL   Acta Crystallogr. D Biol. Crystallogr. 51 (PT 3), 290-304 (1995)
   PUBMED   15299295
REFERENCE   3  (residues 1 to 483)
  AUTHORS   Adams,M.J., Ellis,G.H., Gover,S., Naylor,C.E. and Phillips,C.
  TITLE     Crystallographic study of coenzyme, coenzyme analogue and substrate
            binding in 6-phosphogluconate dehydrogenase: implications for NADP
            specificity and the enzyme mechanism
  JOURNAL   Structure 2 (7), 651-668 (1994)
   PUBMED   7922042
  REMARK    Erratum:[Structure 1994 Aug 15;2(8):784]
REFERENCE   4  (residues 1 to 483)
  AUTHORS   Somers,D.O., Medd,S.M., Walker,J.E. and Adams,M.J.
  TITLE     Sheep 6-phosphogluconate dehydrogenase. Revised protein sequence
            based upon the sequences of cDNA clones obtained with the
            polymerase chain reaction
  JOURNAL   Biochem. J. 288 (PT 3), 1061-1067 (1992)
   PUBMED   1471978
REFERENCE   5  (residues 1 to 483)
  AUTHORS   Adams,M.J., Gover,S., Leaback,R., Phillips,C. and Somers,D.O.
  TITLE     The structure of 6-phosphogluconate dehydrogenase refined at 2.5 A
            resolution
  JOURNAL   Acta Crystallogr., B 47 (PT 5), 817-820 (1991)
   PUBMED   1793548
REFERENCE   6  (residues 1 to 483)
  AUTHORS   Carne,A. and Walker,J.E.
  TITLE     Amino acid sequence of ovine 6-phosphogluconate dehydrogenase
  JOURNAL   J. Biol. Chem. 258 (21), 12895-12906 (1983)
   PUBMED   6685125
REFERENCE   7  (residues 1 to 483)
  AUTHORS   Adams,M.J., Archibald,I.G., Bugg,C.E., Carne,A., Gover,S.,
            Helliwell,J.R., Pickersgill,R.W. and White,S.W.
  TITLE     The three dimensional structure of sheep liver 6-phosphogluconate
            dehydrogenase at 2.6 A resolution
  JOURNAL   EMBO J. 2 (6), 1009-1014 (1983)
   PUBMED   6641716
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X60195.1.
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Ovis aries"
                     /db_xref="taxon:9940"
     Protein         1..483
                     /product="phosphogluconate dehydrogenase"
                     /EC_number="1.1.1.44"
                     /note="6-phosphogluconate dehydrogenase (decarboxylating)"
                     /calculated_mol_wt=52839
     CDS             1..483
                     /gene="PGD"
                     /gene_synonym="6-PGDH"
                     /coded_by="NM_001009467.2:71..1522"
                     /db_xref="GeneID:443541"
ORIGIN      
        1 maqadialig lavmgqnlil nmndhgfvvc afnrtvskvd dflaneakgt kvlgahslee
       61 mvsklkkprr iillvkagqa vdnfieklvp lldigdiiid ggnseyrdtm rrcrdlkdkg
      121 ilfvgsgvsg gedgarygps lmpggnkeaw phikaifqgi aakvgtgepc cdwvgddgag
      181 hfvkmvhngi eygdmqlice ayhlmkdvlg lghkemakaf eewnktelds flieitasil
      241 kfqdadgkhl lpkirdsagq kgtgkwtais aleygvpvtl igeavfarcl sslkderiqa
      301 skklkgpqni pfegdkksfl edirkalyas kiisyaqgfm llrqaatefg wtlnyggial
      361 mwrggciirs vflgkikdaf drnpglqnll lddffksave ncqdswrrai stgvqagipm
      421 pcfttalsfy dgyrhamlpa nliqaqrdyf gahtyellak pgqfihtnwt ghggsvssss
      481 yna
//