LOCUS       NP_001009299             400 aa            linear   MAM 22-OCT-2008
DEFINITION  renin [Ovis aries].
ACCESSION   NP_001009299
VERSION     NP_001009299.1  GI:57164325
DBSOURCE    REFSEQ: accession NM_001009299.1
KEYWORDS    .
SOURCE      Ovis aries (sheep)
  ORGANISM  Ovis aries
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
            Pecora; Bovidae; Caprinae; Ovis.
REFERENCE   1  (residues 1 to 400)
  AUTHORS   Chen,K., Carey,L.C., Valego,N.K. and Rose,J.C.
  TITLE     Thyroid hormone replacement normalizes renal renin and angiotensin
            receptor expression in thyroidectomized fetal sheep
  JOURNAL   Am. J. Physiol. Regul. Integr. Comp. Physiol. 293 (2), R701-R706
            (2007)
   PUBMED   17567715
  REMARK    GeneRIF: replacement of thyroid hormone in hypothyroid sheep
            fetuses can restore renal ANG II receptor and renin expression and
            secretion to normal
REFERENCE   2  (residues 1 to 400)
  AUTHORS   Aldred,G.P., Fu,P., Crawford,R.J. and Fernley,R.T.
  TITLE     The sequence and tissue expression of ovine renin
  JOURNAL   J. Mol. Endocrinol. 8 (1), 3-11 (1992)
   PUBMED   1543532
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L43524.1.
FEATURES             Location/Qualifiers
     source          1..400
                     /organism="Ovis aries"
                     /db_xref="taxon:9940"
     Protein         1..400
                     /product="renin"
                     /EC_number="3.4.23.15"
                     /function="processing angiotensinogen to angiotensin I"
     sig_peptide     1..14
                     /calculated_mol_wt=1560
     mat_peptide     15..400
                     /product="renin"
                     /EC_number="3.4.23.15"
                     /calculated_mol_wt=42475
     CDS             1..400
                     /gene="REN"
                     /coded_by="NM_001009299.1:45..1247"
                     /db_xref="GeneID:443310"
ORIGIN      
        1 mplwglllal wgcstfslpa dtaafrrifl kkmpsvresl kergvdmaql gaewsqltkt
       61 lsfgnrtspv vltnyldtqy ygeigigtpp qtfkvifdtg sanlwvpstk csplytacei
      121 hslydsless syvengteft iyygsgkvkg flsqdlvtvg gitvtqtfge vtelplrpfm
      181 lakfdgvlgm gfpaqavggv tpvfdhilaq rvltedvfsv yysrdsknsh llggeivlgg
      241 sdpqyyqenf hyvsiskpgs wqirmkgvsv rsttllceeg cmvvvdtgas yisgptsslr
      301 llmealgake lsideyvvnc nqmptlpdis fhlggkaytl tsadyvlqdp ynnisctlal
      361 hgmdippptg pvwvlgatfi rkfytefdrr nnrigfalar
//