LOCUS       NP_001008711             204 aa            linear   PRI 10-FEB-2008
DEFINITION  RNA-binding protein with multiple splicing isoform B [Homo
            sapiens].
ACCESSION   NP_001008711
VERSION     NP_001008711.1  GI:57164971
DBSOURCE    REFSEQ: accession NM_001008711.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 204)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   2  (residues 1 to 204)
  AUTHORS   Hillman,R.T., Green,R.E. and Brenner,S.E.
  TITLE     An unappreciated role for RNA surveillance
  JOURNAL   Genome Biol. 5 (2), R8 (2004)
   PUBMED   14759258
REFERENCE   3  (residues 1 to 204)
  AUTHORS   Shimamoto,A., Kitao,S., Ichikawa,K., Suzuki,N., Yamabe,Y.,
            Imamura,O., Tokutake,Y., Satoh,M., Matsumoto,T., Kuromitsu,J.,
            Kataoka,H., Sugawara,K., Sugawara,M., Sugimoto,M., Goto,M. and
            Furuichi,Y.
  TITLE     A unique human gene that spans over 230 kb in the human chromosome
            8p11-12 and codes multiple family proteins sharing RNA-binding
            motifs
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 93 (20), 10913-10917 (1996)
   PUBMED   8855282
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG480355.1, BE733116.1,
            CR604775.1, D84108.1, AK098281.1, CD518168.1, CN360712.1 and
            AK024192.1.
            
            Summary: This gene encodes a member of the RRM family of
            RNA-binding proteins. The RRM domain is between 80-100 amino acids
            in length and family members contain one to four copies of the
            domain. The RRM domain consists of two short stretches of conserved
            sequence called RNP1 and RNP2, as well as a few highly conserved
            hydrophobic residues. The protein encoded by this gene has a
            single, putative RRM domain in its N-terminus. Alternative splicing
            results in multiple transcript variants encoding different
            isoforms.
            
            Transcript Variant: This variant (2) includes an alternate exon in
            the 3' coding region which results in a frameshift and an early
            stop codon, compared to variant 1. The encoded isoform (B) has a
            distinct C-terminus, compared to isoform A.
FEATURES             Location/Qualifiers
     source          1..204
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p12-p11"
     Protein         1..204
                     /product="RNA-binding protein with multiple splicing
                     isoform B"
                     /calculated_mol_wt=22284
     CDS             1..204
                     /gene="RBPMS"
                     /gene_synonym="HERMES"
                     /coded_by="NM_001008711.1:666..1280"
                     /note="isoform B is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS34875.1"
                     /db_xref="GeneID:11030"
                     /db_xref="HGNC:19097"
                     /db_xref="MIM:601558"
ORIGIN      
        1 mnnggkaeke ntpseanlqe eevrtlfvsg lpldikprel yllfrpfkgy egslikltsk
       61 qpvgfvsfds rseaeaakna lngirfdpei pqtlrlefak antkmaknkl vgtpnpstpl
      121 pntvpqfiar epyeltvpal ypsspevwap yplypaelap alpppaftyp aslhaqlceg
      181 qtvrrshpls apspdsasla wfpv
//