LOCUS NP_001007229 374 aa linear PRI 28-SEP-2008
DEFINITION speckle-type POZ protein [Homo sapiens].
ACCESSION NP_001007229
VERSION NP_001007229.1 GI:56117830
DBSOURCE REFSEQ: accession NM_001007228.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 374)
AUTHORS Bunce,M.W., Boronenkov,I.V. and Anderson,R.A.
TITLE Coordinated activation of the nuclear ubiquitin ligase Cul3-SPOP by
the generation of phosphatidylinositol 5-phosphate
JOURNAL J. Biol. Chem. 283 (13), 8678-8686 (2008)
PUBMED 18218622
REMARK GeneRIF: define a novel mechanism whereby the phosphoinositide
phosphatidylinositol 5-phosphate leads to stimulation of Cul3-SPOP
ubiquitin ligase activity
REFERENCE 2 (residues 1 to 374)
AUTHORS Ewing,R.M., Chu,P., Elisma,F., Li,H., Taylor,P., Climie,S.,
McBroom-Cerajewski,L., Robinson,M.D., O'Connor,L., Li,M.,
Taylor,R., Dharsee,M., Ho,Y., Heilbut,A., Moore,L., Zhang,S.,
Ornatsky,O., Bukhman,Y.V., Ethier,M., Sheng,Y., Vasilescu,J.,
Abu-Farha,M., Lambert,J.P., Duewel,H.S., Stewart,I.I., Kuehl,B.,
Hogue,K., Colwill,K., Gladwish,K., Muskat,B., Kinach,R.,
Adams,S.L., Moran,M.F., Morin,G.B., Topaloglou,T. and Figeys,D.
TITLE Large-scale mapping of human protein-protein interactions by mass
spectrometry
JOURNAL Mol. Syst. Biol. 3, 89 (2007)
PUBMED 17353931
REFERENCE 3 (residues 1 to 374)
AUTHORS Zhang,Q., Zhang,L., Wang,B., Ou,C.Y., Chien,C.T. and Jiang,J.
TITLE A hedgehog-induced BTB protein modulates hedgehog signaling by
degrading Ci/Gli transcription factor
JOURNAL Dev. Cell 10 (6), 719-729 (2006)
PUBMED 16740475
REFERENCE 4 (residues 1 to 374)
AUTHORS Kwon,J.E., La,M., Oh,K.H., Oh,Y.M., Kim,G.R., Seol,J.H., Baek,S.H.,
Chiba,T., Tanaka,K., Bang,O.S., Joe,C.O. and Chung,C.H.
TITLE BTB domain-containing speckle-type POZ protein (SPOP) serves as an
adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase
JOURNAL J. Biol. Chem. 281 (18), 12664-12672 (2006)
PUBMED 16524876
REMARK GeneRIF: SPOP/Cul3-ubiquitin ligase plays an essential role in the
control of Daxx level and, thus, in the regulation of Daxx-mediated
cellular processes, including transcriptional regulation and
apoptosis
REFERENCE 5 (residues 1 to 374)
AUTHORS Kent,D., Bush,E.W. and Hooper,J.E.
TITLE Roadkill attenuates Hedgehog responses through degradation of
Cubitus interruptus
JOURNAL Development 133 (10), 2001-2010 (2006)
PUBMED 16651542
REFERENCE 6 (residues 1 to 374)
AUTHORS Diefenbach,A., Tomasello,E., Lucas,M., Jamieson,A.M., Hsia,J.K.,
Vivier,E. and Raulet,D.H.
TITLE Selective associations with signaling proteins determine
stimulatory versus costimulatory activity of NKG2D
JOURNAL Nat. Immunol. 3 (12), 1142-1149 (2002)
PUBMED 12426565
REMARK Erratum:[Nat Immunol. 2004 Jun;5(6):658]
REFERENCE 7 (residues 1 to 374)
AUTHORS Gilfillan,S., Ho,E.L., Cella,M., Yokoyama,W.M. and Colonna,M.
TITLE NKG2D recruits two distinct adapters to trigger NK cell activation
and costimulation
JOURNAL Nat. Immunol. 3 (12), 1150-1155 (2002)
PUBMED 12426564
REFERENCE 8 (residues 1 to 374)
AUTHORS Zapata,J.M., Pawlowski,K., Haas,E., Ware,C.F., Godzik,A. and
Reed,J.C.
TITLE A diverse family of proteins containing tumor necrosis factor
receptor-associated factor domains
JOURNAL J. Biol. Chem. 276 (26), 24242-24252 (2001)
PUBMED 11279055
REFERENCE 9 (residues 1 to 374)
AUTHORS Wu,J., Song,Y., Bakker,A.B., Bauer,S., Spies,T., Lanier,L.L. and
Phillips,J.H.
TITLE An activating immunoreceptor complex formed by NKG2D and DAP10
JOURNAL Science 285 (5428), 730-732 (1999)
PUBMED 10426994
REFERENCE 10 (residues 1 to 374)
AUTHORS Nagai,Y., Kojima,T., Muro,Y., Hachiya,T., Nishizawa,Y.,
Wakabayashi,T. and Hagiwara,M.
TITLE Identification of a novel nuclear speckle-type protein, SPOP
JOURNAL FEBS Lett. 418 (1-2), 23-26 (1997)
PUBMED 9414087
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BX282325.1, BC001269.1,
AK123385.1, W84567.1, BM693397.1, BQ226031.1 and AW449169.1.
Summary: This gene encodes a protein that may modulate the
transcriptional repression activities of death-associated protein 6
(DAXX), which interacts with histone deacetylase, core histones,
and other histone-associated proteins. In mouse, the encoded
protein binds to the putative leucine zipper domain of macroH2A1.2,
a variant H2A histone that is enriched on inactivated X
chromosomes. The BTB/POZ domain of this protein has been shown in
other proteins to mediate transcriptional repression and to
interact with components of histone deacetylase co-repressor
complexes. Alternative splicing of this gene results in multiple
transcript variants encoding the same protein. [provided by
RefSeq].
Transcript Variant: This variant (4) differs in the 5' UTR compared
to variant 1. Transcript variants 1-6 encode the same protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..374
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q21.33"
Protein 1..374
/product="speckle-type POZ protein"
/calculated_mol_wt=42001
CDS 1..374
/gene="SPOP"
/gene_synonym="TEF2"
/coded_by="NM_001007228.1:298..1422"
/db_xref="CCDS:CCDS11551.1"
/db_xref="GeneID:8405"
/db_xref="HGNC:11254"
/db_xref="HPRD:16004"
/db_xref="MIM:602650"
ORIGIN
1 msrvpspppp aemssgpvae swcytqikvv kfsymwtinn fsfcreemge viksstfssg
61 andklkwclr vnpkgldees kdylslylll vscpksevra kfkfsilnak geetkamesq
121 rayrfvqgkd wgfkkfirrd flldeangll pddkltlfce vsvvqdsvni sgqntmnmvk
181 vpecrladel gglwensrft dcclcvagqe fqahkailaa rspvfsamfe hemeeskknr
241 veindvepev fkemmcfiyt gkapnldkma ddllaaadky alerlkvmce dalcsnlsve
301 naaeililad lhsadqlktq avdfinyhas dvletsgwks mvvshphlva eayrslasaq
361 cpflgpprkr lkqs
//