LOCUS NP_001005783 351 aa linear PRI 22-OCT-2008
DEFINITION hydroxyacid oxidase 2 [Homo sapiens].
ACCESSION NP_001005783
VERSION NP_001005783.1 GI:54234014
DBSOURCE REFSEQ: accession NM_001005783.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 351)
AUTHORS Gregory,S.G., Barlow,K.F., McLay,K.E., Kaul,R., Swarbreck,D.,
Dunham,A., Scott,C.E., Howe,K.L., Woodfine,K., Spencer,C.C.,
Jones,M.C., Gillson,C., Searle,S., Zhou,Y., Kokocinski,F.,
McDonald,L., Evans,R., Phillips,K., Atkinson,A., Cooper,R.,
Jones,C., Hall,R.E., Andrews,T.D., Lloyd,C., Ainscough,R.,
Almeida,J.P., Ambrose,K.D., Anderson,F., Andrew,R.W., Ashwell,R.I.,
Aubin,K., Babbage,A.K., Bagguley,C.L., Bailey,J., Beasley,H.,
Bethel,G., Bird,C.P., Bray-Allen,S., Brown,J.Y., Brown,A.J.,
Buckley,D., Burton,J., Bye,J., Carder,C., Chapman,J.C., Clark,S.Y.,
Clarke,G., Clee,C., Cobley,V., Collier,R.E., Corby,N.,
Coville,G.J., Davies,J., Deadman,R., Dunn,M., Earthrowl,M.,
Ellington,A.G., Errington,H., Frankish,A., Frankland,J., French,L.,
Garner,P., Garnett,J., Gay,L., Ghori,M.R., Gibson,R., Gilby,L.M.,
Gillett,W., Glithero,R.J., Grafham,D.V., Griffiths,C.,
Griffiths-Jones,S., Grocock,R., Hammond,S., Harrison,E.S., Hart,E.,
Haugen,E., Heath,P.D., Holmes,S., Holt,K., Howden,P.J., Hunt,A.R.,
Hunt,S.E., Hunter,G., Isherwood,J., James,R., Johnson,C.,
Johnson,D., Joy,A., Kay,M., Kershaw,J.K., Kibukawa,M.,
Kimberley,A.M., King,A., Knights,A.J., Lad,H., Laird,G., Lawlor,S.,
Leongamornlert,D.A., Lloyd,D.M., Loveland,J., Lovell,J., Lush,M.J.,
Lyne,R., Martin,S., Mashreghi-Mohammadi,M., Matthews,L.,
Matthews,N.S., McLaren,S., Milne,S., Mistry,S., Moore,M.J.,
Nickerson,T., O'Dell,C.N., Oliver,K., Palmeiri,A., Palmer,S.A.,
Parker,A., Patel,D., Pearce,A.V., Peck,A.I., Pelan,S., Phelps,K.,
Phillimore,B.J., Plumb,R., Rajan,J., Raymond,C., Rouse,G.,
Saenphimmachak,C., Sehra,H.K., Sheridan,E., Shownkeen,R., Sims,S.,
Skuce,C.D., Smith,M., Steward,C., Subramanian,S., Sycamore,N.,
Tracey,A., Tromans,A., Van Helmond,Z., Wall,M., Wallis,J.M.,
White,S., Whitehead,S.L., Wilkinson,J.E., Willey,D.L., Williams,H.,
Wilming,L., Wray,P.W., Wu,Z., Coulson,A., Vaudin,M., Sulston,J.E.,
Durbin,R., Hubbard,T., Wooster,R., Dunham,I., Carter,N.P.,
McVean,G., Ross,M.T., Harrow,J., Olson,M.V., Beck,S., Rogers,J.,
Bentley,D.R., Banerjee,R., Bryant,S.P., Burford,D.C., Burrill,W.D.,
Clegg,S.M., Dhami,P., Dovey,O., Faulkner,L.M., Gribble,S.M.,
Langford,C.F., Pandian,R.D., Porter,K.M. and Prigmore,E.
TITLE The DNA sequence and biological annotation of human chromosome 1
JOURNAL Nature 441 (7091), 315-321 (2006)
PUBMED 16710414
REMARK Erratum:[Nature. 2006 Oct 26;443(7114):1013. Banerjee, R [added];
Bryant, SP [added]; Burford, DC [added]; Burrill, WDH [added];
Clegg, SM [added]; Dhami, P [added]; Dovey, O [added]; Faulkner, LM
[added]; Gribble, SM [added]; Langford, CF [added]; Pandian, RD
[added]; Porter, KM [added]; Prigmore, E [added]]
REFERENCE 2 (residues 1 to 351)
AUTHORS Jones,J.M., Morrell,J.C. and Gould,S.J.
TITLE Identification and characterization of HAOX1, HAOX2, and HAOX3,
three human peroxisomal 2-hydroxy acid oxidases
JOURNAL J. Biol. Chem. 275 (17), 12590-12597 (2000)
PUBMED 10777549
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from CB121424.1, BG428999.1,
BC020863.1 and AF231917.1.
Summary: This gene is one of three related genes that have
2-hydroxyacid oxidase activity yet differ in encoded protein amino
acid sequence, tissue expression and substrate preference.
Subcellular location of the encoded protein is the peroxisome.
Specifically, this gene is expressed predominantly in liver and
kidney and has the highest activity toward the substrate
2-hydroxypalmitate. Two alternatively spliced variants encoding the
same isoform have been described. [provided by RefSeq].
Transcript Variant: This variant (2) differs in the 5' UTR compared
to variant 1. Both variants 1 and 2 encode the same protein.
FEATURES Location/Qualifiers
source 1..351
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p13.3-p13.1"
Protein 1..351
/product="hydroxyacid oxidase 2"
/EC_number="1.1.3.15"
/note="(S)-2-hydroxy-acid oxidase; glycolate oxidase;
long-chain L-2-hydroxy acid oxidase; growth-inhibiting
protein 16"
/calculated_mol_wt=38708
CDS 1..351
/gene="HAO2"
/gene_synonym="GIG16"
/gene_synonym="HAOX2"
/coded_by="NM_001005783.1:353..1408"
/db_xref="CCDS:CCDS901.1"
/db_xref="GeneID:51179"
/db_xref="HGNC:4810"
/db_xref="MIM:605176"
ORIGIN
1 mslvcltdfq ahareqlsks trdfieggad dsitrddnia afkrirlrpr ylrdvsevdt
61 rttiqgeeis apiciaptgf hclvwpdgem staraaqaag icyitstfas cslediviaa
121 peglrwfqly vhpdlqlnkq liqrveslgf kalvitldtp vcgnrrhdir nqlrrnltlt
181 dlqspkkgna ipyfqmtpis tslcwndlsw fqsitrlpii lkgiltkeda elavkhnvqg
241 iivsnhggrq ldevlasida ltevvaavkg kievyldggv rtgndvlkal algakciflg
301 rpilwglack gehgvkevln iltnefhtsm altgcrsvae inrnlvqfsr l
//