LOCUS NP_001004356 504 aa linear PRI 05-AUG-2008
DEFINITION fibroblast growth factor receptor-like 1 precursor [Homo sapiens].
ACCESSION NP_001004356
VERSION NP_001004356.1 GI:51988912
DBSOURCE REFSEQ: accession NM_001004356.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 504)
AUTHORS Rieckmann,T., Kotevic,I. and Trueb,B.
TITLE The cell surface receptor FGFRL1 forms constitutive dimers that
promote cell adhesion
JOURNAL Exp. Cell Res. 314 (5), 1071-1081 (2008)
PUBMED 18061161
REMARK GeneRIF: The extracellular domain of recombinant FGFRL1 promoted
cell adhesion, but not cell spreading. Adhesion was mediated by
heparan sulfate glycosaminoglycans located at the cell surface.
REFERENCE 2 (residues 1 to 504)
AUTHORS Schild,C. and Trueb,B.
TITLE Aberrant expression of FGFRL1, a novel FGF receptor, in ovarian
tumors
JOURNAL Int. J. Mol. Med. 16 (6), 1169-1173 (2005)
PUBMED 16273302
REMARK GeneRIF: Screening of 241 different human tumors with the help of a
cancer profiling array suggested major alterations in the relative
expression of FGFRL1 in ovarian tumors
REFERENCE 3 (residues 1 to 504)
AUTHORS Antoine,M., Wirz,W., Tag,C.G., Mavituna,M., Emans,N., Korff,T.,
Stoldt,V., Gressner,A.M. and Kiefer,P.
TITLE Expression pattern of fibroblast growth factors (FGFs), their
receptors and antagonists in primary endothelial cells and vascular
smooth muscle cells
JOURNAL Growth Factors 23 (2), 87-95 (2005)
PUBMED 16019430
REMARK GeneRIF: analysis of FGF18 and FGFR5(FGFRL1) expression in primary
endothelial cells and vascular smooth muscle cells
REFERENCE 4 (residues 1 to 504)
AUTHORS Zhang,Z. and Henzel,W.J.
TITLE Signal peptide prediction based on analysis of experimentally
verified cleavage sites
JOURNAL Protein Sci. 13 (10), 2819-2824 (2004)
PUBMED 15340161
REFERENCE 5 (residues 1 to 504)
AUTHORS Trueb,B., Zhuang,L., Taeschler,S. and Wiedemann,M.
TITLE Characterization of FGFRL1, a novel fibroblast growth factor (FGF)
receptor preferentially expressed in skeletal tissues
JOURNAL J. Biol. Chem. 278 (36), 33857-33865 (2003)
PUBMED 12813049
REFERENCE 6 (residues 1 to 504)
AUTHORS Sleeman,M., Fraser,J., McDonald,M., Yuan,S., White,D.,
Grandison,P., Kumble,K., Watson,J.D. and Murison,J.G.
TITLE Identification of a new fibroblast growth factor receptor, FGFR5
JOURNAL Gene 271 (2), 171-182 (2001)
PUBMED 11418238
REFERENCE 7 (residues 1 to 504)
AUTHORS Kim,I., Moon,S., Yu,K., Kim,U. and Koh,G.Y.
TITLE A novel fibroblast growth factor receptor-5 preferentially
expressed in the pancreas(1)
JOURNAL Biochim. Biophys. Acta 1518 (1-2), 152-156 (2001)
PUBMED 11267671
REFERENCE 8 (residues 1 to 504)
AUTHORS Wiedemann,M. and Trueb,B.
TITLE Characterization of a novel protein (FGFRL1) from human cartilage
related to FGF receptors
JOURNAL Genomics 69 (2), 275-279 (2000)
PUBMED 11031111
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AY358303.1, BQ689625.1 and
BC015228.1.
Summary: The protein encoded by this gene is a member of the
fibroblast growth factor receptor (FGFR) family, where amino acid
sequence is highly conserved between members and throughout
evolution. FGFR family members differ from one another in their
ligand affinities and tissue distribution. A full-length
representative protein would consist of an extracellular region,
composed of three immunoglobulin-like domains, a single hydrophobic
membrane-spanning segment and a cytoplasmic tyrosine kinase domain.
The extracellular portion of the protein interacts with fibroblast
growth factors, setting in motion a cascade of downstream signals,
ultimately influencing mitogenesis and differentiation. A marked
difference between this gene product and the other family members
is its lack of a cytoplasmic tyrosine kinase domain. The result is
a transmembrane receptor that could interact with other family
members and potentially inhibit signaling. Multiple alternatively
spliced transcript variants encoding the same isoform have been
found for this gene. [provided by RefSeq].
Transcript Variant: This variant (1) represents the longest
transcript.
FEATURES Location/Qualifiers
source 1..504
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="4"
/map="4p16"
Protein 1..504
/product="fibroblast growth factor receptor-like 1
precursor"
/EC_number="3.2.1.76"
/note="fibroblast growth factor receptor 5; FGF homologous
factor receptor"
sig_peptide 1..24
/calculated_mol_wt=2427
mat_peptide 25..504
/product="fibroblast growth factor receptor-like 1"
/calculated_mol_wt=52128
CDS 1..504
/gene="FGFRL1"
/gene_synonym="FHFR"
/gene_synonym="FGFR5"
/coded_by="NM_001004356.2:150..1664"
/db_xref="CCDS:CCDS3344.1"
/db_xref="GeneID:53834"
/db_xref="HGNC:3693"
/db_xref="HPRD:16163"
/db_xref="MIM:605830"
ORIGIN
1 mtpsplllll lpplllgafp paaaargppk madkvvprqv arlgrtvrlq cpvegdpppl
61 tmwtkdgrti hsgwsrfrvl pqglkvkqve redagvyvck atngfgslsv nytlvvlddi
121 spgkeslgpd sssggqedpa sqqwarprft qpskmrrrvi arpvgssvrl kcvasghprp
181 ditwmkddqa ltrpeaaepr kkkwtlslkn lrpedsgkyt crvsnragai natykvdviq
241 rtrskpvltg thpvnttvdf ggttsfqckv rsdvkpviqw lkrveygaeg rhnstidvgg
301 qkfvvlptgd vwsrpdgsyl nkllitrarq ddagmyiclg antmgysfrs afltvlpdpk
361 ppgppvasss satslpwpvv igipagavfi lgtlllwlcq aqkkpctpap applpghrpp
421 gtardrsgdk dlpslaalsa gpgvglceeh gspaapqhll gpgpvagpkl ypklytdiht
481 hththshths hvegkvhqhi hyqc
//