LOCUS       NP_001004037             146 aa            linear   MAM 22-OCT-2008
DEFINITION  phospholipase A2, group IB [Sus scrofa].
ACCESSION   NP_001004037
VERSION     NP_001004037.1  GI:51592123
DBSOURCE    REFSEQ: accession NM_001004037.1
KEYWORDS    .
SOURCE      Sus scrofa (pig)
  ORGANISM  Sus scrofa
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
            Sus.
REFERENCE   1  (residues 1 to 146)
  AUTHORS   Bai,S., Jain,M.K. and Berg,O.G.
  TITLE     Contiguous binding of decylsulfate on the interface-binding surface
            of pancreatic phospholipase A2
  JOURNAL   Biochemistry 47 (9), 2899-2907 (2008)
   PUBMED   18260608
  REMARK    GeneRIF: Results show that the decylsulfate epitope for the
            successive E i (#) complexes increasingly resembles the micellar
            complex formed by the binding of PLA2 to preformed micelles.
REFERENCE   2  (residues 1 to 146)
  AUTHORS   Gorovetz,M., Schwob,O., Krimsky,M., Yedgar,S. and Reich,R.
  TITLE     MMP production in human fibrosarcoma cells and their invasiveness
            are regulated by group IB secretory phospholipase A2
            receptor-mediated activation of cytosolic phospholipase A2
  JOURNAL   Front. Biosci. 13, 1917-1925 (2008)
   PUBMED   17981679
  REMARK    GeneRIF: MMP-2/9 production is regulated by sPLA2-IB acting as a
            receptor ligand to activate cPLA2
            Review article
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 146)
  AUTHORS   Pan,Y.H. and Bahnson,B.J.
  TITLE     Structural basis for bile salt inhibition of pancreatic
            phospholipase A2
  JOURNAL   J. Mol. Biol. 369 (2), 439-450 (2007)
   PUBMED   17434532
  REMARK    GeneRIF: Results describe the structural basis for bile salt
            inhibition of pancreatic phospholipase A2.
REFERENCE   4  (residues 1 to 146)
  AUTHORS   Wacklin,H.P., Tiberg,F., Fragneto,G. and Thomas,R.K.
  TITLE     Distribution of reaction products in phospholipase A2 hydrolysis
  JOURNAL   Biochim. Biophys. Acta 1768 (5), 1036-1049 (2007)
   PUBMED   17355873
  REMARK    GeneRIF: Porcine pancreatic PLA(2) shows a long lag phase of
            several hours during which the enzyme binds to the bilayer surface,
            but only 5+/-3% of the lipids react before the onset of rapid
            hydrolysis.
REFERENCE   5  (residues 1 to 146)
  AUTHORS   Jo,E.J., Lee,H.Y., Lee,Y.N., Kim,J.I., Kang,H.K., Park,D.W.,
            Baek,S.H., Kwak,J.Y. and Bae,Y.S.
  TITLE     Group IB secretory phospholipase A2 stimulates CXC chemokine ligand
            8 production via ERK and NF-kappa B in human neutrophils
  JOURNAL   J. Immunol. 173 (10), 6433-6439 (2004)
   PUBMED   15528384
  REMARK    GeneRIF: Porcine group IB secretory phospholipase A2 (PLA2G1B)
            stimulates the expression and secretion of CXC chemokine ligand 8
            (CXCL8) in human neutrophils without affecting other
            proinflammatory cytokines.
REFERENCE   6  (residues 1 to 146)
  AUTHORS   Dekker,N., Peters,A.R., Slotboom,A.J., Boelens,R., Kaptein,R. and
            de Haas,G.
  TITLE     Porcine pancreatic phospholipase A2: sequence-specific 1H and 15N
            NMR assignments and secondary structure
  JOURNAL   Biochemistry 30 (12), 3135-3146 (1991)
   PUBMED   2007145
REFERENCE   7  (residues 1 to 146)
  AUTHORS   Thunnissen,M.M., Kalk,K.H., Drenth,J. and Dijkstra,B.W.
  TITLE     Structure of an engineered porcine phospholipase A2 with enhanced
            activity at 2.1 A resolution. Comparison with the wild-type porcine
            and Crotalus atrox phospholipase A2
  JOURNAL   J. Mol. Biol. 216 (2), 425-439 (1990)
   PUBMED   2254938
REFERENCE   8  (residues 1 to 146)
  AUTHORS   Thunnissen,M.M., Ab,E., Kalk,K.H., Drenth,J., Dijkstra,B.W.,
            Kuipers,O.P., Dijkman,R., de Haas,G.H. and Verheij,H.M.
  TITLE     X-ray structure of phospholipase A2 complexed with a
            substrate-derived inhibitor
  JOURNAL   Nature 347 (6294), 689-691 (1990)
   PUBMED   2215698
REFERENCE   9  (residues 1 to 146)
  AUTHORS   Tomasselli,A.G., Hui,J., Fisher,J., Zurcher-Neely,H., Reardon,I.M.,
            Oriaku,E., Kezdy,F.J. and Heinrikson,R.L.
  TITLE     Dimerization and activation of porcine pancreatic phospholipase A2
            via substrate level acylation of lysine 56
  JOURNAL   J. Biol. Chem. 264 (17), 10041-10047 (1989)
   PUBMED   2498336
REFERENCE   10 (residues 1 to 146)
  AUTHORS   Puijk,W.C., Verheij,H.M. and De Haas,G.H.
  TITLE     The primary structure of phospholipase A2 from porcine pancreas. A
            reinvestigation
  JOURNAL   Biochim. Biophys. Acta 492 (2), 254-259 (1977)
   PUBMED   884127
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M21055.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the
            Entrez Gene record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..146
                     /organism="Sus scrofa"
                     /db_xref="taxon:9823"
     Protein         1..146
                     /product="phospholipase A2, group IB"
                     /EC_number="3.1.1.4"
                     /note="group IB secretory phospholipase A(2)"
                     /calculated_mol_wt=16148
     CDS             1..146
                     /gene="PLA2G1B"
                     /gene_synonym="PLA2"
                     /gene_synonym="sPLA(2)-IB"
                     /coded_by="NM_001004037.1:38..478"
                     /db_xref="GeneID:445525"
ORIGIN      
        1 mkflvlavll tvgaaqegis sralwqfrsm ikcaipgshp lmdfnnygcy cglggsgtpv
       61 deldrcceth dncyrdaknl dsckflvdnp ytesysyscs nteitcnskn naceaficnc
      121 drnaaicfsk apynkehknl dtkkyc
//