LOCUS       NP_001003158            1205 aa            linear   MAM 22-OCT-2008
DEFINITION  nitric oxide synthase 3 (endothelial cell) [Canis lupus
            familiaris].
ACCESSION   NP_001003158
VERSION     NP_001003158.1  GI:50978892
DBSOURCE    REFSEQ: accession NM_001003158.1
KEYWORDS    .
SOURCE      Canis lupus familiaris (dog)
  ORGANISM  Canis lupus familiaris
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
            Canis.
REFERENCE   1  (residues 1 to 1205)
  AUTHORS   Williams,J.G., Rincon-Skinner,T., Sun,D., Wang,Z., Zhang,S.,
            Zhang,X. and Hintze,T.H.
  TITLE     Role of nitric oxide in the coupling of myocardial oxygen
            consumption and coronary vascular dynamics during pregnancy in the
            dog
  JOURNAL   Am. J. Physiol. Heart Circ. Physiol. 293 (4), H2479-H2486 (2007)
   PUBMED   17644579
  REMARK    GeneRIF: Increases in eNOS and SOD-1 promote the coupling of oxygen
            delivery and efficiency in the heart during pregnancy.
REFERENCE   2  (residues 1 to 1205)
  AUTHORS   Gill,R.M., Braz,J.C., Jin,N., Etgen,G.J. and Shen,W.
  TITLE     Restoration of impaired endothelium-dependent coronary vasodilation
            in failing heart: role of eNOS phosphorylation and CGMP/cGK-I
            signaling
  JOURNAL   Am. J. Physiol. Heart Circ. Physiol. 292 (6), H2782-H2790 (2007)
   PUBMED   17322419
  REMARK    GeneRIF: NOS3 phosphorylation and enhanced cGMP/protein kinase G
            activity contributes to restoration of coronary vascular
            vasodilation during recovery from heart failure.
REFERENCE   3  (residues 1 to 1205)
  AUTHORS   Grassi,B., Hogan,M.C., Kelley,K.M., Howlett,R.A. and Gladden,L.B.
  TITLE     Effects of nitric oxide synthase inhibition by L-NAME on oxygen
            uptake kinetics in isolated canine muscle in situ
  JOURNAL   J. Physiol. (Lond.) 568 (PT 3), 1021-1033 (2005)
   PUBMED   16081490
  REMARK    GeneRIF: The down-regulation of mitochondrial respiration by NO
            does not limit the kinetics of adjustment of oxidative metabolism
            at exercise onset.
REFERENCE   4  (residues 1 to 1205)
  AUTHORS   Cai,W.J., Kocsis,E., Luo,X., Schaper,W. and Schaper,J.
  TITLE     Expression of endothelial nitric oxide synthase in the vascular
            wall during arteriogenesis
  JOURNAL   Mol. Cell. Biochem. 264 (1-2), 193-200 (2004)
   PUBMED   15544048
  REMARK    GeneRIF: the expression pattern of eNOS is closely associated with
            the development of collateral vessels, suggesting that eNOS plays
            an important role in arteriogenesis
REFERENCE   5  (residues 1 to 1205)
  AUTHORS   Schwemmer,M. and Bassenge,E.
  TITLE     Assembly and characterization of canine heart endothelial nitric
            oxide synthase cDNA and 5'-flanking sequence by homology (RT-)PCR
            cloning
  JOURNAL   Nitric Oxide 3 (3), 254-264 (1999)
   PUBMED   10442857
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF143503.1.
FEATURES             Location/Qualifiers
     source          1..1205
                     /organism="Canis lupus familiaris"
                     /sub_species="familiaris"
                     /db_xref="taxon:9615"
                     /chromosome="16"
                     /map="16"
     Protein         1..1205
                     /product="nitric oxide synthase 3 (endothelial cell)"
                     /EC_number="1.14.13.39"
                     /calculated_mol_wt=132916
     CDS             1..1205
                     /gene="NOS3"
                     /gene_synonym="NOS"
                     /coded_by="NM_001003158.1:1268..4885"
                     /db_xref="GeneID:403784"
ORIGIN      
        1 mgnlksvgqe pgppcglglg lglglcgkqg pasptsepsr apalapppsp ppapdhsspp
       61 ltrppdgpkf prvknwevgs itydtlsaqs qqdgpctprr clgslvfprk lqsrpsqnpa
      121 ppeqllsqar dfisqyyssi krsgsqaheq rlqeveaeva atgtyqlres elvfgakqaw
      181 rnaprcvgri qwgklqvfda rdcssaqemf tyicnhikya tnrgnlrsai tvfpqrasgr
      241 gdfriwnsql vryagyrqqd gsvrgdpanv eitelciqhg wtpgngrfdv lplllqapde
      301 ppelfalppe lvlevplehp tlewfaalgl rwyalpavsn mlleigglef paapfsgwym
      361 steigtrnlc dphryniled vavcmdldtr ttsslwkdka aveinlavlh syqlakvtiv
      421 dhhaatasfm khleneqkar ggcpadwawi vppisgsltp vfhqemvnyv lspafryqtd
      481 pwkgsaskga gvtrkktfke vanavkisas lmgtvmakrv katilygset graqsyaqql
      541 grlfrkafdp rvlcmdeydv vslehetlvl vvtstfgngd ppengesfaa almemsgsyn
      601 ssprpeqhks ykirfnsvsc sdplvsswrr krkesrntds agalgtlrfc vfglgsrayp
      661 hfcafaravd trleelgger llqlgqgdel cgqeeafggw aqaafqaswe tfcvgedaka
      721 aardifspkr twkrqryrls aqaeglqllp glihvhrrkm vqatvlaven lqsskstrat
      781 ilvrldtgsq ealqyqpgdh igicppnrpg lveallsrve dppppgepva veqlekgspg
      841 gpppswvrdp rlppctlrqa ltfflditsp pspqllrlls tlaeesseqq eleslsqdpr
      901 ryeewkwfrc ptllevleqf psvalpapll ltqlpllqpr yysvssapsa hpgeihltva
      961 vlayrtqdgl gplhygvcst wlsqlkagdp vpcfirgaps frlppdpslp cilvgpgtgi
     1021 apfrgfwqgr lhdiyskglq papmtlvfgc rcsqldhlyr devqdaqqrg vfgrvltafs
     1081 repdspktyv qdilrtelaa evhrvlcler ghmfvcgdvt matsvlqtvq rilategdme
     1141 ldeagdvigv lrdqqryhed ifgltlrtqe vtsrirtqsf slqerhlrga vpwaldppgp
     1201 dtvgp
//