LOCUS       NP_001002001             348 aa            linear   PRI 22-OCT-2008
DEFINITION  guanosine monophosphate reductase 2 isoform 2 [Homo sapiens].
ACCESSION   NP_001002001
VERSION     NP_001002001.1  GI:50541954
DBSOURCE    REFSEQ: accession NM_001002001.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 348)
  AUTHORS   Zhang,J., Zhang,W., Zou,D., Chen,G., Wan,T., Zhang,M. and Cao,X.
  TITLE     Cloning and functional characterization of GMPR2, a novel human
            guanosine monophosphate reductase, which promotes the monocytic
            differentiation of HL-60 leukemia cells
  JOURNAL   J. Cancer Res. Clin. Oncol. 129 (2), 76-83 (2003)
   PUBMED   12669231
  REMARK    GeneRIF: GMPR2 is a novel human GMP reductase, and overexpression
            of GMPR2 can promote the monocytic differentiation of HL-60
            leukemia cells.
REFERENCE   2  (residues 1 to 348)
  AUTHORS   Deng,Y., Wang,Z., Ying,K., Gu,S., Ji,C., Huang,Y., Gu,X., Wang,Y.,
            Xu,Y., Li,Y., Xie,Y. and Mao,Y.
  TITLE     NADPH-dependent GMP reductase isoenzyme of human (GMPR2).
            Expression, purification, and kinetic properties
  JOURNAL   Int. J. Biochem. Cell Biol. 34 (9), 1035-1050 (2002)
   PUBMED   12009299
  REMARK    GeneRIF: Data suggest the existence of two distinct types of human
            GMP reductase molecular species, which can be used to explain the
            bimodal saturation curve noted with purified human erythrocyte GMP
            reductase.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX161436.1, BC009832.2 and CA447126.1.
FEATURES             Location/Qualifiers
     source          1..348
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q12"
     Protein         1..348
                     /product="guanosine monophosphate reductase 2 isoform 2"
                     /EC_number="1.7.1.7"
                     /note="guanosine monophosphate reductase isolog; GMP
                     reductase 2; guanosine 5'-monophosphate oxidoreductase 2"
                     /calculated_mol_wt=37743
     CDS             1..348
                     /gene="GMPR2"
                     /gene_synonym="MGC830"
                     /gene_synonym="MGC15084"
                     /coded_by="NM_001002001.1:383..1429"
                     /note="isoform 2 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS41935.1"
                     /db_xref="GeneID:51292"
                     /db_xref="HGNC:4377"
                     /db_xref="HPRD:13590"
                     /db_xref="MIM:610781"
ORIGIN      
        1 mphidndvkl dfkdvllrpk rstlksrsev dltrsfsfrn skqtysgvpi iaanmdtvgt
       61 femakvlckf slftavhkhy slvqwqefag qnpdclehla assgtgssdf eqleqileai
      121 pqvkyicldv angysehfve fvkdvrkrfp qhtimagnvv tgemveelil sgadiikvgi
      181 gpgsvcttrk ktgvgypqls avmecadaah glkghiisdg gcscpgdvak afgagadfvm
      241 lggmlaghse sggelierdg kkyklfygms semamkkyag gvaeyraseg ktvevpfkgd
      301 vehtirdilg girstctyvg aaklkelsrr ttfirvtqqv npifseac
//