LOCUS       NP_001001539             316 aa            linear   MAM 22-OCT-2008
DEFINITION  aldose reductase [Sus scrofa].
ACCESSION   NP_001001539
VERSION     NP_001001539.1  GI:48374071
DBSOURCE    REFSEQ: accession NM_001001539.1
KEYWORDS    .
SOURCE      Sus scrofa (pig)
  ORGANISM  Sus scrofa
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
            Sus.
REFERENCE   1  (residues 1 to 316)
  AUTHORS   Sotriffer,C.A., Kramer,O. and Klebe,G.
  TITLE     Probing flexibility and 'induced-fit' phenomena in aldose reductase
            by comparative crystal structure analysis and molecular dynamics
            simulations
  JOURNAL   Proteins 56 (1), 52-66 (2004)
   PUBMED   15162486
  REMARK    GeneRIF: crystal structure analysis and molecular dynamics
            simulations
REFERENCE   2  (residues 1 to 316)
  AUTHORS   Urzhumtsev,A., Tete-Favier,F., Mitschler,A., Barbanton,J.,
            Barth,P., Urzhumtseva,L., Biellmann,J.F., Podjarny,A. and Moras,D.
  TITLE     A 'specificity' pocket inferred from the crystal structures of the
            complexes of aldose reductase with the pharmaceutically important
            inhibitors tolrestat and sorbinil
  JOURNAL   Structure 5 (5), 601-612 (1997)
   PUBMED   9195881
REFERENCE   3  (residues 1 to 316)
  AUTHORS   Jaquinod,M., Potier,N., Klarskov,K., Reymann,J.M., Sorokine,O.,
            Kieffer,S., Barth,P., Andriantomanga,V., Biellmann,J.F. and Van
            Dorsselaer,A.
  TITLE     Sequence of pig lens aldose reductase and electrospray mass
            spectrometry of non-covalent and covalent complexes
  JOURNAL   Eur. J. Biochem. 218 (3), 893-903 (1993)
   PUBMED   8281941
REFERENCE   4  (residues 1 to 316)
  AUTHORS   Kubiseski,T.J., Green,N.C. and Flynn,T.G.
  TITLE     Location of an essential arginine residue in the primary structure
            of pig aldose reductase
  JOURNAL   Adv. Exp. Med. Biol. 328, 259-265 (1993)
   PUBMED   8493902
REFERENCE   5  (residues 1 to 316)
  AUTHORS   Wilson,D.K., Bohren,K.M., Gabbay,K.H. and Quiocho,F.A.
  TITLE     An unlikely sugar substrate site in the 1.65 A structure of the
            human aldose reductase holoenzyme implicated in diabetic
            complications
  JOURNAL   Science 257 (5066), 81-84 (1992)
   PUBMED   1621098
REFERENCE   6  (residues 1 to 316)
  AUTHORS   Rondeau,J.M., Tete-Favier,F., Podjarny,A., Reymann,J.M., Barth,P.,
            Biellmann,J.F. and Moras,D.
  TITLE     Novel NADPH-binding domain revealed by the crystal structure of
            aldose reductase
  JOURNAL   Nature 355 (6359), 469-472 (1992)
   PUBMED   1734286
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U46065.1.
FEATURES             Location/Qualifiers
     source          1..316
                     /organism="Sus scrofa"
                     /db_xref="taxon:9823"
     Protein         1..316
                     /product="aldose reductase"
                     /EC_number="1.1.1.21"
                     /function="polyol pathway/detoxification/biogenic amine
                     metabolism"
                     /calculated_mol_wt=35736
     CDS             1..316
                     /gene="ALR2"
                     /gene_synonym="AKR1B1"
                     /coded_by="NM_001001539.1:20..970"
                     /db_xref="GeneID:396816"
ORIGIN      
        1 mashlvlytg akmpilglgt wksppgkvte avkvaidlgy rhidcahvyq nenevglglq
       61 eklqgqvvkr edlfivsklw ctdheknlvk gacqttlrnl kldyldlyli hwptgfkpgk
      121 dpfpldgdgn vvpdesdfve tweameelvd eglvkaigvs nfnhlqveki lnkpglkykp
      181 avnqievhpy ltqeklieyc kskgivvtay splgspdrpw akpedpslle dprikaiaak
      241 ynkttaqvli rfpmqrnliv ipksvtperi aenfqvfdfe lspedmntll synrnwrvca
      301 lmscashkdy pfheey
//