LOCUS NP_000933 216 aa linear PRI 22-OCT-2008
DEFINITION peptidylprolyl isomerase B precursor [Homo sapiens].
ACCESSION NP_000933
VERSION NP_000933.1 GI:4758950
DBSOURCE REFSEQ: accession NM_000942.4
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 216)
AUTHORS Stumpf,T., Zhang,Q., Hirnet,D., Lewandrowski,U., Sickmann,A.,
Wissenbach,U., Dorr,J., Lohr,C., Deitmer,J.W. and Fecher-Trost,C.
TITLE The human TRPV6 channel protein is associated with cyclophilin B in
human placenta
JOURNAL J. Biol. Chem. 283 (26), 18086-18098 (2008)
PUBMED 18445599
REMARK GeneRIF: CypB is a new TRPV6 accessory protein with potential
involvement in TRPV6 channel activation through its peptidyl-prolyl
cis/trans isomerase activity
REFERENCE 2 (residues 1 to 216)
AUTHORS Melchior,A., Denys,A., Deligny,A., Mazurier,J. and Allain,F.
TITLE Cyclophilin B induces integrin-mediated cell adhesion by a
mechanism involving CD98-dependent activation of protein kinase
C-delta and p44/42 mitogen-activated protein kinases
JOURNAL Exp. Cell Res. 314 (3), 616-628 (2008)
PUBMED 18054915
REMARK GeneRIF: Altogether, our results support a model whereby CyPB
induces integrin-mediated adhesion via interaction with a
multimolecular unit formed by the association between CD147, CD98
and beta1 integrins.
REFERENCE 3 (residues 1 to 216)
AUTHORS Vanpouille,C., Deligny,A., Delehedde,M., Denys,A., Melchior,A.,
Lienard,X., Lyon,M., Mazurier,J., Fernig,D.G. and Allain,F.
TITLE The heparin/heparan sulfate sequence that interacts with
cyclophilin B contains a 3-O-sulfated N-unsubstituted glucosamine
residue
JOURNAL J. Biol. Chem. 282 (33), 24416-24429 (2007)
PUBMED 17588944
REMARK GeneRIF: results strongly support the hypothesis that 3-O-sulfation
of GlcNH2 residues could be a key modification that provides
specialized HS structures for CyPB binding to responsive cells
REFERENCE 4 (residues 1 to 216)
AUTHORS Chi,A., Valencia,J.C., Hu,Z.Z., Watabe,H., Yamaguchi,H.,
Mangini,N.J., Huang,H., Canfield,V.A., Cheng,K.C., Yang,F., Abe,R.,
Yamagishi,S., Shabanowitz,J., Hearing,V.J., Wu,C., Appella,E. and
Hunt,D.F.
TITLE Proteomic and bioinformatic characterization of the biogenesis and
function of melanosomes
JOURNAL J. Proteome Res. 5 (11), 3135-3144 (2006)
PUBMED 17081065
REFERENCE 5 (residues 1 to 216)
AUTHORS Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
and Zoghbi,H.Y.
TITLE A protein-protein interaction network for human inherited ataxias
and disorders of Purkinje cell degeneration
JOURNAL Cell 125 (4), 801-814 (2006)
PUBMED 16713569
REFERENCE 6 (residues 1 to 216)
AUTHORS Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
Vandekerckhove,J.
TITLE Microsequences of 145 proteins recorded in the two-dimensional gel
protein database of normal human epidermal keratinocytes
JOURNAL Electrophoresis 13 (12), 960-969 (1992)
PUBMED 1286667
REFERENCE 7 (residues 1 to 216)
AUTHORS Arber,S., Krause,K.H. and Caroni,P.
TITLE s-cyclophilin is retained intracellularly via a unique
COOH-terminal sequence and colocalizes with the calcium storage
protein calreticulin
JOURNAL J. Cell Biol. 116 (1), 113-125 (1992)
PUBMED 1530944
REFERENCE 8 (residues 1 to 216)
AUTHORS Peddada,L.B., McPherson,J.D., Law,R., Wasmuth,J.J., Youderian,P.
and Deans,R.J.
TITLE Somatic cell mapping of the human cyclophilin B gene (PPIB) to
chromosome 15
JOURNAL Cytogenet. Cell Genet. 60 (3-4), 219-221 (1992)
PUBMED 1505219
REFERENCE 9 (residues 1 to 216)
AUTHORS Hasel,K.W., Glass,J.R., Godbout,M. and Sutcliffe,J.G.
TITLE An endoplasmic reticulum-specific cyclophilin
JOURNAL Mol. Cell. Biol. 11 (7), 3484-3491 (1991)
PUBMED 1710767
REFERENCE 10 (residues 1 to 216)
AUTHORS Price,E.R., Zydowsky,L.D., Jin,M.J., Baker,C.H., McKeon,F.D. and
Walsh,C.T.
TITLE Human cyclophilin B: a second cyclophilin gene encodes a
peptidyl-prolyl isomerase with a signal sequence
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 88 (5), 1903-1907 (1991)
PUBMED 2000394
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BQ931949.1, BC008848.2 and
BC001125.2.
Summary: The protein encoded by this gene is a cyclosporine-binding
protein and is mainly located within the endoplasmic reticulum. It
is associated with the secretory pathway and released in biological
fluids. This protein can bind to cells derived from T- and
B-lymphocytes, and may regulate cyclosporine A-mediated
immunosuppression. [provided by RefSeq].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..216
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="15"
/map="15q21-q22"
Protein 1..216
/product="peptidylprolyl isomerase B precursor"
/EC_number="5.2.1.8"
/note="cyclophilin B; peptidyl-prolyl cis-trans isomerase
B; PPIase; cyclophilin-like protein; S-cyclophilin;
rotamase"
sig_peptide 1..25
/calculated_mol_wt=2764
mat_peptide 26..216
/product="peptidylprolyl isomerase B"
/calculated_mol_wt=20996
CDS 1..216
/gene="PPIB"
/gene_synonym="CYPB"
/gene_synonym="SCYLP"
/gene_synonym="CYP-S1"
/gene_synonym="MGC2224"
/gene_synonym="MGC14109"
/coded_by="NM_000942.4:170..820"
/db_xref="CCDS:CCDS10191.1"
/db_xref="GeneID:5479"
/db_xref="HGNC:9255"
/db_xref="HPRD:00458"
/db_xref="MIM:123841"
ORIGIN
1 mlrlsernmk vllaaaliag svfflllpgp saadekkkgp kvtvkvyfdl rigdedvgrv
61 ifglfgktvp ktvdnfvala tgekgfgykn skfhrvikdf miqggdftrg dgtggksiyg
121 erfpdenfkl khygpgwvsm anagkdtngs qffittvkta wldgkhvvfg kvlegmevvr
181 kvestktdsr dkplkdviia dcgkievekp faiake
//