LOCUS NP_000929 1174 aa linear PRI 22-OCT-2008
DEFINITION DNA directed RNA polymerase II polypeptide B [Homo sapiens].
ACCESSION NP_000929
VERSION NP_000929.1 GI:4505941
DBSOURCE REFSEQ: accession NM_000938.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 1174)
AUTHORS Tu,S., Teng,Y.C., Yuan,C., Wu,Y.T., Chan,M.Y., Cheng,A.N.,
Lin,P.H., Juan,L.J. and Tsai,M.D.
TITLE The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC
motif
JOURNAL Nat. Struct. Mol. Biol. 15 (4), 419-421 (2008)
PUBMED 18270511
REMARK GeneRIF: ARID is required for RBP2 demethylase activity in cells
and that DNA recognition is essential to regulate transcription
REFERENCE 2 (residues 1 to 1174)
AUTHORS O'Reilly,D. and Greaves,D.R.
TITLE Cell-type-specific expression of the human CD68 gene is associated
with changes in Pol II phosphorylation and short-range
intrachromosomal gene looping
JOURNAL Genomics 90 (3), 407-415 (2007)
PUBMED 17583472
REMARK GeneRIF: human CD68 gene expression is associated with changes in
Pol II phosphorylation and short-range intrachromosomal gene
looping
REFERENCE 3 (residues 1 to 1174)
AUTHORS Michiels,S., Danoy,P., Dessen,P., Bera,A., Boulet,T., Bouchardy,C.,
Lathrop,M., Sarasin,A. and Benhamou,S.
TITLE Polymorphism discovery in 62 DNA repair genes and haplotype
associations with risks for lung and head and neck cancers
JOURNAL Carcinogenesis 28 (8), 1731-1739 (2007)
PUBMED 17494052
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 4 (residues 1 to 1174)
AUTHORS Yamaguchi,Y., Mura,T., Chanarat,S., Okamoto,S. and Handa,H.
TITLE Hepatitis delta antigen binds to the clamp of RNA polymerase II and
affects transcriptional fidelity
JOURNAL Genes Cells 12 (7), 863-875 (2007)
PUBMED 17584298
REMARK GeneRIF: By reducing transcriptional fidelity in terms of not only
discrimination of incoming nucleotides but also recognition of
templates, HDAg may facilitate the unusual RNA-dependent RNA
synthesis by Pol II.
REFERENCE 5 (residues 1 to 1174)
AUTHORS Johnson,S.S., Zhang,C., Fromm,J., Willis,I.M. and Johnson,D.L.
TITLE Mammalian Maf1 is a negative regulator of transcription by all
three nuclear RNA polymerases
JOURNAL Mol. Cell 26 (3), 367-379 (2007)
PUBMED 17499043
REMARK GeneRIF: the human Maf1 protein negatively regulates transcription
by all three nuclear Pols, Pol I, Pol II and Pol III
REFERENCE 6 (residues 1 to 1174)
AUTHORS Acker,J., Wintzerith,M., Vigneron,M. and Kedinger,C.
TITLE Primary structure of the second largest subunit of human RNA
polymerase II (or B)
JOURNAL J. Mol. Biol. 226 (4), 1295-1299 (1992)
PUBMED 1518060
REFERENCE 7 (residues 1 to 1174)
AUTHORS Kato,H., Sumimoto,H., Pognonec,P., Chen,C.H., Rosen,C.A. and
Roeder,R.G.
TITLE HIV-1 Tat acts as a processivity factor in vitro in conjunction
with cellular elongation factors
JOURNAL Genes Dev. 6 (4), 655-666 (1992)
PUBMED 1559613
REFERENCE 8 (residues 1 to 1174)
AUTHORS Jacob,G.A., Luse,S.W. and Luse,D.S.
TITLE Abortive initiation is increased only for the weakest members of a
set of down mutants of the adenovirus 2 major late promoter
JOURNAL J. Biol. Chem. 266 (33), 22537-22544 (1991)
PUBMED 1939271
REFERENCE 9 (residues 1 to 1174)
AUTHORS Southgate,C., Zapp,M.L. and Green,M.R.
TITLE Activation of transcription by HIV-1 Tat protein tethered to
nascent RNA through another protein
JOURNAL Nature 345 (6276), 640-642 (1990)
PUBMED 2190099
REFERENCE 10 (residues 1 to 1174)
AUTHORS Zheng,X.M., Black,D., Chambon,P. and Egly,J.M.
TITLE Sequencing and expression of complementary DNA for the general
transcription factor BTF3
JOURNAL Nature 344 (6266), 556-559 (1990)
PUBMED 2320128
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from X63563.1.
Summary: This gene encodes the second largest subunit of RNA
polymerase II, the polymerase responsible for synthesizing
messenger RNA in eukaryotes. This subunit, in combination with at
least two other polymerase subunits, forms a structure within the
polymerase that maintains contact in the active site of the enzyme
between the DNA template and the newly synthesized RNA. [provided
by RefSeq].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..1174
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="4"
/map="4q12"
Protein 1..1174
/product="DNA directed RNA polymerase II polypeptide B"
/EC_number="2.7.7.6"
/note="polymerase (RNA) II (DNA directed) polypeptide B
(140kD); DNA directed RNA polymerase II 140 kDa
polypeptide, RNA polymerase II subunit 2, RNA polymerase
II second largest subunit"
/calculated_mol_wt=133766
CDS 1..1174
/gene="POLR2B"
/gene_synonym="RPB2"
/gene_synonym="POL2RB"
/gene_synonym="hsRPB2"
/gene_synonym="hRPB140"
/coded_by="NM_000938.1:44..3568"
/db_xref="CCDS:CCDS3511.1"
/db_xref="GeneID:5431"
/db_xref="HGNC:9188"
/db_xref="HPRD:15943"
/db_xref="MIM:180661"
ORIGIN
1 mydadedmqy dedddeitpd lwqeacwivi ssyfdekglv rqqldsfdef iqmsvqrive
61 dappidlqae aqhasgevee ppryllkfeq iylskpthwe rdgapspmmp nearlrnlty
121 saplyvditk tvikegeeql qtqhqktfig kipimlrsty cllngltdrd lcelnecpld
181 pggyfiings ekvliaqekm atntvyvfak kdskyaytge crsclenssr ptstiwvsml
241 arggqgakks aigqrivatl pyikqevpii ivfralgfvs drdilehiiy dfedpemmem
301 vkpsldeafv iqeqnvalnf igsrgakpgv tkekrikyak evlqkemlph vgvsdfcetk
361 kayflgymvh rlllaalgrr elddrdhygn krldlagpll aflfrgmfkn llkevriyaq
421 kfidrgkdfn lelaiktrii sdglkyslat gnwgdqkkah qaragvsqvl nrltfastls
481 hlrrlnspig rdgklakprq lhntlwgmvc paetpeghav glvknlalma yisvgsqpsp
541 ilefleewsm enleeispaa iadatkifvn gcwvgihkdp eqlmntlrkl rrqmdiivse
601 vsmirdirer eiriytdagr icrpllivek qklllkkrhi dqlkereynn yswqdlvasg
661 vveyidtlee etvmlamtpd dlqekevayc stythceihp smilgvcasi ipfpdhnqsp
721 rntyqsamgk qamgvyitnf hvrmdtlahv lyypqkplvt trsmeylrfr elpaginsiv
781 aiasytgynq edsvimnrsa vdrgffrsvf yrsykeqesk kgfdqeevfe kptretcqgm
841 rhaiydkldd dgliapgvrv sgddviigkt vtlpenedel estnrrytkr dcstflrtse
901 tgivdqvmvt lnqegykfck irvrsvripq igdkfasrhg qkgtcgiqyr qedmpftceg
961 itpdiiinph aipsrmtigh lieclqgkvs ankgeigdat pfndavnvqk isnllsdygy
1021 hlrgnevlyn gftgrkitsq ifigptyyqr lkhmvddkih srargpiqil nrqpmegrsr
1081 dgglrfgeme rdcqiahgaa qflrerlfea sdpyqvhvcn lcgimaiant rthtyecrgc
1141 rnktqislvr mpyackllfq elmsmsiapr mmsv
//