LOCUS NP_000925 491 aa linear PRI 21-SEP-2008
DEFINITION alpha-2-plasmin inhibitor [Homo sapiens].
ACCESSION NP_000925
VERSION NP_000925.2 GI:115583663
DBSOURCE REFSEQ: accession NM_000934.3
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 491)
AUTHORS Barbe,L., Lundberg,E., Oksvold,P., Stenius,A., Lewin,E.,
Bjorling,E., Asplund,A., Ponten,F., Brismar,H., Uhlen,M. and
Andersson-Svahn,H.
TITLE Toward a confocal subcellular atlas of the human proteome
JOURNAL Mol. Cell Proteomics 7 (3), 499-508 (2008)
PUBMED 18029348
REFERENCE 2 (residues 1 to 491)
AUTHORS Marti-Fabregas,J., Borrell,M., Cocho,D., Martinez-Ramirez,S.,
Martinez-Corral,M., Fontcuberta,J. and Marti-Vilalta,J.L.
TITLE Change in hemostatic markers after recombinant tissue-type
plasminogen activator is not associated with the chance of
recanalization
JOURNAL Stroke 39 (1), 234-236 (2008)
PUBMED 18048863
REMARK GeneRIF: Thrombin activatable fibrinolysis inhibitor and
alpha(2)-antiplasmin are not markers for recanalization in patients
with ischemic stroke treated with recombinant tissue-type
plasminogen activator.
REFERENCE 3 (residues 1 to 491)
AUTHORS Maino,A., Garagiola,I., Artoni,A., Al-Humood,S. and Peyvandi,F.
TITLE A novel mutation of alpha2-plasmin inhibitor gene causes an
inherited deficiency and a bleeding tendency
JOURNAL Haemophilia 14 (1), 166 (2008)
PUBMED 17961166
REMARK GeneRIF: Sequencing analysis revealed the presence of two alpha2-PI
gene variations, both in the second half of exon 10: a frameshift
mutation and a G to A transition at nucleotide 11337 in codon 407.
REFERENCE 4 (residues 1 to 491)
AUTHORS Nielsen,V.G.
TITLE Hydroxyethyl starch enhances fibrinolysis in human plasma by
diminishing alpha2-antiplasmin-plasmin interactions
JOURNAL Blood Coagul. Fibrinolysis 18 (7), 647-656 (2007)
PUBMED 17890952
REMARK GeneRIF: Hydroxyethyl starch (HES) dilution enhances fibrinolysis
by diminishing alpha2-antiplasmin-plasmin interactions.
REFERENCE 5 (residues 1 to 491)
AUTHORS Sazonova,I.Y., Thomas,B.M., Gladysheva,I.P., Houng,A.K. and
Reed,G.L.
TITLE Fibrinolysis is amplified by converting alpha-antiplasmin from a
plasmin inhibitor to a substrate
JOURNAL J. Thromb. Haemost. 5 (10), 2087-2094 (2007)
PUBMED 17883703
REMARK GeneRIF: Fibrinolysis is amplified by converting alpha-antiplasmin
from a plasmin inhibitor to a substrate
REFERENCE 6 (residues 1 to 491)
AUTHORS Christensen,S. and Sottrup-Jensen,L.
TITLE Bovine alpha 2-antiplasmin. N-terminal and reactive site sequence
JOURNAL FEBS Lett. 312 (1), 100-104 (1992)
PUBMED 1385210
REFERENCE 7 (residues 1 to 491)
AUTHORS Welch,S.K. and Francke,U.
TITLE Assignment of the human alpha 2-plasmin inhibitor gene (PLI) to
chromosome 17, region pter-p12, by PCR analysis of somatic cell
hybrids
JOURNAL Genomics 13 (1), 213-214 (1992)
PUBMED 1577485
REFERENCE 8 (residues 1 to 491)
AUTHORS Wiman,B. and Collen,D.
TITLE On the mechanism of the reaction between human alpha 2-antiplasmin
and plasmin
JOURNAL J. Biol. Chem. 254 (18), 9291-9297 (1979)
PUBMED 158022
REFERENCE 9 (residues 1 to 491)
AUTHORS Wiman,B. and Collen,D.
TITLE Purification and characterization of human antiplasmin, the
fast-acting plasmin inhibitor in plasma
JOURNAL Eur. J. Biochem. 78 (1), 19-26 (1977)
PUBMED 21075
REFERENCE 10 (residues 1 to 491)
AUTHORS Moroi,M. and Aoki,N.
TITLE Isolation and characterization of alpha2-plasmin inhibitor from
human plasma. A novel proteinase inhibitor which inhibits
activator-induced clot lysis
JOURNAL J. Biol. Chem. 251 (19), 5956-5965 (1976)
PUBMED 134998
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BX107460.1, BC031592.1 and J02654.1.
On Oct 6, 2006 this sequence version replaced gi:11386143.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..491
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="17"
/map="17p13"
Protein 1..491
/product="alpha-2-plasmin inhibitor"
/note="serine (or cysteine) proteinase inhibitor, clade F
(alpha-2 antiplasmin, pigment epithelium derived factor),
member 2; alpha-2-antiplasmin"
/calculated_mol_wt=54435
CDS 1..491
/gene="SERPINF2"
/gene_synonym="AAP"
/gene_synonym="API"
/gene_synonym="PLI"
/gene_synonym="A2AP"
/gene_synonym="ALPHA-2-PI"
/coded_by="NM_000934.3:78..1553"
/db_xref="CCDS:CCDS11011.1"
/db_xref="GeneID:5345"
/db_xref="HGNC:9075"
/db_xref="HPRD:02029"
/db_xref="MIM:262850"
ORIGIN
1 mallwgllvl swsclqgpcs vfspvsamep lgrqltsgpn qeqvspltll klgnqepggq
61 talksppgvc srdptpeqth rlarammaft adlfslvaqt stcpnlilsp lsvalalshl
121 algaqnhtlq rlqqvlhags gpclphllsr lcqdlgpgaf rlaarmylqk gfpikedfle
181 qseqlfgakp vsltgkqedd laninqwvke ategkiqefl sglpedtvll llnaihfqgf
241 wrnkfdpslt qrdsfhldeq ftvpvemmqa rtyplrwfll eqpeiqvahf pfknnmsfvv
301 lvpthfewnv sqvlanlswd tlhpplvwer ptkvrlpkly lkhqmdlvat lsqlglqelf
361 qapdlrgise qslvvsgvqh qstlelsevg veaaaatsia msrmslssfs vnrpflffif
421 edttglplfv gsvrnpnpsa prelkeqqds pgnkdflqsl kgfprgdklf gpdlklvppm
481 eedypqfgsp k
//